Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial

Gágyor, Ildikó; Hummers, Eva; Schmiemann, Guido; Friede, Tim; Pfeiffer, Sebastian; Afshar, Kambiz; Bleidorn, Jutta

doi:10.1016/j.cmi.2021.05.032

Cited by 20 publications

(7 citation statements)

References 25 publications

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“…Finally, nine RCTs were eligible (Figure 1). [6][7][8][9][29][30][31][32][33] Four trials investigated analgesics, two herbal formulations and placebo respectively. One study addressed delayed antibiotic prescribing.…”

Section: Resultsmentioning

confidence: 99%

“…We assessed the bias as low risk in all domains for three studies [29][30][31] and as high risk in three trials 8,9,33 in up to two domains. The risk was unclear in up to three domains, mainly due to lacking information [6][7][8][9][29][30][31][32][33] (Supplement Figure 2).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Conflict of interest disclosures IG, GF, TF, EH, and MM were included in the studies with reference number 31 .…”

Section: Author Contributionsmentioning

confidence: 99%

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Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis

Kaussner¹,

Röver

Heinz

et al. 2022

Clinical Microbiology and Infection

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Section: Resultsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

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Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis

Kaussner¹,

Röver

Heinz

et al. 2022

Clinical Microbiology and Infection

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“…Outra alternativa à base de plantas é a uva ursi (UU), uma droga que tradicionalmente foi utilizada para tratamento de ITU não complicada, apesar de possuir aspectos relacionados à sua eficácia e segurança com evidência limitada. A sua utilidade em casos de ITU se baseia no fato de que alguns compostos da UU como hidroquinonas e taninos possuem efeitos antissépticos e antimicrobianos (GAGYOR et al, 2021). resulta em colonização da região por uropatógenos.…”

Section: Terapêutica Não Antibióticaunclassified

Novas evidências na abordagem terapêutica das infecções do trato urinário (ITUs) em mulheres

Silva¹,

Ferreira²,

Guirardelli³

et al. 2023

Braz. J. Hea. Rev.

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No mundo, as infecções do trato urinário (ITUs) acometem em torno de 150 milhões de pessoas a cada ano. Ademais, as ITUs representam uma importante causa de morbidade em aproximadamente 10 a 20% das mulheres com idade entre 25 e 80 anos, acometendo em uma proporção de 8 mulheres para cada homem. O presente estudo de revisão buscou avaliar novas evidências na abordagem terapêutica das ITUs em mulheres, documentadas por meio de estudos clínicos e randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos e testes controlados e aleatórios; artigos publicados no último ano; que possuíam texto completo disponível e que abordassem acerca da terapêutica das ITUs em mulheres. Ficou constatado que a fosfomicina figura como opção de tratamento antibiótico oral adicional para casos de ITU na população feminina. Além disso, a diminuição potencial do impacto ecológico que a fosfomicina pode exercer sobre casos de ITU MDR é alvo para novos estudos. Já em relação às terapias não antibióticas, o hipurato de metenamina, produtos do cranberry, como as proantocianidinas de cranberry, sozinho ou combinado com antibióticos, além da uva ursi (UU) e do estrogênio vaginal são terapêuticas que mostraram benefícios nos casos de ITU ou ITU recorrente, mas que continuam sendo alvo para estudos potenciais futuros.

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“…The results of this RCT might suggest the beneficial effect of NSAR in mild‐to‐moderate symptomatic UTIs; however, the application should be recommended carefully [28]. In addition phytotherapy, such as BNO 1045 [29] or Uva Ursi [30] has also been investigated in RCTs suggesting non‐antibiotic treatment efficacies of 83.5% and 63.6%, respectively. A retrospective database analysis has also shown that treatment of the acute phase of cystitis with BNO 1045 results in less recurrent UTI [31].…”

Section: Antibiotic Treatment Of An Acute Episode Of Rutimentioning

confidence: 99%

Management of uncomplicated recurrent urinary tract infections

2021

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To discuss optimal management of recurrent urinary tract infections (UTIs) in women. About every second woman experiences at least one UTI in her lifetime, of those 30% experience another UTI, and 3% further recurrences. Especially young healthy women without underlying anatomical deficiencies suffer from recurrent UTIs (rUTI), which are associated with significant morbidity and reduction in quality of life. MethodsThis is a narrative review, investigating publications dealing with recurrent UTI in women. Risk factors and options for management are discussed. ResultsThe increased susceptibility of women to rUTI is based on the female anatomy in addition to behavioural, genetic, and urological factors. However, why some women are more likely than others to develop and maintain rUTI remains to be clarified. Invasive characteristics of certain uropathogenic Escherichia coli that are able to form extra-and intracellular biofilms and may therefore cause delayed release of bacteria into the bladder, may play a role in this setting. Treatment recommendations for an acute episode of rUTI do not differ from those for isolated episodes. Given the nature of rUTI, different prophylactic approaches also play an important role. Women with rUTI should first be counselled to use nonantibiotic strategies including behavioural changes, anti-adhesive treatments, antiseptics, and immunomodulation, before antibiotic prophylaxis is considered. In addition to the traditional treatment and prophylactic therapies, new experimental strategies are emerging and show promising effects, such as faecal microbiota transfer (FMT), a treatment option that transfers microorganisms and metabolites of a healthy donor's faecal matter to patients using oral capsules, enemas, or endoscopy. Initial findings suggest that FMT might be a promising treatment approach to interrupt the cycle of rUTI. Furthermore, bacteriophages, infecting and replicating in bacteria, have been clinically trialled for UTIs. ConclusionDue to the limitation of available data, novel treatment options require further clinical research to objectify the potential in treating bacterial infections, particularly UTIs.

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Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial

Abstract: Herbal treatment with Uva Ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: A randomized controlled trial, Clinical Microbiology and Infection,

Cited by 20 publications

References 25 publications

Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis

Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis

Novas evidências na abordagem terapêutica das infecções do trato urinário (ITUs) em mulheres

Management of uncomplicated recurrent urinary tract infections

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