Herbal Therapies and Diabetes Among Navajo Indians

McCabe, Melvina; Gohdes, Dorothy; Morgan, Frank; Eakin, Joanne; Sanders, Margaret; Schmitt, Cheryl

doi:10.2337/diacare.28.6.1534-a

Cited by 14 publications

(17 citation statements)

References 2 publications

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“…Accordingly, in this study, we found that herbal medicine was not the most popular form of CAM (20AE6%). Other studies determined that herbal medicine was the most commonly used CAM in children (Argaez-Lopez et al 2003, McCabe et al 2005, Moolasarn et al 2005, Tindle et al 2005, Samdup & Song 2006, Arıkan et al 2008). Fernandez et al (1998 reported that herbal tea was the most frequently used CAM formulation by paediatric oncology patients.…”

Section: Discussionmentioning

confidence: 99%

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Complementary and alternative medicine use in children with thalassaemia

Efe

Işler

Sarvan

et al. 2012

Journal of Clinical Nursing

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Section: Discussionmentioning

confidence: 99%

“…Other studies determined that herbal medicine was the most commonly used CAM in children (Argaez‐Lopez et al. 2003, McCabe et al. 2005, Moolasarn et al.…”

Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine use in children with thalassaemia

Efe

Işler

Sarvan

et al. 2012

Journal of Clinical Nursing

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“…communis berry has been used in a wide variety of traditional medicinal systems as an appetite suppressant, diuretic, anti-inflammatory agent and analgesic, as well for the treatment of wounds, kidney and stomach disorders. [6][7][8] Several previous studies have reported growth inhibitory activity for J. communis berries towards multiple bacterial species. [10][11][12] Pharmacognosy Journal, Vol 8, Issue 3, May-Jun, 2016…”

Section: Discussionmentioning

confidence: 99%

“…7 Native Americans used J.communis berries as an appetite suppressant and in the treatment of diabetes. 8 Indeed, hypoglycemic/anti-diabetic effects have been demonstrated in several laboratory studies. [2][3] Recent studies have reported strong antioxidant activity for J.communis berries.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

Fernández¹,

Cock²

2016

Phcogj

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Introduction: J. communis berry is a high antioxidant fruit which is used in several traditional medicinal systems to treat a variety of diseases including rheumatism, arthritis and gout.This study was undertaken to examine the inhibitory activity of J. communis berry extracts on the growth of several bacteria associated with autoimmune inflammatory disease, and to test their ability to block CaCo 2 and HeLa cancer cell proliferation. Methods: J. Communis solvent extracts were prepared using solvents of varying polarity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a panel of pathogenic bacteria associated with autoimmune inflammatory diseases. Their MIC values were determined to quantify and compare their efficacies. Inhibitory activity against CaCo 2 and HeLa human carcinoma cell lines was evaluated using an MTS colorimetric cell proliferation assay. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanol, water and ethyl acetate J. communis berry extracts displayed moderate to potent growth inhibitory activity against bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all bacteria tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 9 of the 13 bacterial strains (69%). The ethyl acetate extract displayed the greatest potency, with MIC values substantially below 2000 µg/mL for all bacteria which it inhibited. It was most effective at inhibiting the growth of P. mirabilis, P. vulgaris and S. aureus, each with MIC's ≤ 500 µg/mL. The

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“…[4] Juniper berries and leaves have long been used as medicine by many cultures including the Navajo people. [5] Western American tribes combined the leaves and berries of J. communis with Barberry is root bark in herbal tea. Native Americans also used juniper berries as a female contraceptive.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Bhardwaj¹

2018

IJGP

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Aim:The present investigations were focused on isolation, characterization and antimicrobial evaluation and molecular docking of phytocompounds from Juniperus communis. Materials and Methods: α-Cadinol together with several other phytocompounds such as α-pinene, β-pinene, decanal, and α-terpineol were isolated from leaves of J. communis L using Soxhlet extraction with petroleum ether, ethanol, methanol, and aqueous solvents and identified through gas chromatography-mass spectrometry were then evaluated for the antimicrobial potential against Bacillus subtilis and Escherichia coli under in vitro conditions at different concentrations, namely 20, 40, 80, 100, 200, and 300 ppm. Furthermore, molecular docking analysis of α-Cadinol was performed against common antibiotic drug target proteins, namely penicillin-binding protein 2X (PBP), DNA gyrase Subunit B and topoisomerase IV using AutoDock4 (version 4.2) with the Lamarckian genetic algorithm. Results: Among these, maximum growth inhibition was observed at 300 ppm. Docking studies proclaim that α-Cadinol, a current phytochemical of J. communis L., has the most elevated wellness (fitness) score and more specificity toward the PBP than other protein targets and the bioactivity might be a result of these compounds exhibited in leaf extracts.

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Herbal Therapies and Diabetes Among Navajo Indians

Abstract: D.G. has received consulting fees from the University of New Mexico for projects related to diabetes in the Navajo.

Cited by 14 publications

References 2 publications

Complementary and alternative medicine use in children with thalassaemia

Complementary and alternative medicine use in children with thalassaemia

The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity

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