Herbal medicines from ginkgo leaf extract in the treatment of mild dementia

Petrović, Slobodan S.; Ušjak, Ljuboš

doi:10.5937/arhfarm2002081p

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…As a botanical food supplement, products made from dried G. biloba extract are the bestselling herbal products, especially in Europe [156] . It is worth pointing out that a rigorous evaluation of G. biloba extracts by the European Medical Agency (EMA) has led to the ginkgo leaf extract is indicated for the improvement of (age-associated) cognitive impairment and of quality of life in mild dementia [157] .…”

Section: Terpenoidsmentioning

confidence: 99%

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Li,

Wei,

Liang

et al. 2024

Food Science and Human Wellness

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Alzheimer's disease (AD), the major form of neurodegenerative diseases that can severely impede normal cognitive function, makes it one of the most common fatal diseases. There are currently over 50 million AD patients worldwide. The neuropathology of AD is perplexing and there is a scarcity of disease-modifying treatments. Currently, early diagnosis of AD has been made possible with the discovery of biological markers associated with pathology, providing strong support for the improvement of the disease status. The search for inhibitors of AD markers from dietary supplements (DSs) has become a major hot topic. Especially with the widespread use of DSs, DSs containing polyphenols, alkaloids, terpenes, polysaccharides and other bioactive components can prevent AD by reducing Aβ deposition, inhibiting tau protein hyperphosphorylation, reconstructing synaptic dysfunction, weakening cholinesterase activity, regulating mitochondrial oxidative stress, neuronal inflammation and apoptosis. This review summarizes the anti-AD effects of the main DSs and their bioactive constituents, as well as the potential molecular mechanisms covers from 2017 to 2023. Additionally, we discussed the opportunities and challenges faced by DSs in the process of AD prevention and treatment, aiming to further provide new perspectives for functional food development.

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Section: Terpenoidsmentioning

confidence: 99%

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Li,

Wei,

Liang

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…Eur. ), the extract should contain 22.0-27.0% of flavonoids, 2.8-3.4% of ginkgolides A, B, and C, and 2.6-3.2% of bilobalide (active constituents), and a maximum of 5 ppm ginkgoid acids (potential allergens) (13). Treatment with Ginkgo biloba extracts is safe, but close attention should be paid to patients being treated with anticoagulants, as the pharmacokinetics of some may be altered by certain plant extracts (14).…”

Section: Neuroprotective Effects Of Ginkgo Bilobamentioning

confidence: 99%

Natural Products for Neurocognitive Disorders

Servello

Leccese

Ettorre

2020

Alzheimer’s Disease: Drug Discovery

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Neurocognitive disorders are devastating. In 2016, 43.8 million people were estimated to have Alzheimer' s disease worldwide. By 2050, this figure is expected to rise by 56%. Despite the extreme importance of the disease, the weapons available to us to combat it are very scarce. Natural substances may be a worthwhile option for the treatment and management of neurocognitive disorders. Some of these natural products have been shown to be capable of positively impacting memory, behavior, and functions of patients with Alzheimer' s disease. These substances act on the disease mainly through antioxidant properties, the ability to eliminate oxygen radicals, the capacity to influence cell survival and programmed cell death, and the potential to condition amyloidogenesis. This chapter provides an overview of our current knowledge on the potential of natural products to be effective neuroprotective agents for Alzheimer' s disease. Current evidence on Ginkgo biloba, bacopia, resveratol, curcumin, quercetin, kaempferol, capsaicin, and berberine, along with their adverse effects and drug interactions are discussed.

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Herbal medicines from ginkgo leaf extract in the treatment of mild dementia

Cited by 2 publications

References 61 publications

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Natural Products for Neurocognitive Disorders

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