Herbal Medications in Endodontics and Its Application—A Review of Literature

Karobari, Mohmed Isaqali; Adil, Abdul Habeeb; Assiry, Ali A; Basheer, Syed Nahid; Noorani, Tahir Yusuf; Marya, Anand; Messina, Pietro; Scardina, Giuseppe Alessandro

doi:10.3390/ma15093111

Cited by 18 publications

(10 citation statements)

References 69 publications

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“…They are considered to be healthier and more environmentally acceptable. 20 They are easy to obtain and are well accepted by the host with many useful pharmacological actions comparable with synthetic drugs.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis

Kameri¹,

Haziri²,

Hashani³

et al. 2023

CCIDE

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Purpose With the demand for better efficiency during endodontic therapy, the purpose of this in vitro study was to evaluate the efficiency of ethyl acetate (EthOAc) extract of Matricaria chamomilla (L.) against Enterococcus faecalis and compare with standard root canal irrigation solutions. Material and Methods The antibacterial effect against Enterococcus faecalis of the EthOAc extract of Matricaria chamomilla was assessed without, or with dentine powder, using agar disk diffusion method. The inhibition zones induced by the EthOAc extract were observed after 5 minutes, 60 minutes, and 24 hours and compared with standard irrigation solutions (2% chlorhexidine and 2% sodium hypochlorite) without, or after mixing with dentine powder. Statistical analysis of the results were analysed with the Kruskal–Wallis test and one-way ANOVA. Results There was no inhibition zone in samples with and without dentine powder after combination of ethyl acetate extract of Matricaria chamomilla with sodium hypochlorite. When the extract was used alone in samples without dentine powder, the inhibition zone was 9.7 mm after 24 h, but this zone was decreased after adding dentine powder (7.7 mm). When the extract was used in combination with CHX, the inhibition zone in samples with dentine powder was 25.3 mm, but it was decreased after adding dentine powder (21.7 mm). Conclusion The EthOAc extract of Matricaria chamomilla as alternative root canal irrigant may be a useful natural agent with antibacterial activity against Enterococcus faecalis . Also, it showed promising results in endodontic therapy after combination with chlorhexidine in Enterococcus faecalis eradication.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis

Kameri¹,

Haziri²,

Hashani³

et al. 2023

CCIDE

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“…Herbal materials are increasingly valued in dental and medical practice due to their antimicrobial, antioxidant, anti-inflammatory, and biocompatibility properties [ 1 ]. One of these medicinal plants is Moringa oleifera ( M. oleifera ) that belongs to the Moringaceae family and is commonly called horseradish or drumstick tree [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Leaf Extracts of Moringa oleifera Cultivated in Baghdad: Characterization and Antimicrobial Potential against Endodontic Pathogens

Shafiq,

Mahdee,

Mohammed Hasan

2024

The Scientific World Journal

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The use of medicinal plant preparations to clean and disinfect root canal infection is gaining popularity. The aim of this study was to evaluate the bioactive composition of leaf extracts of Moringa oleifera plants cultivated in Iraq (specifically Baghdad) and their antimicrobial activity against selected root canal pathogens for potential application in endodontic treatment. Materials and Methods. Moringa leaf extracts were prepared either through cold maceration or warm digestion techniques to perform an ethanolic or aqueous extraction, respectively. Phytochemical detection was performed before thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) to measure flavonoids and phenolic compounds within both extracts. Then, their antimicrobial activities were investigated against Streptococcus mutans, Enterococcus faecalis, and Candida albicans through minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and agar well diffusion assay in comparison to NaOCl and Ca(OH)2. Results. Phytochemical screening showed several active ingredients but with higher expression of flavonoids and phenolic compounds. Also, different types of these compounds were detected through TLC and quantified by HPLC. MIC values for ethanolic extract against Streptococcus mutans, Enterococcus faecalis, and Candida albicans were 60, 65, and 55, respectively, while for aqueous extract, MIC values were 70, 80, and 50, respectively. Aqueous extract showed a higher inhibition zone than ethanolic extract for both Streptococcus mutans and Enterococcus faecalis with a statistically significant difference (p≤0.001) for all tested materials except with NaOCl and Ca(OH)2 in Streptococcus mutans and Enterococcus faecalis, respectively. The ethanolic extract showed a higher inhibition zone against Candida albicans, with a statistically significant difference (p≤0.001) for all tested materials. Conclusion. Ethanolic and aqueous extracts of Moringa oleifera leaves cultivated in Baghdad contain considerable quantities of phytochemicals, especially flavonoid and phenolic compounds, and demonstrated antimicrobial activities against selected endodontic pathogens. Therefore, Moringa leaf extracts could be suggested as an alternative antimicrobial material in endodontic treatment.

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“…Yet, studies reported its limited action against Enterococcus faecalis and Candida albicans species which are main cause for failure of endodontic treatment (6,8,9) . Plant-derived natural biocompatible agents have strongly gained research interest in the endodontic field due to their markable antibacterial, antiinflammatory and antioxidant properties (10) . These agents have been widely investigated as better, safer, and more potent alternative intracanal medicaments to overcome the drawbacks of CH (11) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Propolis, Neem and Calcium Hydroxide as Intracanal Medicaments on the Sealing Ability of Resin-Based Endodontic Sealer

Hanafy

Fathallah

2023

Egyptian Dental Journal

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Aim: This in-vitro study was conducted to evaluate the effect of 2 herbal extracts (Propolis, Neem) and calcium hydroxide, when used as intracanal medicaments, on the sealing ability of resin-based endodontic sealer. Materials and Methods:A total of 60 extracted, human, permanent, single-rooted, maxillary, anterior teeth with fully formed apices and straight roots were collected for this study. All specimens were coronally resected to a standardized length of 15 ± 1 mm and root canals were mechanically prepared using crown down technique. The prepared teeth were divided into five groups: Group I, Positive control (teeth were instrumented but not root-canal filled); Group II, No intracanal medicament was used; Group III, Propolis gel was used; Group IV, Neem gel was used; Group V, Injectable calcium hydroxide was used. Intracanal medicaments were left for 7 days after which they were removed, and the specimens were obturated using gutta percha with AH Plus sealer by cold lateral compaction technique. Sealing ability was assessed using dye extraction method. Statistical analysis was carried out by one-way analysis of variance followed by Post-hoc Tukey test. Results:The results showed that propolis group had better sealing ability than neem group but with no significant difference. Both propolis and neem medicated groups had statistically higher sealing ability for AH Plus sealer when compared to the calcium hydroxide medicated group. Conclusion:The authors concluded that Propolis and Neem intracanal medicaments can be used as alternatives to calcium hydroxide without relatively affecting the obturated root canal final seal.

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Herbal Medications in Endodontics and Its Application—A Review of Literature

Cited by 18 publications

References 69 publications

Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis

Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis

Leaf Extracts of Moringa oleifera Cultivated in Baghdad: Characterization and Antimicrobial Potential against Endodontic Pathogens

Effect of Propolis, Neem and Calcium Hydroxide as Intracanal Medicaments on the Sealing Ability of Resin-Based Endodontic Sealer

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