Abstract:Premature ovarian failure (POF) is a disorder that occurs before the age of 40 among women and characterized by amenorrhea. POF usually occurs due to autoimmune disorders, X-chromosome disorders, viral infections, or after chemotherapeutic treatment. POF can be discovered either by histopathology or by using molecular techniques such as real-time PCR to measure the expression of miRNAs that has a role in POF development. Cyclophosphamide (CP) is a well-known chemotherapy used in the treatment of leukemia, lymp… Show more
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