Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review

Wang, H B; Gu, Yanqiu; Rahman, Khalid; Chen, Xiaofei; Han, Ting

doi:10.1016/s1875-5364(23)60405-4

Cited by 8 publications

(4 citation statements)

References 128 publications

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“…Tan IIA has the highest response and is abundant in the S. miltiorrhiza ethanol extract. , So we selected Tan IIA to further verify the screening results. Tan IIA standard compound was injected into the PDGFRβ affinity chromatographic columns.…”

Section: Resultsmentioning

confidence: 99%

One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands

Wang,

Gu,

Chen

et al. 2024

Anal. Chem.

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Accurate orientations and stable conformations of membrane receptor immobilization are particularly imperative for accurate drug screening and ligand−protein affinity analysis. However, there remain challenges associated with (1) traditional recombination, purification, and immobilization of membrane receptors, which are time-consuming and labor-intensive; (2) the orientations on the stationary phase are not easily controlled. Herein, a novel one-step synthesis and oriented-immobilization membrane-receptor affinity chromatography (oSOMAC) method was developed to realize high-throughput and accurate drug screening targeting specific domains of membrane receptors. We employed Strep-tag II as a noncovalent immobilization tag fused into platelet-derived growth factor receptor β (PDGFRβ) through CFPS, and meanwhile, the Strep−Tactin-modified monolithic columns are prepared in batches. The advantages of oSOMAC are as follows: (1) targeted membrane receptors can be expressed independent of living cell within 1−2 h; (2) orientation of membrane receptors can be flexibly controlled and active sites can expose accurately; and (3) targeted membrane receptors can be synthesized, purified, and orientationimmobilized on monolithic columns in one step. Accordingly, three potential PDGFRβ intracellular domain targeted ligands: tanshinone IIA (Tan IIA), hydroxytanshinone IIA, and dehydrotanshinone IIA were successfully screened out from Salvia miltiorrhiza extract through oSOMAC. Pharmacological experiments and molecular docking further demonstrated that Tan IIA could attenuate hepatic stellate cells activation by targeting the protein kinase domain of PDGFRβ with a K D value of 9.7 μM. Ultimately, the novel oSOMAC method provides an original insight for accurate drug screening and interaction analysis which can be applied in other membrane receptors.

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Section: Resultsmentioning

confidence: 99%

One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands

Wang,

Gu,

Chen

et al. 2024

Anal. Chem.

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“…The examination of the substance composition across different parts revealed that the sour date fruit kernel (ZSS group) comprised the following compounds: (1) magnoflorine, (2) spinosin, (3) rutin, (4) 6 ′′′ -feruloylspinosin, (5) Jujuboside A1, (6) Jujuboside A, (7) Jujuboside B, (8) betulinic acid, (9) ceanothic acid, and (10) alphitolic acid. ZSF contained compounds (1), ( 2), (3), and (7-10), while ZSKS contained compounds (1) and (8)(9)(10). The common substance basis for the sedative and hypnotic effects of various parts of ZS may be the presence of compounds (1), ( 8), (9), and (10) across all parts of ZS.…”

Section: Saponinmentioning

confidence: 99%

“…ZSF contained compounds (1), ( 2), (3), and (7-10), while ZSKS contained compounds (1) and (8)(9)(10). The common substance basis for the sedative and hypnotic effects of various parts of ZS may be the presence of compounds (1), ( 8), (9), and (10) across all parts of ZS. The substance basis for the higher efficacy of ZSS than ZSF and ZSKS may be due to the presence of compounds (4), (5), and (6) in ZSS, which are not present in ZSF and ZSKS.…”

Section: Saponinmentioning

confidence: 99%

“…5-HT, recognized as the “pleasure neurotransmitter”, exerts its functions within the brain through its extensive family of receptors. Notably, the 5-HT1 subfamily has emerged as a crucial target for therapeutic medications aimed at addressing psychiatric disorders [ 9 , 10 , 11 ]. GABA serves as a critical inhibitory neurotransmitter within the central nervous system (CNS), with the GABA A-type receptor (GABAAR) being mainly associated with insomnia symptoms [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of the Sedative and Hypnotic Effects among Various Parts of Zizyphus spinosus Hu and Their Chemical Analysis

Li,

Yang,

Song

et al. 2024

Pharmaceuticals

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Zizyphus spinosus Hu (ZS), as a “medicinal and food-homologous” plant, has been used for a long history. The study was to assess the sedative and hypnotic effects among various parts of ZS. The model, diazepam (DZP), ZS kernel (ZSS), ZS flesh (ZSF), and ZS husk (ZSKS) group occurred subsequent to the successful establishment of the para-chlorophenylalanine induced insomnia model via intraperitoneal injection. The latency and duration of sleep in mice in each group were recorded. The substance basis of various parts of ZS was analyzed by the UPLC-QTOF-MS technique. The results showed that relative to the model group, DZP, ZSS, ZSF, and ZSKS groups demonstrated shortened sleep latency (p < 0.05) and extended sleep duration (p < 0.01). The GABA, 5-HT, and BDNF levels were significantly upregulated in the brain tissues of the mice in the DZP, ZSF, and ZSS groups (p < 0.01). However, the improvement in ZSKS was non-significant. Additionally, the mRNA and protein expression levels of 5-HT1AR, GABAARα1, and BDNF in mice in the DZP, ZSS, and ZSF groups were significantly enhanced (p < 0.01). However, the improvement in the ZSKS group was insignificant (p < 0.05). The examination of the substance composition across different parts revealed that the shared chemical basis contributing to the sedative and hypnotic potency of different parts of ZS may involve the presence of compounds such as (1) magnoflorine, (8) betulinic acid, (9) ceanothic acid, and (10) alphitolic acid. It provides a basis for further elucidation of the substance basis responsible for the functional and medicinal effects of ZS.

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Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics

Zhang,

Ren,

Ding

et al. 2024

Biomedical Chromatography

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Given the genetic and clinical overlap observed between schizophrenia and depression, the present study was to identify the similarities and differences in serum metabolic profiles between patients with schizophrenia and depression. Global metabolomics research methods based on UHPLC‐QTOF‐MS/MS were performed. A total of 113 and 118 differential metabolites were screened and identified in depression and schizophrenia groups, respectively, as compared to health control; among those, 94 differential metabolites were shared by both. Pathway analysis indicated arginine and proline metabolism, alanine, aspartate, and glutamate metabolism were two significant metabolic pathways both in depression and schizophrenia groups as compared with health control groups, respectively. Similarly, 77 differential metabolites were identified between depression and schizophrenia groups, in which, serum N‐acetylglutamine and isovalerylglycine levels showed significant differences between patients with depression and schizophrenia with p values less than 0.001 and without significant outliers. Sphingolipid metabolism was identified as a significant metabolic pathway distinguishing between depression and schizophrenia groups based on pathway analysis. Conclusively, common alterations in arginine and proline metabolism, alanine, aspartate, and glutamate metabolism were observed in patients with schizophrenia and depression; whereas differences in serum N‐acetylglutamine and isovalerylglycine levels as well as sphingolipid metabolism were discovered between the two categories of patients.

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Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review

Cited by 8 publications

References 128 publications

One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands

One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands

Comparative Analysis of the Sedative and Hypnotic Effects among Various Parts of Zizyphus spinosus Hu and Their Chemical Analysis

Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics

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