2019
DOI: 10.1002/ptr.6519
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Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action

Abstract: The research for new treatments of skin and soft tissue infections (SSTIs) is important due to their high prevalence and number of hospitalizations. The purpose of this review is to address the pathophysiology of SSTIs to highlight the advantages of herbal medicines to their treatment, showing examples of species and compounds with multi‐targets action. SSTIs have a complex physiopathology involving the microorganism, as well as inflammation and difficult healing. Therefore, antimicrobial, anti‐inflammatory, a… Show more

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Cited by 24 publications
(20 citation statements)
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References 80 publications
(57 reference statements)
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“…Moreover, the scavenging of free radicals could prevent bacterial skin infections, since bacterial infections depend also on oxidative stress [59]. The oxidative stress can increase the infection severity and could disturb wound healing [60]. Due to the high antioxidant activity and the content of valuable compounds, E. angustifolium extracts can be included in dermatological and cosmetic preparations, having positive effects on the skin [31,61].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the scavenging of free radicals could prevent bacterial skin infections, since bacterial infections depend also on oxidative stress [59]. The oxidative stress can increase the infection severity and could disturb wound healing [60]. Due to the high antioxidant activity and the content of valuable compounds, E. angustifolium extracts can be included in dermatological and cosmetic preparations, having positive effects on the skin [31,61].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the pathophysiology of SSTIs is the result of a complex interplay of physiological, immunological, and environmental effects, including microorganism, inflammation, oxidative stress, and impaired healing. In immunocompetent hosts, SSTIs can be caused by various microorganisms, mainly bacteria and fungi 1 3 .…”
Section: Introductionmentioning
confidence: 99%
“…Acanthospermum australe (Loefl.) Kuntze, commonly known as "tapekué" in Argentina, is a medicinal plant used by indigenous peoples in northeastern Argentina to disinfect wounds and skin ulcers, among other uses 3 , 14 , 15 . In addition, silver is used in traditional Indian medicine (Ayurveda) as a therapeutic agent to treat various infections 16 .…”
Section: Introductionmentioning
confidence: 99%
“…It is important to emphasize that although many terpene compounds have descriptions of therapeutic activity correlated to a plant, in many cases it is not possible to attribute that the activity manifested can be caused by only one substance. In some cases, more than one substance acts synergistically in the manifestation of the biological effect (Amparo et al., 2019; Caesar & Cach, 2019; Carmona & Pereira, 2013). Zhu, Dai, Yang, and Qiu (2013) evaluated the ovicidal and larvicidal activity of essential oil and two isolated monoterpenes (1,8‐cinoleol and camphor) of the Artemisia lancea against Haemonchus contortus and demonstrated greater antiparasitic activity in the essential oil substance set than the two isolated components when tested alone.…”
Section: Resultsmentioning
confidence: 99%
“…Plant extracts can be more effective than isolated compounds because the constituents of the extracts can act synergistically based on the following mechanisms: (a) pharmacokinetic or physicochemical effects that increase the solubility and bioavailability of substances, (b) antagonism to resistance mechanisms, and (c) elimination or neutralization of the adverse effects of one substance by another in the same extract. In summary, the sum of the effects of a mixture of substances can be greater than the individual effects of the substances (Amparo et al., 2019; Caesar & Cach, 2019; Carmona & Pereira, 2013). Components of plant extracts can act combined with conventional medicines, enhancing the therapeutic effects against certain diseases (Carmona & Pereira, 2013).…”
Section: Introductionmentioning
confidence: 99%