Herbal Approach in Management of Nephrotic Syndrome

Abstract

Nephrotic syndrome (NS) is an important chronic renal disease prevalent among pediatric population. Nephrotic syndrome has emerged as immunological disorder. Researches on pathogenesis have shown T lymphocyte dysregulation and vascular permeability factors that might contribute the alteration in podocyte function and permselectivity resulting in NS. Prognosis of treatment depends upon steroid responsiveness. Most of them are sensitive initially but later on may relapse or become steroid dependent or resistant to it. Drugs like levamisole, cyclophosphamide, cyclosporine, long term alternate day corticosteroids etc. have been used in combination with various protocols to treat steroid dependent or steroid resistant NS with variable results outcome and more side effects. Hence an alternative therapy is needed. Ayurvedic polyherbal formulation with properties of immunomodulator, nephroprotective and antioxidant properties can prove more beneficial in treating steroid dependent or resistant cases of NS, as add on therapy with modern therapeutic drugs for better results.

Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

“…The (d–d) electronic transitions and magnetic moment value demonstrate a high spin octahedral geometry for Co(II) complex. [ 62,66 ]…”

“…provides another evidence for this proposed geometrical structure. [ 66–68 ] The observed low magnetic moment value of this complex is due to the effect of Cu–Cu interaction, ligand field, or considerable electron delocalization. [ 69 ]…”

“…The (d-d) electronic transitions and magnetic moment value demonstrate a high spin octahedral geometry for Co(II) complex. [62,66] The electronic spectrum of [Ni(HL)Cl 2 (EtOH) 2 ]. 0.75EtOH complex (2) displays two remarkable electronic transition bands at 678 and 523 nm (Table 4), ascribed to 3 A 2g (F) !…”

“…provides another evidence for this proposed geometrical structure. [66][67][68] The observed low magnetic moment value of this complex is due to the effect of Cu-Cu interaction, ligand field, or considerable electron delocalization. [69] The electronic spectrum of Cu(II) complexes (4-6) exhibits two transition bands within ranges 673-674 and 557-575 nm, attributed to 2 B 1g !…”