Herbal Medicine for General and Disuse Osteoporosis

Leung, Ping Chung

doi:10.4172/2329-9509.1000179

Cited by 1 publication

(1 citation statement)

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“…Due to the serious side effects of currently available medicines and treatments, research is focused toward herbal molecules to identify potential candidate molecules or formula, which can suppress the condition of osteoporosis effectively [ 37 ]. Many herbals are studied till the clinical level for their anti-osteoporotic effects [ 38 ]. The present study was conducted with one such herb, LG, to elucidate its effects on candidate genes and proteins involved in the signaling pathway of the Saos-2 osteoblastic cell line.…”

Section: Discussionmentioning

confidence: 99%

Molecular insights for an anti-osteoporotic properties of Litsea glutinosa on Saos-2 cells: An in-vitro approach

Changani

Parikh

2022

Journal of Ayurveda and Integrative Medicine

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Osteoporosis is a skeletal disease that is identified by the deterioration of micro-architecture of bone tissue, leading to enhanced bone brittleness and a consequential increase in fracture threat. There are many treatments available for osteoporosis such as bisphosphonate therapy, hormonal replacement therapy, herbal therapy etc. For decades, there are several herbs that are attributed to have anti-osteoporotic effects however the candidate genes involved in it remained unknown. In line with this, the present study is focused to elucidate the anti-osteoporotic property of Litsea glutinosa (LG). To understand the proliferative effect and identify involved players, gene expression was studied on the Saos-2 osteocytes in-vitro . The expression profile of candidate genes involved in different signaling pathways such as Egr-2, RUNX2, MAPK3, NFATc1, CREB, ERβ, along with proliferation and apoptotic markers in osteoporosis were selected for the study. The gene expression profile demonstrated a significant up-regulation of Egr-2, RUNX2, MAPK3, CREB, EBβ in the range of 1.5–2.2 folds, whereas NFATc1 was found to be down-regulated up to 0.4 times compared to control when treated with 250 μg/mL of LG. Besides this, anti-apoptosis effect of LG was also supported by flow cytometry results which also proved that LG induces proliferation and inhibits apoptosis, suggesting the proliferative role of LG. In conclusion, the present study gathers the potency of LG extract for its proliferative and anti-apoptotic effect on Saos-2 osteocytes and opens a new avenue for detailing the mechanistic actions of it on mitigating the pathophysiology of osteoporosis.

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Section: Discussionmentioning

confidence: 99%