Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Li, Yan; Martin, Robert C.G.

doi:10.1093/ecam/neq044

Cited by 64 publications

(40 citation statements)

References 88 publications

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“…HCC is considered to be a tumour which is highly resistant to agents attacking DNA. Several herbal composite formulas and natural components (Curcumin, Resveratrol, and Silibinin) have been shown to be beneficial for the cancer chemoprevention via inducing the DNA damage [ 22 ]. In the present study, for the first time we have reported the anti-proliferative and pro-apoptotic properties of the MP in hepatic cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells

Pant

Gupta

Damania

et al. 2016

BMC Complement Altern Med

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BackgroundMineral Pitch (MP) is a dark brown coloured humic matter originating from high altitude rocks. It is an Ayurvedic medicinal food, commonly used by the people of the Himalayan regions of Nepal and India for various body ailments.MethodsThe Huh-7 cells were treated with different concentrations of MP for 24 h, and both apoptosis and proliferation was determined by the TUNEL and MTT assays respectively. The formation of ROS and nitric oxide was analysed by DCFH-DA and Griess reagent respectively. The expression of miRNA-21 and miRNA-22 were checked by the real time PCR. Effect of miRNA-22 on proliferation and c-myc was studied by over-expressing miRNA-22 premiRs in Huh-7 cells.ResultsWe found that MP enhanced anti-cancer effects by inducing apoptosis and inhibiting proliferation. MP induced both ROS and NO, upon neutralizing them, there was a partial recovery of apoptosis and proliferation. MP also induced miRNA-22 expression, while miRNA-21 expression was inhibited. Over-expression of miRNA-22 resulted in a significant inhibition of proliferation. miRNA-22 directly targeted c-myc gene, thereby inhibited proliferation. These results clearly show that MP induces its anti-cancer activity by more than one pathway.ConclusionThe data clearly indicate that MP induced apoptosis via the production of ROS, and inhibited proliferation by inducing miRNA-22 and inhibiting miRNA-21 in Huh-7 cells.

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Section: Resultsmentioning

confidence: 99%

Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells

Pant

Gupta

Damania

et al. 2016

BMC Complement Altern Med

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“…Immunotherapy is still being explored [21]. The efficacy of tranditional Chinese medicine therapy for HCC is even less promising [22].…”

Section: Discussionmentioning

confidence: 99%

Distribution of tumor stage and initial treatment modality in patients with primary hepatocellular carcinoma

et al. 2017

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“… 11 Several herbal compounds and their composite formulas are well known and effective in both in vitro and in vivo models. 12 Despite reports on BJ as a valid cancer treatment, 13 , 14 whether or not its aqueous extract is useful against human liver cancer and the progenitor stem-like cells remained unknown. To address this topic, this study reported that low concentrations of aqueous extract of BJ not only inhibited the growth of liver cancer cells but also blocked tumor-initiating capacity of the derived spheroids.…”

Section: Introductionmentioning

confidence: 99%

The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis

Chen

Kim

Fan

et al. 2016

DDDT

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Being effective and relatively safe, the traditional Chinese medicinal herb Brucea javanica (BJ) has been valuable in curing patients in East Asia and its nearby regions for years. Recent reports suggested that the medicinal herb possesses broad antitumor activity against various cancer cells. This study evaluated whether low concentrations of BJ aqueous extract inhibited the growth of liver cancer cells. Experiments including flow cytometry and Western blot analysis established the development of apoptotic cell death after treatment. Further experiments evaluated the growth of the enriched spheroids. BJ not only reduced the expression of stem cell markers but also eliminated tumor spheroids by apoptotic death. The findings suggest BJ is a promising supplement to the current therapy regimen and highlight the opportunity of BJ as a practical avenue to suppress the growth of the stem cells in liver cancer.

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Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Cited by 64 publications

References 88 publications

Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells

Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells

Distribution of tumor stage and initial treatment modality in patients with primary hepatocellular carcinoma

The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis

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