Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials

Chiarioni, Giuseppe; Popa, Stefan Lucian; Ismaiel, Abdulrahman; Pop, Cristina; Dumitrascu, Dinu Iuliu; Brata, Vlad Dumitru; Duse, Traian Adrian; Incze, Victor; Surdea-Blaga, Teodora

doi:10.3390/nu15194216

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Irritable bowel syndrome (IBS) is a common condition that occurs in the GI tract, and despite the high prevalence of IBS, its exact cause is still not well understood and current treatment approaches often focus on alleviating symptoms [ 7 ]. However, emerging research has shed light on the potential of traditional herbal medicines, such as AMK, to address the multifaceted nature of IBS [ 8 ]. IBS is a complex condition with various underlying factors, such as stress, gut dysbiosis, visceral hypersensitivity, and altered gut motility, which contribute to the uncomfortable and sometimes debilitating symptoms experienced by individuals with IBS [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Choi,

Lee

et al. 2024

Nutrients

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(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na+ (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.

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Section: Introductionmentioning

confidence: 99%

Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Choi,

Lee

et al. 2024

Nutrients

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Reducing organizational inequalities associated with algorithmic controls

Li,

Xiang

2024

Discov Artif Intell

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Algorithmic technologies are widely applied in organizational decision-making today, which can improve resource allocation and decision-making coordination to facilitate the accuracy and efficiency of the decision-making process within and across organizations. However, algorithmic controls also introduce and amplify organizational inequalities—workers who are female, people of color and the marginalized population, and workers with low skills, a low level of education, or who have low technology literacy can be disadvantaged and discriminated against due to the lack of transparency, explainability, objectivity, and accountability in these algorithms. Through a systematic literature review, this study comprehensively compares three different types of controls in organizations: technical controls, bureaucratic controls, and algorithmic controls, which led to our understanding of the advantages and disadvantages associated with algorithmic controls. The literature on the organizational inequality related to the employment of algorithmic controls is then discussed and summarized. Finally, we explore the potential of trustworthy algorithmic controls and participatory development of algorithms to mitigate organizational inequalities associated with algorithmic controls. Our findings raise the awareness related to the potential corporate inequalities associated with algorithmic controls in organizations and endorse the development of future generations of hiring and employment algorithms through trustworthy and participatory approaches.

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Traditional Chinese medicine for functional gastrointestinal disorders and inflammatory bowel disease: narrative review of the evidence and potential mechanisms involving the brain-gut axis

Liu,

Luo,

et al. 2024

Front. Pharmacol.

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Functional gastrointestinal disorders (FGIDs) and inflammatory bowel disease (IBD) are common clinical disorders characterized by recurrent diarrhea and abdominal pain. Although their pathogenesis has not been fully clarified, disruptions in intestinal motility and immune function are widely accepted as contributing factors to both conditions, and the brain–gut axis plays a key role in these processes. Traditional Chinese Medicine (TCM) employs a holistic approach to treatment, considers spleen and stomach impairments and liver abnormality the main pathogenesis of these two diseases, and offers a unique therapeutic strategy that targets these interconnected pathways. Clinical evidence shows the great potential of TCM in treating FGIDs and IBD. This study presents a systematic description of the pathological mechanisms of FGIDs and IBD in the context of the brain–gut axis, discusses clinical and preclinical studies on TCM and acupuncture for the treatment of these diseases, and summarizes TCM targets and pathways for the treatment of FGIDs and IBD, integrating ancient wisdom with contemporary biomedical insights. The alleviating effects of TCM on FGID and IBD symptoms are mainly mediated through the modulation of intestinal immunity and inflammation, sensory transmission, neuroendocrine–immune network, and microbiota and their metabolism through brain–gut axis mechanisms. TCM may be a promising treatment option in controlling FGIDs and IBD; however, further high-quality research is required. This review provides a reference for an in-depth exploration of the interventional effects and mechanisms of TCM in FGIDs and IBD, underscoring TCM’s potential to recalibrate the dysregulated brain–gut axis in FGIDs and IBD.

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Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials

Cited by 3 publications

References 49 publications

Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Reducing organizational inequalities associated with algorithmic controls

Traditional Chinese medicine for functional gastrointestinal disorders and inflammatory bowel disease: narrative review of the evidence and potential mechanisms involving the brain-gut axis

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