Herbal medicine for the management of postoperative pain

Park, Kyung Moo; Kim, Ji Hwan

doi:10.1097/md.0000000000014016

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Taken together, the negative side effects associated with neuropathic and postoperative pain treatment reinforce the recommendations of evidence-based alternative therapeutics to treat these aforementioned pain conditions. Natural products, including herbals, flavonoids, and polyphenols, remain one of the most promising treatments for neuropathic [ 11 , 12 , 13 , 14 , 15 , 16 ] and postoperative pain [ 17 , 18 ]. Curcumin, also known as diferuloylmethane, is a polyphenolic compound present in the rhizomes of Curcuma longa (syn.…”

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confidence: 99%

Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

Basu

Maier

Basu

2021

IJMS

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Lesion or disease of the somatosensory system leads to the development of neuropathic pain. Peripheral neuropathic pain encompasses damage or injury of the peripheral nervous system. On the other hand, 10–15% of individuals suffer from acute postoperative pain followed by persistent pain after undergoing surgeries. Antidepressants, anticonvulsants, baclofen, and clonidine are used to treat peripheral neuropathy, whereas opioids are used to treat postoperative pain. The negative effects associated with these drugs emphasize the search for alternative therapeutics with better efficacy and fewer side effects. Curcumin, a polyphenol isolated from the roots of Curcuma longa, possesses antibacterial, antioxidant, and anti-inflammatory properties. Furthermore, the low bioavailability and fast metabolism of curcumin have led to the advent of various curcumin formulations. The present review provides a comprehensive analysis on the effects of curcumin and its formulations in preclinical and clinical studies of neuropathic and postoperative pain. Based on the positive outcomes from both preclinical and clinical studies, curcumin holds the promise of mitigating or preventing neuropathic and postoperative pain conditions. However, more clinical studies with improved curcumin formulations are required to involve its use as adjuvant to neuropathic and postoperative drugs.

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