Herbal medicine Banha-sasim-tang for the treatment of functional dyspepsia protocol for a systematic review of randomized controlled trials

Ko, Seok‐Jae; Cho, Soo-Ho; Kim, Keum-Ji; Kim, Jin-Sung; Na-yeon, Ha; Park, Jae-Woo

doi:10.1097/md.0000000000015760

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…The study protocol was registered in the International Prospective Register of Systematic Reviews. The registration number is CRD42019123285 (Ko et al, 2019). This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (Liberati et al, 2009).…”

Section: Protocol and Registrationmentioning

confidence: 99%

Herbal medicine, Banxia-xiexin tang, for functional dyspepsia: a systematic review and meta-analysis

Kim

Cho

et al. 2023

Front. Pharmacol.

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Background: The demand for complementary and alternative medicine for the management of functional dyspepsia (FD) is increasing due to the insufficient efficacy of conventional treatment options. In Asia, the Chinese herbal medicine formula Banxia-xiexin tang (BXT) has been used to treat FD.Methods: We searched 11 digital medical databases on 1 September 2021. Randomized controlled trials (RCTs) that investigated the efficacy of BXT or combination therapy (BXT plus Western medicines) for FD were selected. The outcome parameters were total clinical efficacy rate (TCE), motilin level, symptom checklist-90-revised (SCL-90-R), and visual analog scale (VAS) for dyspepsia and adverse events. Cochrane risk of bias tool 2.0 (RoB 2) was used for the quality assessment of included studies.Results: The meta-analysis comprised 57 RCTs with 5,525 participants. BXT was more efficacious, with a higher TCE than Western medicine. Combination therapy (BXT plus Western medicine) also resulted in a higher TCE than Western medicine. Combination therapy improved motilin levels and psychological symptoms to a greater extent than Western medicine, evidenced by a higher SCL-90-R score. However, no significant difference in VAS scores was observed between the BXT and placebo groups. BXT and combination therapy were associated with fewer adverse events than Western medicine or placebo.Conclusion: Our findings suggest that BXT and its combination therapy may be an effective and safe alternative treatment for FD. More RCTs with better methodologies are required to strengthen this evidence.Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019123285], identifier [CRD42019123285].

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Section: Protocol and Registrationmentioning

confidence: 99%

Herbal medicine, Banxia-xiexin tang, for functional dyspepsia: a systematic review and meta-analysis

Kim

Cho

et al. 2023

Front. Pharmacol.

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“…[ 16 , 17 ] The poor methodological quality of the meta-analysis and SRs did not provide sufficient evidence to allow application of the guidelines for the treatment of FD patients. Recently, 1 group reported a well-designed study protocol for an SR of RCTs that focused on BST for the treatment of FD, [ 49 ] but their results have not been reported yet. BST is a widely used TKM regimen for patients with FD; nevertheless, there is a paucity of credible evidence assessing its efficacy and safety in comparison with a placebo and other drugs used for FD in Western medicine.…”

Section: Main Bodymentioning

confidence: 99%

Complementary and alternative medicine for functional dyspepsia: An Asian perspective

Yoon¹,

Ko²,

Park³

et al. 2022

Medicine

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A considerable number of Asian patients with functional dyspepsia (FD) are searching for complementary and alternative medicine (CAM) because they are unsatisfied with conventional medical treatment. However, no article has focused on CAM for FD from Asian perspective. In Asian countries, many traditional herbal formulas, including Banha-sasim-tang, Soyo-san, Sihosogan-san, Yukgunja-tang, and Pyeongwi-san, are used in patients with FD. In the few blinded and placebo-controlled studies conducted, the weak evidence regarding the effectiveness of herbal prescriptions in patients with FD did not allow any conclusions to be made. The clinical efficacy and safety of STW-5 were proven in several prospective randomized controlled trials and systematic reviews. Hence, it was recently approved as a therapeutic option for the treatment of FD. Peppermint and caraway, FDgard, black seed oil, and Jollab have been used in patients with FD, but there is limited evidence supporting their use. Reviews of acupuncture in patients with FD showed inconsistent results: a Cochrane review reported a negative result, while other meta-analyses reported positive results. Psychotherapy, including hypnotherapy, psychoanalytic psychotherapy, and cognitive behavioral therapy, may be used in patients with FD, although it is only supported by weak evidence. Therefore, well-planned, large-scale studies are necessary to evaluate the efficacy of CAM in treating FD, especially in Asian countries.

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“…In clinical practice, the most commonly used TCMs for FD are Banhasasim-tang (半夏泻心汤, known as Ban Xia Xie Xin decoction in China and Hange-shashin-to in Japan) and Yukgunja-tang (六君子汤, known as Liu Jun Zi decoction in China and Rikkunshito in Japan). Due to their widespread use, these two decoctions have been widely studied in both clinical and preclinical studies [ 79 , 80 ]. Clinical practice guidelines for FD published in Japan recommend the use of Yukgunja-tang as a second-line treatment with evidence level A [ 81 ].…”

Section: Two Representative Tcms Modulating Icc: Banhasasim-tang (半夏泻心汤) and Yukgunja-tang (六君子汤)mentioning

confidence: 99%

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Joung

Choi²,

Son

2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. The pathophysiology of functional dyspepsia (FD) remains uncertain, but the interstitial cells of Cajal (ICCs), pacemakers that regulate gastrointestinal motility, are garnering attention as key modulators and therapeutic targets in FD. This review comprehensively discusses the involvement of ICCs in the pharmacologic actions of FD and as therapeutic targets for herbal products for FD. Methods. A search of the literature was performed using PubMed by pairing “interstitial cells of Cajal” with “medicinal plant, herbal medicine, phytotherapy, flavonoids, or traditional Chinese medicine (TCM).” Results. From the 55 articles screened in the initial survey, 34 articles met our study criteria. The search results showed that herbal products can directly depolarize ICCs to generate pacemaker potentials and increase the expression of c-kit and stem cell factors, helping to repair ICCs. Under certain pathological conditions, medicinal plants also protect ICCs from oxidative stress and/or inflammation-induced impairment. Two representative herbal decoctions (Banhasasim-tang, 半夏泻心汤, and Yukgunja-tang, 六君子汤) have been shown to modulate ICC functions by both clinical and preclinical data. Conclusion. This review strongly indicates the potential of herbal products to target ICCs and suggests that further ICC-based studies would be promising for the development of FD treatment agents.

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Herbal medicine Banha-sasim-tang for the treatment of functional dyspepsia protocol for a systematic review of randomized controlled trials

Cited by 7 publications

References 15 publications

Herbal medicine, Banxia-xiexin tang, for functional dyspepsia: a systematic review and meta-analysis

Herbal medicine, Banxia-xiexin tang, for functional dyspepsia: a systematic review and meta-analysis

Complementary and alternative medicine for functional dyspepsia: An Asian perspective

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

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