Herbal medicine in oral lichen planus

Ghahremanlo, Atefeh; Boroumand, Nadia; Ghazvini, Kiarash; Hashemy, Seyed Isaac

doi:10.1002/ptr.6236

Cited by 24 publications

(21 citation statements)

References 37 publications

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“…Different amounts of free radicals and reactive oxygen species (ROS) are induced during this process. These reactions can damage lipids, proteins, and nucleic acids in cells [ 12 , 22 ]. OLP (as a potentially malignant disorder) symptoms, along with its classification, mandates effective management and regular monitoring [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial

Kia

Basirat

Mortezaie

et al. 2020

BMC Complement Med Ther

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Background Oral lichen planus (OLP) is a mucocutaneous autoimmune disease with T-cell mediation. Corticosteroids are considered as a first choice in OLP and should be used for a long period with a subsequent increase in dose since the disease has a chronic and recalcitrant nature. There have been efforts to use alternative therapies due to the Corticosteroid’s side effects. Curcumin is a non-toxic natural product with different effects on various oral diseases. It demonstrates antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities. It seems that Curcumin can be used as a proper alternative for Corticosteroid treatments. To overcome limitations in the bioavailability of Curcumin, the therapeutic effect of oral Nano-Curcumin was evaluated for the first time. Methods Sixty OLP patients were included in this double-blinded randomized clinical trial. The patients were randomly divided into two groups and received either ‘Nano-Curcumin 80 mg’ or ‘Prednisolone 10 mg’ treatments for 1 month. The patients should take one capsule after having their breakfast. The VAS scale was used to analyze pain severity and burning sensation. To assess lesion size the Thongprasom scale was employed. Repeated measures and independent t-tests, as well as LSD paired-test, were used to analyze the data. Results Data from 57 patients were analyzed. The level of pain, burning sensation, and OLP lesions decreased in both groups of Curcumin and Prednisolone and no statistically significant difference was observed between the two groups. Conclusion Despite many studies conducted to find an effective approach for managing OLP, the results have often been unsatisfactory. In comparison with previous studies, current results clarify the importance of Nano-Curcumin bioavailability in therapeutic effects. Pain VAS and lesion size were decreased with oral Curcumin. The results have shown that oral Curcumin can be used as an alternative therapy for OLP in patients with the contraindicated Corticosteroids or should be used with caution. Oral Curcumin can be used in preventing the recurrence of OLP lesions after the treatment and initial control. Moreover, the amount of Curcumin dose is more important than its use duration in improving OLP. Trial registration IRCT, IRCT20100101002950N5. Registered 9 February 2019, https://www.irct.ir/trial/36704.

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Section: Discussionmentioning

confidence: 99%

“…As a result, researchers have been continuously looking for a substitute natural or herbal drug to be taken as monotherapy or in combination with the first choice drugs [ 12 ]. These experts have been searching for drugs that could be taken in the treatment of lichen planus on a long-term basis with minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial

Kia

Basirat

Mortezaie

et al. 2020

BMC Complement Med Ther

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“…However, further scientific analysis is required to validate thier efficacy. 28,29 MMP, like pemphigus vulgaris, are vesiculobullous diseases, which are autoimmune, inflammatory, and chronic diseases characterized by formation of subepithelial bubbles and linear deposition of IgG, IgA, or C3 along the basement membrane area. Lesions usually affect oral, conjunctival, genital, and digestive mucosa; however, skin manifestations are rare.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Oral Lesions in Dermatological Diseases: A Retrospective Study

Teixeira‐Souza

Pessôa

Ramos

et al. 2020

Rev. Bras. Odontol.

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Objetivo: Este estudo teve como objetivo estabelecer a prevalência das lesões orais nas doenças dermatológicas. Material e Métodos: A população do estudo consistiu de 119 pacientes com dermatoses (conforme prontuário). Os dados demográficos e clínicos coletados incluem sexo, cor da pele, idade do diagnóstico e localização anatômica de lesão. Resultados: Prevalência significativa do sexo feminino (n = 74; 63%; p = 0,01) e cor de pele branca (n=7; 65%; p<0,001). A idade do diagnóstico variou de 10 a 86 anos, com alta prevalência de indivíduos >20 anos (n= 6; 73%; p=0,05). A lesão mais frequente foi o pênfigo vulgar (38%), seguido de líquen plano oral (30%); Penfigóide (17%); Lúpus Eritematoso (10%); Eritema multiforme e Epidermólise bolhosa (3%); Estomatite Ulcerativa Crônica e Pioestomatite vegetante (1%). Conclusão: As doenças dermatológicas podem afetar a mucosa oral, causando impacto significativo na qualidade de vida dos pacientes, o que compreendeu principalmente a população jovem em nosso estudo. O pênfigo vulgar foi a doença mais prevalente. O monitoramento contínuo por uma equipe multidisciplinar é essencial, uma vez que esse grupo de doenças não tem cura e/ou prognóstico variável.

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“…Herbal medicine has been shown to have anti-inflammatory properties with favorable impacts on immune function and could play a critical role in complementing drug therapy [41]. The use of herbal medicine with anti-inflammatory properties also showed promising results in managing autoimmune diseases with oral manifestations, such as oral lichen planus, aphthous stomatitis, and Sjögren's syndrome, revealing the increasingly important role of herbal medicine in managing various inflammatory diseases [42][43][44].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

Integrative Medicine (Herbal Medicine Combined with Drug Therapy) for Behcet’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2021

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This review aimed to investigate the efficacy of integrative medicine (herbal medicine combined with drug therapy) in the treatment of Behcet’s disease (BD). Eleven databases were searched from their inception to 7 December 2020, for randomized control trials (RCTs) that reported the effects of integrative medicine in treating BD. The risk of bias was assessed using seven domain criteria from the Cochrane Collaboration tool. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence. The direction of the effect is also shown in the form of an albatross plot. Sixteen trials met the inclusion criteria and were analyzed. The overall risk of bias was determined to be uncertain. The meta-analysis showed a superior response rate with herbal medicine plus drug therapy (relative risk (RR) 1.19, 95% confidence interval (CI) 1.13 to 1.25, n = 1034, p < 0.00001, I2 = 0%, low certainty of evidence (CoE)) compared to drug therapy. Integrative medicine also lowered the recurrence rate after 2 months of follow-up (RR 0.27, 95% CI 0.09 to 0.76, n = 120, p = 0.01, I2 = 0%, low CoE). The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and skin lesions were also significantly improved using integrative medicine, but equivalent effects were seen for oral ulcers, genital ulcers, and eye inflammation. Minor adverse events were reported in both groups. Our findings suggest that herbal medicine combined with drug therapy is more effective for the treatment of BD than drug therapy alone. Although the type of drug therapy used varied across the studies, integrative medicine was shown to improve the total response rate, skin lesions, the ESR, and the CRP level. However, the overall risk of bias of the studies was concerning, and the CoE was low. Information on adverse events (AEs) was also insufficient. In addition, the number of studies included for data synthesis for most outcomes was small. Future studies with rigorous RCTs may help establish the efficacy of integrative medicine in the treatment of BD.

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Herbal medicine in oral lichen planus

Cited by 24 publications

References 37 publications

Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial

Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial

Prevalence of Oral Lesions in Dermatological Diseases: A Retrospective Study

Integrative Medicine (Herbal Medicine Combined with Drug Therapy) for Behcet’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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