Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.)

The bioactive compounds of Artemisia annua have been used as feed supplements due to their pharmacological activities. Recently, they were also proven to be additives to improve fish performance. The present study is part of a comprehensive investigation to analyze the use of the alcoholic extract of A. annua (ae-Aa) as a nutritional supplement to support sustainable aquaculture. The present study analyzed the effect of short-term dietary supplementation on resistance and health condition of Nile tilapia (Oreochromis niloticus) to evaluate a strategy for using ae-Aa in fish feed. Therefore, juvenile fish from a commercial fish farm (200 fish, 30.43 ± 0.54g) were distributed in 10 tanks (400 L, 20 fish/tank) and fed either with a control diet (ae-Aa free) or a diet containing 0.5% of ae-Aa for 15 days. Subsequently, 10 fish per treatment (2 fish per tank) were used to obtain blood and liver samples. We observed that short-term feed supply with ae-Aa was relevant to improve overall fish condition and productive performance. The short-term ae-Aa supplementation affected the fish immune system by increasing the number of leukocytes (41%), the leukocyte respiratory activity (21%), and the serum concentration of lysozyme (24%). These effects did not interfere with blood cell counts or affect oxygen-carrying capacity. Although glucose and chloride levels remained stable, ae-Aa reduced cortisol levels (-27%). Additionally, ae-Aa short-term feed supply influenced the hepatic antioxidant system by increasing CAT (77%), GPx (69%), GST (45%), and GSH (56%) activity and decreasing hepatic levels of LPO (-38%) and DNA damage (-21%). Furthermore, the ae-Aa short-term supplementation caused an increase in the intestinal villus area and improved growth causing a 17% increase in body mass and 2% in body length. Therefore, we suggest that short-term ae-Aa supplementation may be relevant to enhance fish health conditions and productive performance.

show abstract

Effects of Dietary Vitamin C on the Growth Performance, Antioxidant Activity and Disease Resistance of Fish: A Review

Rahman,

Alam,

Flura

et al. 2023

ejtas

View full text Add to dashboard Cite

Vitamin C comprises a group of related water-soluble substances that are crucial to the physiology and health of aquatic animals. Most aquatic animals have a limited capacity to synthesize Vitamin C, thus obtaining Vitamin C predominantly from diets. Because of its ability to scavenge free radicals, act as an antioxidant, and reduce inflammation, vitamin C has become increasingly popular as an ingredient for aquatic feed in recent years. However, the amount of vitamin C that various aquatic organisms require differs substantially from one another. This updated review presents a general outline of the possible physiological function of vitamin C for farmed aquatic animals, with an emphasis on the information on growth, antioxidant status, immunity, disease prevention, and reproductive performance, as well as the synergistic effects of vitamin C with other micronutrients such as vitamin E, glucans, and metal elements during the past few years. In addition, the interaction between the gut microbiota of aquatic animals and the dietary vitamin C that they consume is something that has been looked into. When it comes to expanding the use of vitamin C in the aquaculture industry, having a solid understanding of the positive functions and mechanisms that vitamin C possesses is of the utmost significance.

show abstract

Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.)

Cited by 3 publications

References 46 publications

Benefits and applications of vitamin C in farmed aquatic animals: an updated review

Benefits and applications of vitamin C in farmed aquatic animals: an updated review

Short-term feed supplementation with alcoholic extract of Artemisia annua improves health conditions and productive performance of juvenile Nile tilapia (Oreochromis niloticus)

Effects of Dietary Vitamin C on the Growth Performance, Antioxidant Activity and Disease Resistance of Fish: A Review

Contact Info

Product

Resources

About