Herbal dewormer fails to control gastrointestinal nematodes in goats

Burke, J.M.; Wells, Amy; Casey, Patrick J.; Kaplan, Ray M.

doi:10.1016/j.vetpar.2008.10.080

Cited by 33 publications

(21 citation statements)

References 12 publications

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“…3). Similarly to our present results, Burke et al (2009a) reported a lack of signifi cant anti-helminthic effects of a herbal mixture containing Artemisia absinthium, Allium sativum, Thymus vulgaris, fennel Foeniculum vulgare, black walnut Juglans nigra, pumpkin Cucurbita pepo, hyssop Hyssopus offi cinalis, and sweetleaf Stevia rebaudiana in goats. Furthermore, in the trial conducted by Luginbuhl et al (2006), another commercially available herbal de-wormer was ineffective in reducing EPG counts in goats, and in the study by Bouilhol et al (2001) there were no apparent anti-parasitic effects of fi ve different herbal preparations on gastrointestinal helminths in grazing sheep.…”

Section: Resultssupporting

confidence: 88%

“…A broad range of ethnoveterinary therapeutic products, most of them utilizing various medicinal plants with anti-parasitic effects, are currently being evaluated (Akhtar et al, 2000;Waller et al, 2001;Githiori et al, 2006;Athanasiadou et al, 2007). However, the effectiveness of herbal formulations marketed for parasite control in small ruminants under fi eld conditions has been scarcely documented (Bouilhol et al, 2001;Luginbuhl et al, 2006;Burke et al, 2009a). Hence, the main objective of the present study was to determine the utility of commercially available mineral licks containing the herbal extracts with anti-parasitic properties on the level and dynamics of gastrointestinal helminth infections in previously de-wormed sheep throughout the grazing season.…”

Section: Introductionmentioning

confidence: 99%

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Assessing the usefulness of mineral licks containing herbal extracts with anti-parasitic properties for the control of gastrointestinal helminths in grazing sheep – a field trial

et al. 2016

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SummaryOne of the alternative methods of parasite control, of particular importance in sustainable farming, is the use of medicinal plants. The specifi c aim of the present fi eld trial was to assess the anti-parasitic effects of herbal extracts contained in a commercially available lick formulation for sheep. At the outset of this study conducted during the grazing season, all animals were de-wormed and then randomly assigned to one of the two separately kept groups (treatment and control), each consisting of 25 animals (11 ewes and 14 lambs). The treatment group received mineral licks containing the extracts of the plants with anti-parasitic properties, while control animals received standard mineral licks ad libitum. Rectal fecal samples were collected monthly from all animals for the McMaster analyses. There were no signifi cant differences in the prevalence and intensity of helminth infections between the treatment and control groups. Thus, we were not able to ascertain the effi cacy of the commercial herbal de-wormer tested for the control of gastrointestinal helminths in grazing ewes and their lambs.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Assessing the usefulness of mineral licks containing herbal extracts with anti-parasitic properties for the control of gastrointestinal helminths in grazing sheep – a field trial

et al. 2016

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“…For example, Githiori et al (2003) tested seven local plants used to treat anthelmintic infections in Kenya and found that only one (Ananas comosus) had weak in vitro activity. In addition, a recent study found that when goats and kids were fed a commercial herbal feed supplement containing a mix of several herbs traditionally used as vermifuges (Artemisia absinthium (wormwood), Allium sativum (garlic), Juglans nigra (black walnut), Cucurbita pepo (field pumpkin), Artemisia vulgaris (mugwort), Foeniculum vulgare (fennel), Hyssopus officinalis (hyssop), and Thymus vulgaris (thyme)) at a dose of 19 g for three days, the supplement failed to control intestinal parasites (Burke et al 2009). This suggests that other factors, including amount of plant consumed (dose and length of administration), the effects of manufacturing and packaging, and even metabolite stability may influence the bioactivity of such supplements.…”

