Herbal medicine (Suoquan) for treating nocturnal enuresis

Lee, Yoo Been; Lee, Ju Ah; Jang, Soobin; Lee, Hye Lim

doi:10.1097/md.0000000000010391

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…However, there are rare clinical trials that concern Ephedra , notably with Chinese medicines containing Mahuang (Ephedrae herba). For example, trial NCT03733873 has evaluated the Ephedra -containing Chinese medicine Suoquan for the treatment of nocturnal enuresis 154 . Trial NCT00432991 evaluated the effect of intramuscular ephedrine on the incidence of nausea and vomiting in women during and after a Cesarean section.…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

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Ephedra species are among the most popular herbs used in traditional medicine for a long time. The ancient Chinese medical book “Treatise on Febrile Diseases” refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species. Ephedra species are utilized all over the world to treat symptoms of the common cold and coughs, and to combat major human diseases, such as asthma, cancers, diabetes, cardiovascular and digestive disorders, and microbial infections. This study aimed at identifying specific Ephedra species used traditionally in Morocco for therapeutic purposes. The plant parts, their preparation process, and the treated pathologies were identified and analyzed. The results revealed five ethnobotanically important species of Ephedra: Ephedra alata Decne, Ephedra altissima Desf., Ephedra distachya L., Ephedra fragilis Desf., and Ephedra nebrodensis Tineo. These species are used traditionally in Morocco for treating people with diabetes, cancer, rheumatism, cold and asthma, hypertension, influenza virus infection, and respiratory ailments. In addition, they are occasionally used as calefacient agents, to regulate weight, or for capillary care. Few studies have underlined the antibacterial and antioxidant activities of some of these Moroccan Ephedra species, but little information is available regarding the natural products at the origin of the bioactivities. Further phytochemical investigations and clinical data are encouraged to better support the use of these plants.

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

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“…In the present study, we explored the effects and potential mechanism of SQW on diabetic OAB by using STZ-induced T2DM mouse model. SQW is one of the most commonly traditional Chinese formula to treat various urinary system diseases in China for thousands of years (Lai et al, 2015), such as urinary incontinence, nocturnal enuresis and OAB symptom syndrome (Lai et al, 2016; Lee et al, 2018). And diabetic OAB has the same symptom like nocturia and urgency, SQW also was used to treat DBD or combined with other drugs in clinical (Liu and Lan, 2006; Chen et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9

et al. 2019

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Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 weeks high-fat diet (HFD) feeding, C57BL/6J mice were injected with streptozotocin (100 mg/kg) for four times. After 3 weeks, the diabetic mice were treated with SQW for another 3 weeks. Voided stain on paper assay, fasting blood glucose (FBG) test, and oral glucose tolerance test (OGTT) were conducted. Urodynamic test, tension test [α,β-methylene ATP, electrical-field stimulation (EFS), KCl, and carbachol] and histomorphometry were also performed. Western blot analysis and qPCR assays were used to quantify the expression levels of myosin Va and SLC17A9. Results: The diabetic mice exhibited decreased weight but increased water intake, urine production, FBG, and OGTT. No significant changes were observed after 3 weeks SQW treatment. Urodynamic test indicated that the non-voiding contraction (NVC) frequency, maximum bladder capacity (MBC), residual volume (RV), and bladder compliance (BC) were remarkably increased in the diabetic mice, whereas the voided efficiency (VE) was decreased as a feature of overactivity. Compared with the model mice, SQW treatment significantly improved urodynamic urination with decreased NVC, MBC, RV, and BC, and increased VE. Histomorphometry results showed that the bladder wall of the diabetic mice thickened, and SQW effectively attenuated the pathological alterations. The contract responses of bladder strips to all stimulators were higher in the DSM strips of diabetic mice, whereas SQW treatment markedly decreased the contraction response for all stimuli. Moreover, the protein and gene expression levels of myosin Va and SLC17A9 were up-regulated in the bladders of diabetic mice, but SQW treatment restored such alterations. Conclusion: T2DM mice exhibited the early phase of diabetic bladder dysfunction (DBD) characterized by OAB and bladder dysfunction. SQW can improve the bladder storage and micturition of DBD mice by mediating the protein and gene expression levels of myosin Va and SLC17A9 in the bladder, instead of improving the blood glucose level.

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“…However, there are rare clinical trials that concern Ephedra, notably with Chinese medicines containing Mahuang (Ephedrae herba). For example, trial NCT03733873 has evaluated the Ephedracontaining Chinese medicine Suoquan for the treatment of nocturnal enuresis [154]. Trial NCT00432991 evaluated the effect of intramuscular ephedrine on the incidence of nausea and vomiting in women during and after a Cesarean section.…”

Section: Clinical Trials With Ephedra-based Productsmentioning

confidence: 99%

Untitled

2024

Planta Med

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Ephedra plants are among the oldest and most popular herbs used in traditional medicine in China and Japan [1][2][3]. Ephedrae herba has long been used as both medicine and food [4,5]. It stands as an efficient anti-stroke herbal medicine [6]. Its use as a folk phytomedicine is mentioned in ancient medical books and traditional prescriptions [3]. For example, the ancient Chinese medical book "Treatise on Febrile Diseases" refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species [7], and a Latin textbook from the roman naturalist Pliny the Elder (Gaius Plinius Secundus, AD 23-79) underlined the use of Ephedra as follows: "it is given from black austere wine, crushed, for coughs, sighs, convulsions, and drinking" [8]. For decades, Ephedra species have provided herbal remedies to treat human diseases [9,10]. These medicinal

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Herbal medicine (Suoquan) for treating nocturnal enuresis

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 17 publications

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9

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