Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

Fong, Sophia Yui Kau; Wong, Yin Cheong; Xie, Chen; Zuo, Zhong

doi:10.1016/j.jep.2015.04.036

Cited by 33 publications

(11 citation statements)

References 36 publications

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“…Oral administration of SR water extract for 10 days significantly inhibited tumor size in mouse xenograft model 39 . After oral administration of SR for 5 days in rat model, the level of PGE2 in LPS-stimulated macrophages was reduced robustly, and the pharmacodynamic interaction was proposed to be via the Cox–2 pathway 40 . The major metabolites were reported to be baicalin and baicalein by utilizing HPLC coupled with electrochemical detector 41 .…”

Section: Discussionmentioning

confidence: 99%

Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages

Gong

Wang

Kong

et al. 2018

Sci Rep

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Scutellariae Radix (SR), also named Huangqin in China, is the dried root of Scutellaria baicalensis Georgi. Historically, the usage of SR was targeted to against inflammation. In fact, chronic inflammation has a close relationship with hypoxia and abnormal angiogenesis in tumor cells. Hence, we would like to probe the water extract of SR in suppressing the inflammation-induced angiogenesis. Prior to determine the pharmaceutical values of SR, the first step is to analysis the chemical compositions of SR according to China Pharmacopeia (2015). From the results, the amount of baicalin was 12.6% by weight. Furthermore, the anti-angiogenic properties of SR water extract were evaluated in lipopolysaccharide (LPS) pre-treated cultured macrophage RAW 264.7 cells by detecting the inflammatory markers, i.e. Cox-2, cytokine and iNOS, as well as the translocation activity of NFκB and angiogenic biomarker, i.e. VEGF. This herbal extract was capable of declining both inflammatory and angiogenic hallmarks in a concentration-dependent manner. Moreover, the SR-derived flavonoids, i.e. baicalin, baicalein, wogonin and wogonoside, were shown to be active chemicals in the anti-inflammatory-induced angiogenesis. Therefore, the inflammation-induced angiogenesis is believed to be suppressed by SR water extract, or its major ingredients. These results shed light in the benefiting role of SR in the inflammation-induced angiogenesis in vitro.

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Section: Discussionmentioning

confidence: 99%

Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages

Gong

Wang

Kong

et al. 2018

Sci Rep

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“…Presently, combination therapies of TM and western medicine are increasingly applied in clinical practice. Over the past decade, a number of significant TM-drug interactions have been reported [ 12 , 13 , 23 ]. Therefore, numerous studies have focused on understanding underlying mechanisms of action involved.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Lou

Zhang

et al. 2018

Exp. Anim.

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Clinical studies that focused on treating schizophrenia showed that Calculus Bovis Sativus (CBS), a substitute of Calculus Bovis, when used in combination with haloperidol could significantly lower the dosage of haloperidol compared with treatment with haloperidol alone, whereas efficacy was maintained. The aim of this study was to investigate the synergetic anti-schizophrenia effects in rats using CBS in combination with haloperidol. An open field test was conducted to verify the pharmacodynamic effects of a combination treatment of CBS and haloperidol on MK-801-induced schizophrenic rats. Rat plasma concentrations of intragastric haloperidol and intravenous haloperidol were determined after oral administration of a single dose or 1-week of pretreatment with CBS (50 mg/kg). The pharmacodynamic data showed a significant decrease in locomotor activity and an increase in the percentage of the central distance when haloperidol was concomitantly administered with CBS compared with haloperidol administration alone. The AUC0-∞ and Cmax of haloperidol in the orally coadministered groups were significantly higher compared with the oral treatment with haloperidol alone. In conclusion, oral coadministration of CBS with haloperidol resulted in a synergistic effect in rats. The enhanced oral bioavailability of haloperidol when combined with CBS might be attributed to the interaction between them.

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“…We found that the experimental value of the ED 50 (Zexp) of each combination tested was significantly lower than the ED 50 theoretical (Zadd) value predicted for an additive relationship (Figure ). In this sense, it is worth mentioning that the use of pharmacological combination for the prevention and management of NSAID‐related gastrointestinal toxicity is a new approach that would reduce the doses of the administered compounds (Arroyo‐Lira, Rodríguez‐Ramos, & Chávez‐Piña, ; Fong, Wong, Xie, & Zuo, ; Ortiz, ). For example, some studies tested the gastroprotective effect of the coadministration N‐acetylcysteine (NAC) and genistein (GEN) on an experimental model of indomethacin‐induced gastric injury, in which a significantly better gastroprotective effect was obtained (Hegab, Abd‐Ellatif, & Sadek, ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic interaction of 3α‐hydroxymasticadienonic acid and diligustilide against indomethacin‐induced gastric damage in rats

Pineda-Peña

Meza-Pérez

Chávez-Piña

et al. 2019

Drug Development Research

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The aims of the study were to evaluate the pharmacodynamic interaction between 3α-hydroxymasticadienonic acid and diligustilide (DLG), isolated from the plants Amphiptherygium adstringens and Ligusticum porteri, respectively, using the indomethacininduced gastric injury model, as well as their individual gastroprotective efficacy in this model. Male Wistar rats were orally administered with 3α-hydroxymasticadienonic acid, DLG or the mixture of 3α-hydroxymasticadienonic acid-DLG (at a fixed-ratio combination of 1:1, 1:3, and 3:1). Thirty minutes later, the gastric damage was induced by a single oral dose of indomethacin (30 mg/kg). Three hours later, the gastric injury (mm 2 ) was determined. 3α-hydroxymasticadienonic acid and DLG as individual compounds showed a gastroprotective effect against indomethacin-induced gastric damage (p < .05).The effective dose (ED 50 ) values for each compound were 6.96 ± 1.25 mg/kg for 3α-hydroxymasticadienonic acid and 2.63 ± 0.37 mg/kg for DLG. The isobolographic analysis performed showed that the combination exhibited super-additive interaction as the experimental ED 50 values (Zexp) were lower than theoretical additive dose values (Zadd; p < .05). Our results identify the super-additive (synergist) interaction between 3α-hydroxymasticadienonic acid and DLG and the gastric safety of both compounds in the indomethacin-induced gastric injury model, suggesting their potential in the future as a strategy to decrease the gastric damage associated to the chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs). K E Y W O R D S3α-hydroxymasticadienonic acid, diligustilide, gastric injury, isobolographic analysis, NSAIDs

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Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

Cited by 33 publications

References 36 publications

Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages

Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Pharmacodynamic interaction of 3α‐hydroxymasticadienonic acid and diligustilide against indomethacin‐induced gastric damage in rats

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