Herbal bioactive-incorporated scaffolds for wound healing applications

Sharma, Ameya; Puri, Vivek; Bakshi, Inderbir Singh; Kumar, Pradeep

doi:10.1016/b978-0-12-824385-5.00018-2

Cited by 2 publications

(3 citation statements)

References 47 publications

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“…Several antioxidants effectively control the oxidative stress in the wound and aid wound healing. A detailed overview of the antioxidant phytochemicals in wound healing applications has been explicitly discussed elsewhere. − This work examined the innovative antioxidant techniques used for quick wound healing in recent years. Figure depicts several unique antioxidant treatment methods for fast wound healing.…”

Section: Emerging Antioxidant Novel Therapeutics For Combating the Ox...mentioning

confidence: 99%

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

et al. 2022

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Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive ROS levels in the wound site show deleterious effects on wound healing by extending the inflammation phase. Understanding the ROS-mediated molecular and biomolecular mechanisms and their effect on cellular homeostasis and inflammation thus substantially improves the possibility of exogenously augmenting and manipulating wound healing with the emerging antioxidant therapeutics. This review comprehensively delves into the relationship between ROS and critical phases of wound healing and the processes underpinning antioxidant therapies. The manuscript also discusses cutting-edge antioxidant therapeutics that act via ROS scavenging to enhance chronic wound healing.

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Section: Emerging Antioxidant Novel Therapeutics For Combating the Ox...mentioning

confidence: 99%

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

et al. 2022

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“…Healing in chronic wounds could be accelerated through strategic modulation of the microenvironment of the injury 6,13 . Improving wound healing through antioxidant therapy has been recognized through oral supplements and topical products, including modified hydrogels 14–19 . These materials, combining antioxidant species of natural and synthetic origin, have demonstrated the potential to neutralize oxidant entities, maintain the natural physiological balance of ROS during healing, and enhance wound healing responses, albeit almost exclusively outside of a clinical setting 14–16,20–23 .…”

Section: Introductionmentioning

confidence: 99%

“…6,13 Improving wound healing through antioxidant therapy has been recognized through oral supplements and topical products, including modified hydrogels. [14][15][16][17][18][19] These materials, combining antioxidant species of natural and synthetic origin, have demonstrated the potential to neutralize oxidant entities, maintain the natural physiological balance of ROS during healing, and enhance wound healing responses, albeit almost exclusively outside of a clinical setting. [14][15][16][20][21][22][23] Yet, novel formulations to deliver bioprotective antioxidants with cell-based therapies represent untapped therapeutic potential.…”

mentioning

confidence: 99%

Characterization and biological evaluation of a novel flavonoid‐collagen antioxidant hydrogel with cytoprotective properties

Nalband,

Sarker,

Khan

et al. 2023

J Biomed Mater Res

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Reactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub‐optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three‐dimensional architecture. Yet, they lack the inherent antioxidant activity that could help mitigate excess ROS at a wound site. This work formulates and evaluates the in vitro biocompatibility and antioxidant capabilities of collagen‐fibroblast hydrogels combined with the polyphenolic antioxidant luteolin. Collagen solutions mixed with luteolin readily assembled into robust hydrogels with increasing gel strength due to increasing concentrations of luteolin. SEM images confirmed a mean pore size of 2.2 μm and a drastically different macromolecular ultrastructure with extensive fine crosslinking relative to collagen. Adequate cell viability and metabolic activity of dermal fibroblasts cultured within the gels were measured across all formulations, resulting in higher antioxidant activity and more than double the protection to cells from oxidative damage than traditional collagen hydrogels. Given these results, luteolin‐collagen hydrogels demonstrate the potential for superior wound‐healing properties when compared to collagen alone.

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Herbal bioactive-incorporated scaffolds for wound healing applications

Cited by 2 publications

References 47 publications

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

Characterization and biological evaluation of a novel flavonoid‐collagen antioxidant hydrogel with cytoprotective properties

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