Herbal medicines used to treat diabetes in Southern regions of Pakistan and their pharmacological evidence

Tariq, Akash; Sadia, Sehrish; Yang, Fan; Ali, Shandana; Amber, Rahila; Mussarat, Sakina; Ahmad, Mushtaq; Murad, Waheed; Zafar, Muhammad; Adnan, Muhammad

doi:10.1016/j.hermed.2019.100323

Cited by 17 publications

(7 citation statements)

References 24 publications

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“…Medicinal plants remain of importance as main healthcare for approximately 85% of the world's population (Fitzgerald et al 2019;Rasethe et al 2019,). The World Health Organization (WHO) estimated that 65-80% of people from emerging countries depend on natural medications (Tariq et al 2020). About 25% of all synthetic drugs are still based on plant compounds (Bauer and Brönstrup 2014), and plants can supply low-cost medicinal care to developing countries (Djordjevic 2017;Sharif et al 2018), as well as developed nations.…”

Section: Introductionmentioning

confidence: 99%

Quantitative study on medicinal plants traded in selected herbal markets of Khyber Pakhtunkhwa, Pakistan

Shah¹,

Khan²,

Sulaiman³

et al. 2020

Ethnobot. Res. App.

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Background: This study is the first large-scale medicinal plant survey in the herbal markets of seven Districts of Khyber Pakhtunkhwa, Pakistan. The study provides the first significant catalogue on medicinal plants trade, price patterns, routes and utilization.Methods: Based on semi structured questionnaires, interviews and group discussions with 210 informants (92.86% men and 7.14% women) and personal observations were conducted.Results: A total of 161 plant species and three species of fungi were documented. Among the plants with highest Use Value, Allium cepa were used as anthelmintic and carminative, Bergenia ciliata for bladder stones and Brassica campestris for dandruff and angina. The reported data were analyzed using various ethnobotanical indices such as Use Value (UV), Use Report (UR), Relative Frequency of Citation (RFC) and Cultural Importance Values (CIV). The most cited used plant part was seeds (22.90%), followed by fruits (19.88%), leaves (15.67%) and root (10.24%). The UV ranged from 0.18 (Seriphidium kurramnse) to 0.86 (Allium cepa, Bergenia ciliata, Brassica campestris, Carum carvi, Coriandurm sativum and Plantago major). RFC ranged from 0.976 (Allium cepa, Piper nigrum and Punica granatum) to 0.076 (Nymphaea alba and Seriphidium kurramnse). The highest mean Cultural Importance (mCI) value was recorded for Allium cepa (0.842) and lowest for Ferula assa-foetida, Terminalia chebula and Croton tiglium having each (0.083). Conclusions:The current research confirmed that Khyber Pakhtunkhwa province is an interesting area for traditional plant use that should be studied in more detail.

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Section: Introductionmentioning

confidence: 99%

Quantitative study on medicinal plants traded in selected herbal markets of Khyber Pakhtunkhwa, Pakistan

Shah¹,

Khan²,

Sulaiman³

et al. 2020

Ethnobot. Res. App.

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“…They can be affordable and easily available [1]. People from rural or far areas have more knowledge of traditional medicine with a great diversity of plants [12]. Different polyphenols derived from different plants have impact on metabolism of glucose in various ways which include stimulating the secretion of insulin from β-cells of pancreas, help to inhibit the carbohydrate breakdown, increase in the absorption of glucose in intestine, receptors activation of insulin.…”

Section: Traditional Medications Against Diabetesmentioning

confidence: 99%

“…These extracts are prepared by mixing sample into methanol, ethanol or water. These extraction methods influence the chemical composition of compounds of plants as well as their activity for clinical purposes [12]. The phenolic compounds present in plants are also identified as hydroxylated aromatic rings and these combine together to form different compounds [18].…”