Section: Perspec Vesmentioning

confidence: 99%

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

French

2018

EBL

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Anthelmintic resistance in livestock is increasing globally. Livestock intestinal parasites now develop resistance to synthetic anthelmintics within 2–10 years, collectively costing billions of dollars annually in lost revenue around the world. Over-reliance on commercial drugs and dips and changes in livestock management practices are key drivers of this trend. To date, current research has focused on identifying new anthelmintics from bacterial and fungal sources or even synthesizing new drugs that target parasite metabolism or reproduction. Plant-derived anthelmintics are a promising alternative, yet to date major research funders and scientists have overlooked this option. Until the mid-20th century, rural communities relied on plant-based methods of controlling livestock parasites. These methods include feeding livestock specific medicinal plants and trees, grazing livestock on herbal leys, and changing where livestock grazed based on ecological factors (e.g., flooding) that increased parasite burdens. Many historic texts and ethnological accounts record the ethnobotanical knowledge of rural communities and the plants they used to control livestock intestinal parasites. Some traditions persist today yet the farmers, graziers, and shepherds who hold this knowledge are rapidly disappearing and with them perhaps a potential long-term solution to anthelmintic resistance. This short perspective piece will cover recent research using ethnobotanical data as a means to identifying potential new anthelmintics; the morphological, physiological, and metabolic effect of plant secondary metabolites on parasites; and an overview of “best practices” which can reduce bias in assessments of plant bioactivity and increase reproducibility of test results. This will hopefully bring recent advances in ethnobiology, chemistry, and ecology to new audiences, and, potentially, spark new interest in using medicinal plants to improve livestock health.

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“…Crude extracts of both Artemisia vulgaris and A. absinthium significantly decreased infectivity of Trichinella spiralis in infected mice (Caner et al 2008), and sheep infected with Haemonchus and fed A. absinthium as 20% of their diet during the infection period had a significant reduction in fecal egg counts (FEC) and number of adults when compared to diets containing sainfoin and sulla (Valderrábano et al 2010). However, a commercial dewormer containing both A. vulgaris and A. absinthium, among other plants, and used at 19.0 g/animal/day for 3 days failed to control gastrointestinal nematodes in goats (Burke et al 2009). A recent historic account reports the use of medicinal plants, including A. absinthium, by the Etruscans to control F. hepatica during the first millenium B.C., and as a tincture in the West Indies to prevent worm infections in horses, cattle, and sheep (Harrison and Turfa 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

Ferreira¹,

Peaden²,

Keiser

2011

Parasitol Res

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Trematode infections negatively affect human and livestock health, and threaten global food safety. The only approved human anthelmintics for trematodiasis are triclabendazole and praziquantel with no alternative drugs in sight. We tested six crude plant extracts against adult Schistosoma mansoni, Fasciola hepatica, and Echinostoma caproni in vitro. Mortality was best achieved by ethanolic extracts of Artemisia annua (sweet Annie), Asimina triloba (paw-paw), and Artemisia absinthium (wormwood) which, at 2 mg/mL, killed S. mansoni and E. caproni in 20 h or less (except for wormwood), F. hepatica between 16 and 23 h (sweet Annie), or 40 h (paw-paw). Some extracts were active at 0.2 mg/mL and 20 μg/mL, although more time was required to kill trematodes. However, aqueous A. annua and methanol extracts of Fumaria officinalis had no activity. Chromatographic analysis of the three best extracts established that A. annua and A. triloba extracts contained bioactive artemisinin and acetogenins (asimicin and bullatacin), respectively. The anthelmintic activity of our extracts at such low doses indicates that their anthelmintic activity deserves further testing as natural alternative controls for parasites of both animals and humans. Our results also support recent evidence that synergistic effects of multiple bioactive compounds present in crude plant extracts is worth exploring.

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Herbal dewormer fails to control gastrointestinal nematodes in goats

Cited by 33 publications

References 12 publications

Assessing the usefulness of mineral licks containing herbal extracts with anti-parasitic properties for the control of gastrointestinal helminths in grazing sheep – a field trial

Assessing the usefulness of mineral licks containing herbal extracts with anti-parasitic properties for the control of gastrointestinal helminths in grazing sheep – a field trial

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis

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