Herbal Medicine for Stroke

ZimmermanClaire,; YarnellEric,

doi:10.1089/act.2018.29186.eya

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…Zimmerman and Yarnell reported that HMs might be a new and effective way to prevent and treat ischemia and hemorrhagic stroke. [6] Furthermore, Gaire introduced a potential HM treatment mechanism for ischemic stroke. [9] Stroke is a disease with sequelae and a high recurrence risk.…”

Section: Discussionmentioning

confidence: 99%

“…Once the “golden time” for applying tissue-plasminogen activators has passed, very little can be done to treat strokes. [6] Therefore, patients with stroke are often dissatisfied with their progress and seek complementary or alternative interventions, such as HMs. [7]…”

Section: Discussionmentioning

confidence: 99%

“…Once the "golden time" for applying tissue-plasminogen activators has passed, very little can be done to treat strokes. [6] Therefore, patients with stroke are often dissatisfied with their progress and seek complementary or alternative interventions, such as HMs. [7] Evidence supporting alternative medicine is growing, and many researchers are investigating the effectiveness of HMs for treating stroke.…”

Section: Discussionmentioning

confidence: 99%

“…The liver injury types were classified as: hepatocellular: R ≥ 5, cholestatic R ≤ 2 or mixed: 2 < R < 5. Subsequently, based on the RUCAM score, a causal relationship between the drug (CM or HM) and the liver injury event was assigned: highly probable (>9), probable (6)(7)(8), possible (3)(4)(5), unlikely (1-2), or excluded (≤0). [4] If the results were not within a normal range and did not fit the liver injury criteria, they were classified as liver test abnormalities.…”

Section: 22mentioning

confidence: 99%

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Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study

Kim

Jang

2022

Medicine

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In Korea, herbal medicines (HMs) are primarily used to treat diseases. Patients with stroke are generally older and take several conventional medicines (CMs) to address other underlying diseases, which is known as polypharmacy. Therefore, there is a growing concern about hepatotoxicity and nephrotoxicity due to drug interactions between HMs and CMs. Therefore, this study retrospectively investigated liver and renal tests in patients with stroke treated with polypharmacy to clarify the safety of simultaneous HM and CM administration. The medical records of 111 patients with stroke treated at a single center and who met the inclusion criteria between March 1, 2017, and March 1, 2022, were reviewed. The HMs and HM prescription frequency, CMs, and liver and kidney test results were recorded. Additionally, the Roussel Uclaf Causality Assessment Method and Kidney Disease Improving Global Outcome scores were documented, which are standard criteria for assessing liver and kidney injury, respectively. The study included 53 men and 58 women (average age: 67.8 years). On average, the patients took 6 types of CMs. No patient showed liver injury during the co-administration of CMs and HMs. Only 1 patient had initial hepatic damage but recovered after taking HMs. Furthermore, 2 patients had liver test abnormalities 2 times the upper limit of normal, possibly from Seogyeong-tang and atorvastatin, with Roussel Uclaf Causality Assessment Method scale scores of 3 and 5, respectively. No patient had a renal injury. HM is safe for patients with stroke taking multiple CMs. However, consulting an HM expert is essential to avoid hepatotoxicity, nephrotoxicity, and other adverse effects. These results highlight the benefits of Korea’s dual medical system.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: 22mentioning

confidence: 99%

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Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study

Kim

Jang

2022

Medicine

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Insights into the neuroprotective strategies to alleviate neurodegenerative conditions: Role of Ayurvedic herbs and their bioactives

Malhotra

Sandhir

2023

Ayurvedic Herbal Preparations in Neurological Disorders

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Oxidative stress in cerebrovascular disease and associated diseases

et al. 2023

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Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously, oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance between reactive oxygen and nitrogen species and the antioxidant defense system. Emerging evidence indicates that OS is a common cause of several age-related brain pathologies, including cerebrovascular diseases. Elevated OS disrupts endothelial functional ability by diminishing the bioavailability of nitric oxide (a vascular dilator), induces atherosclerosis, and impairs vasculature, which are all common characteristics of cerebrovascular disease. In this review, we summarize evidence supporting an active role of OS in cerebrovascular disease progression, focusing primarily on stroke pathogenesis. We briefly discuss hypertension, diabetes, heart disease, and genetic factors that are often linked to OS and are considered associated factors influencing stroke pathology. Finally, we discuss the current pharmaceutics/therapeutics available for treating several cerebrovascular diseases.

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Herbal Medicine for Stroke

Cited by 3 publications

References 52 publications

Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study

Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study

Insights into the neuroprotective strategies to alleviate neurodegenerative conditions: Role of Ayurvedic herbs and their bioactives

Oxidative stress in cerebrovascular disease and associated diseases

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