Herbal bioactive–based vaginal and rectal drug delivery systems

Deshkar, Sanjeevani Shekhar; Mahore, Jayashri G.

doi:10.1016/b978-0-12-824385-5.00017-0

Cited by 3 publications

(3 citation statements)

References 297 publications

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“…Medicinal plants are in a continuous process of exploration, resulting in the unearthing of novel plant-based pharmaceuticals to understand the molecular mechanisms of conventional medication and its active ingredients, which may help the renovation of plant-derived medications and detection of novel phyto-agents [63]. Phytomedicine may include several issues such as using medicinal plants as wound healing agents [64,65], natural anti-microbials from plants [66], herbal therapy or remedies [67], herbal cosmeticology [68], phytopharmaceuticals [69,70], phyto-pharmacology [71] using the herbal bioactivities in drug delivery systems like the ocular [72], pulmonary [73], transdermal [74], and vaginal and rectal drug delivery systems [75]. Therefore, it is very important to know exactly what we eat to stay healthy for a long time as conveyed by the term "nutraceuticals" [76].…”

Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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The Kingdom of Plantae is considered the main source of human food, and includes several edible and medicinal plants, whereas mushrooms belong to the Kingdom of fungi. There are a lot of similar characteristics between mushrooms and higher plants, but there are also many differences among them, especially from the human health point of view. The absences of both chlorophyll content and the ability to form their own food are the main differences between mushrooms and higher plants. The main similar attributes found in both mushrooms and higher plants are represented in their nutritional and medicinal activities. The findings of this review have a number of practical implications. A lot of applications in different fields could be found also for both mushrooms and higher plants, especially in the bioenergy, biorefinery, soil restoration, and pharmaceutical fields, but this study is the first report on a comparative photographic review between them. An implication of the most important findings in this review is that both mushrooms and plants should be taken into account when integrated food and energy are needed. These findings will be of broad use to the scientific and biomedical communities. Further investigation and experimentation into the integration and production of food crops and mushrooms are strongly recommended under different environmental conditions, particularly climate change.

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Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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“…They do not expulse so rapidly from the vagina by self-cleaning. Despite all the benefits of vaginal application, the changes during menstruation and the post-menopausal cycle due to hormonal fluctuation have to be taken into account [15]. In women after menopause, the reduction in vaginal epithelial thickness may significantly modify the initial rate of drug absorption.…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the Composition

Bartoníková,

Špaglová,

Papadakos

et al. 2024

Sci. Pharm.

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(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets containing metronidazole (167 mg/g). (2) Methods: The quality of the tablets prepared by direct compression was evaluated by pharmacopoeia tests (uniformity of mass, resistance to crushing, friability). Mucoadhesion of the tablets was characterized by swelling capacity and mucoadhesive strength, i.e., the force required to detach the tablet from the rabbit mucosa. In vitro drug release was performed by a modified dissolution method in paddle apparatus containing the simulated vaginal fluid (pH 4.5). Scanning electron microscopy observed morphological changes on the swollen tablets’ surface. (3) Results: Pharmacopoeia tests have shown that all prepared tablets met the requirements on quality. The highest mucoadhesive strength was noted in tablets containing guar and xanthan gum. The highest swelling capacity was possessed by tablets containing carrageenan. (4) Conclusions: Summarizing all tests’ results, sodium alginate can be considered the most suitable natural polymer in tablet formulation. The combination of polymers providing higher mucoadhesiveness and at the same time a prolonged release, e.g., xanthan or guar, together with sodium alginate, could also be of interest.

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“…It is a crucial component of the conventional medical system and is frequently used in conjunction with conventional therapy to treat stubborn ailments including cancer. 17,18,19 Extracts from A. muricata are among a myriad of botanical products which have promising medicinal values. Numerous health benefits 20 have been attributed to A. muricata, most of which has been linked to its antioxidant potential.…”

Section: Introductionmentioning

confidence: 99%

Annona muricata Leaf Extract Modulates Chloramphenicol-Induced Lymphoma in Female Wistar Rats

2023

TJNPR

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Chloramphenicol, an antibiotic used to treat bacterial infections, is also implicated in several conditions, including aplastic anaemia that progresses to leukaemia. The modulatory potential of leaf extract of Annona muricata on chloramphenicol-induced lymphoma (CIL) in female Wistar rats was investigated. Forty-eight adult female rats with an average weight of 186 g were randomized into 6 groups of 8 rats each. Rats in Group 1 served as the positive control. Each rat in Groups 2-6 was orally administered with 250 mg/kg bodyweight chloramphenicol once daily for 28 days. The rats were given access to basal diet and water. After 28 days, blood-film analyses were carried out from each of the groups. The presence of blast and lymphoproliferative cells in Groups 2-6 confirmed CIL. Groups 1 and 2 rats received distilled water, while Groups 3-6 received 500, 1000, 1500, and 2000 mg/kg, respectively, of A. muricata for another 28 days. The animals were anesthetized, blood was collected from the retro-orbital venous plexus for determination of haematological indices; oxidative stress markers; lactate dehydrogenase, superoxide dismutase, catalase, glutathione, malondialdehyde, cardiac markers; Troponin-1, myoglobin, cancer indices; C-reactive protein, carcinoembryonic antigen, Alpha-fetoprotein. There was significant (p<0.05) amelioration of impaired haematological indices in the treated groups when compared to Group 2. Troponin-I and myoglobin were significantly (p<0.05) lowered in the treated groups when compared to Group 2. Oxidative stress markers and cancer indices were increased in Group 2, but significantly (p<0.05) ameliorated in Groups 3-6. Therefore, A. muricata has the potential to modulate adverse effects of CIL.

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Herbal bioactive–based vaginal and rectal drug delivery systems

Cited by 3 publications

References 297 publications

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the Composition

Annona muricata Leaf Extract Modulates Chloramphenicol-Induced Lymphoma in Female Wistar Rats

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