Section: Herbal Treatmentsmentioning

confidence: 99%

Just Role of Anti Diabetic Plants as Traditional Medicines

MW¹,

Raza²,

M³

et al. 2021

austinjpharmacolther

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Diabetes is one of the serious metabolic disorders occurred due to the imbalance of glucose level because of damaged pancreatic β-cells and lower production of insulin in body. Type 1 Diabetes Mellitus (TD1) and Type 2 Diabetes Mellitus (TD2) are main types of diabetes. Major portion of the world is suffering from Type 2 diabetes mellitus. Drugs used for diabetes are insulin, biguanides, sulfonylurea and inhibitors for a-glucosidase. Traditional medicines are under trial to reduce diabetic complications with no/minimum side effects. Many antidiabetic plants are under potential research i.e. strawberry, jamun, mulberry, fenugreek, turmeric, black pepper, garlic, ginger, grapefruit, and cinnamon. All of these have antidiabetic potential. These plants have bioactive compounds present in minute amounts. These compounds act against inflammation, diabetes, bacteria, fungi, other microbial infections, and obesity. These plants have antioxidant potential as well. Through HPLC “High- Performance Liquid Chromatography” screening, the compounds identified were caffeic acid, isoquercetin, kaempferol and other flavonoids. These compounds showed hypoglycemic activity. They are responsible for the increased uptake of glucose by the adipose and muscle tissues due to the activation of specific receptors i.e. PPARa “Peroxisome Proliferatoractivated Receptors a” and PPARγ (Peroxisome Proliferator-Activated Receptor γ). These activate the enzymes like glutathione, glutathione-S-transferase and catalase. Glutathione peroxidase inhibits the a-amylase then a-glucosidase lower glucose level. Effect of phytochemicals present in antidiabetic plants were studied in vitro and in vivo in animal models by inducing diabetes in them by streptozotocin, alloxan and diet on diabetic patients. Types of phytochemical compounds and their composition vary due to environmental factors, extraction and separation techniques which can have effect on clinical analysis. Bioavailability of oral drugs was also studied synergistically with these plants. Synthetic drugs, if are used with these natural compounds, they have no harmful effect but increase effectiveness. These herbal medications are more preferable, safe to use and cost effective due to which it is easily affordable by people. This review report covers the impact of these plants on diabetes mellitus reported so far.

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“…The whole plant of Momordica charantia L. has been reported to have anti-diabetic functions [3][4][5][6][7], whereas bitter melon (also known as bitter gourds or balsam pears), i.e., the fruit of M. charantia L., are the most commonly consumed parts of the plant as food or herbal medicine. Therefore, we attempted to analyze the lesser-known effects of bitter melon on the…”

Section: Introductionmentioning

confidence: 99%

Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions

Chang¹,

Cheng²,

Nurlatifah³

et al. 2021

Int. J. Med. Sci.

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The intestines have been recognized as important tissues for metabolic regulation, including glycemic control, but their vital role in promoting the anti-diabetic effects of bitter melon, the fruit of Momordica charantia L, has seldom been characterized, nor acknowledged. Evidence suggests that bitter melon constituents can have substantial interactions with the intestinal epithelial cells before circulating to other tissues. We therefore characterized the effects of bitter melon extract (BME) on intestinal epithelial cells. BME was found to contain substantial amounts of carbohydrates, proteins, and triterpenoids. TNF-α induced insulin resistance in an enterocyte cell line of IEC-18 cells, and BME promoted glucose utilization of the insulin-resistant cells. Further analysis suggested that the increased glucose consumption was a result of the combined effects of insulin sensitizing and insulin substitution functions of BME. The functions of insulin substitution were likely generated due to the activation of AMP-activated protein kinase. Meanwhile, BME acted as a glucagon-like peptide 1 (GLP-1) secretagogue on enteroendocrine cells, which may be mediated by the activation of bitter-taste receptors. Therefore, BME possesses insulin sensitizing, insulin substitution, and GLP-1 secretagogue functions upon intestinal cells. These effects of BME on intestinal cells likely play a significant part in the anti-diabetic action of bitter melon.

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Herbal medicines used to treat diabetes in Southern regions of Pakistan and their pharmacological evidence

Cited by 17 publications

References 24 publications

Quantitative study on medicinal plants traded in selected herbal markets of Khyber Pakhtunkhwa, Pakistan

Quantitative study on medicinal plants traded in selected herbal markets of Khyber Pakhtunkhwa, Pakistan

Just Role of Anti Diabetic Plants as Traditional Medicines

Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions

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