Herbal medicine to cure male reproductive dysfunction

Fatma, Homa; Siddique, Hifzur R.

doi:10.1016/b978-0-323-90572-5.00023-8

Cited by 2 publications

(2 citation statements)

References 80 publications

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“…Plants are rich sources of bioactive compounds, and the secondary metabolites that are present in plants have shown excellent interspecies interaction, which can modulate the expression of various human proteins [107]. The use of phytochemicals as anticancer agents represents many bioactive compounds that have shown lesser side effects than conventional chemotherapeutic agents [108].…”

Section: Chemosensitization Of Prostate Cancer With Phytochemicalsmentioning

confidence: 99%

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Molecular Insight into Prostate Cancer: Preventive Role of Selective Bioactive Molecules

Jameel,

Fatma,

Nadtochii

et al. 2023

Life

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Prostate cancer (CaP) is one of the most prevalent male malignancies, accounting for a considerable number of annual mortalities. However, the prompt identification of early-stage CaP often faces delays due to diverse factors, including socioeconomic inequalities. The androgen receptor (AR), in conjunction with various other signaling pathways, exerts a central influence on the genesis, progression, and metastasis of CaP, with androgen deprivation therapy (ADT) serving as the primary therapeutic strategy. Therapeutic modalities encompassing surgery, chemotherapy, hormonal intervention, and radiotherapy have been formulated for addressing early and metastatic CaP. Nonetheless, the heterogeneous tumor microenvironment frequently triggers the activation of signaling pathways, culminating in the emergence of chemoresistance, an aspect to which cancer stem cells (CSCs) notably contribute. Phytochemicals emerge as reservoirs of bioactive agents conferring manifold advantages against human morbidity. Several of these phytochemicals demonstrate potential chemoprotective and chemosensitizing properties against CaP, with selectivity exhibited towards malignant cells while sparing their normal counterparts. In this context, the present review aims to elucidate the intricate molecular underpinnings associated with metastatic CaP development and the acquisition of chemoresistance. Moreover, the contributions of phytochemicals to ameliorating CaP initiation, progression, and chemoresistance are also discussed.

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Section: Chemosensitization Of Prostate Cancer With Phytochemicalsmentioning

confidence: 99%

“…the expression of various human proteins [107]. The use of phytochemicals as anticancer agents represents many bioactive compounds that have shown lesser side effects than conventional chemotherapeutic agents [108].…”

Section: Curcuminmentioning

confidence: 99%

Molecular Insight into Prostate Cancer: Preventive Role of Selective Bioactive Molecules

Jameel,

Fatma,

Nadtochii

et al. 2023

Life

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Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats

Parsania,

Salehpoor,

Sadrr Ameli

et al. 2024

Crescent J Med Biol Sci

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Objectives: This study aims to comprehensively assess the therapeutic potential of clove extract in mitigating testicular damage and preserving male reproductive function under hypoxic conditions in male rats. Materials and Methods: We randomly divided 24 male rats into three groups: a hypoxia group that just received normal saline, a hypoxia + clove extract (4 mg/kg) group, and a sham operation group without treatment. After eight weeks, the serum level of oxidative stress parameters was examined, and the testicle histopathological examination, such as seminiferous tubule diameters and epithelium thickness, was assessed. Results: The serum malondialdehyde (MDA) concentration was significantly enhanced in the hypoxic group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) declined (P<0.05). The diameters and thickness of the seminiferous tubule were diminished notably (P<0.05). Johnson’s score decreased in the hypoxic group. Treatment with clove extract also led to improvements in this parameter. Conclusions: Our study provides compelling evidence for the therapeutic potential of clove extract in mitigating testicular injury associated with varicocele-induced testicular hypoxia in male rats.

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Herbal medicine to cure male reproductive dysfunction

Cited by 2 publications

References 80 publications

Molecular Insight into Prostate Cancer: Preventive Role of Selective Bioactive Molecules

Molecular Insight into Prostate Cancer: Preventive Role of Selective Bioactive Molecules

Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats

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