Herbal wound healing agents

Yadav, Saurav; Mishra, Abhay Prakash; Kumar, Shambhu; Negi, Abha; Asha, Asha; Maurya, Vineet Kumar

doi:10.1016/b978-0-12-820284-5.00007-1

Cited by 14 publications

(11 citation statements)

References 53 publications

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“…Cocoa derived from the plant Theobroma cacao L. (family Malvaceae) renders tremendous health benefits including cardioprotective [ 5 ], anti-cancer [ 6 ], anti-inflammatory [ 7 ], anti-diabetic [ 8 ], anti-obesity [ 9 ], and wound healing properties [ 10 ]. Further, it has been reported to reduce blood pressure [ 11 ], asthma complications [ 12 ], and improve cognitive function [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival

Patil

Khanal

et al. 2022

PLoS ONE

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Theobroma cacao L. is a commercially important food/beverage and is used as traditional medicine worldwide against a variety of ailments. In the present study, computational biology approaches were implemented to elucidate the possible role of cocoa in cancer therapy. Bioactives of cocoa were retrieved from the PubChem database and queried for targets involved in cancer pathogenesis using BindingDB (similarity index ≥0.7). Later, the protein-protein interactions network was investigated using STRING and compound-protein via Cytoscape. In addition, intermolecular interactions were investigated via molecular docking. Also, the stability of the representative complex Hirsutrin-epidermal growth factor receptor (EGFR) complex was explored using molecular dynamics simulations. Crude extract metabolite profile was carried out by LC-MS. Further, anti-oxidant and cytotoxicity studies were performed in Chinese hamster ovary (normal) and Ehrlich ascites carcinoma (cancer) cell lines. Herein, the gene set enrichment and network analysis revealed 34 bioactives in cocoa targeting 50 proteins regulating 21 pathways involved in cancer and oxidative stress in humans. EGFR scored the highest edge count amongst 50 targets modulating 21 key pathways. Hence, it was selected as a promising anticancer target in this study. Structural refinement of EGFR was performed via all-atom molecular dynamics simulations in explicit solvent. A complex EGFR-Hirsutrin showed the least binding energy (-7.2 kcal/mol) and conserved non-bonded contacts with binding pocket residues. A stable complex formation of EGFR-Hirsutrin was observed during 100 ns MD simulation. In vitro studies corroborated antioxidant activity for cocoa extract and showed a significantly higher cytotoxic effect on cancer cells compared to normal cells. Our study virtually predicts anti-cancer activity for cocoa affected by hirsutrin inhibiting EGFR. Further wet-lab studies are needed to establish cocoa extract against cancer and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival

Patil

Khanal

et al. 2022

PLoS ONE

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“…In the same context, it has been proven that flavonoids play an important role in the wound healing process. Furthermore, phenolic acids, such as caffeic acid, promote fibroblast levels, leading to remolding injured tissue [ 17 , 20 ]. It has been proven that quercetin performs a crucial action on the collagen matrices for dermal wound healing processes [ 64 ], and the effectiveness of ferulic acid in the healing process was also proved [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…Plants with therapeutic effects have been relied on since ancient times to treat many diseases, and plants were recognized as an indispensable source of natural compounds such as triterpenes, flavonoids, phytosterols, and polyphenols [ 14 , 15 , 16 ]. Medicinal plants and their bioactive compounds, especially phenolic acids and flavonoids, are widely reported to cure wounds and ameliorate the healing process by interfering with cyclooxygenase and prostaglandin biosynthesis [ 17 , 18 , 19 , 20 ]. Many studies have proved the analgesic and the anti-inflammatory potential of several medicinal plants [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

et al. 2022

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Burns constitute a major challenge in medical science, and plants can be part of the solution. Dittrichia viscosa L. (Asteraceae) and Marrubium vulgare L. (Lamiaceae) are widely used in Moroccan traditional medicine to treat several diseases and possess high potency to cure wounds. This study aimed to investigate in vivo the analgesic, anti-inflammatory, and burn-healing effects of both plants and their mixture. The hydro-ethanolic extract of both plants was analyzed using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Burns were conducted on dorsal part of rats, and the wound healing process was evaluated during 21 days. Gallic acid, caffeic acid, ferulic acid, and quercetin were identified in M. vulgare extract. The analysis recorded the presence of caffeic acid, rosmarinic acid, rutin, and quercetin in D. viscosa. The group treated with the mixture showed the lowest abdominal contractions (30.4 ± 7.52) with the highest percentage of inhibition (69.12 ± 7.04%). The inhibition of paw inflammation for M. vulgare was 47.65%, followed by D. viscosa (33.86%) and the mixture (30.41%). The mixture showed the highest wound contraction at day 7 (33.16 ± 14.33%) and day 14 (87.54 ± 3.98%). D. viscosa showed the highest wound contraction on the 21st day (99.28 ± 0.44%). In conclusion, both plants and their combination showed promising results for burn healing.

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“…Medicinal plants are in a continuous process of exploration, resulting in the unearthing of novel plant-based pharmaceuticals to understand the molecular mechanisms of conventional medication and its active ingredients, which may help the renovation of plant-derived medications and detection of novel phyto-agents [63]. Phytomedicine may include several issues such as using medicinal plants as wound healing agents [64,65], natural anti-microbials from plants [66], herbal therapy or remedies [67], herbal cosmeticology [68], phytopharmaceuticals [69,70], phyto-pharmacology [71] using the herbal bioactivities in drug delivery systems like the ocular [72], pulmonary [73], transdermal [74], and vaginal and rectal drug delivery systems [75]. Therefore, it is very important to know exactly what we eat to stay healthy for a long time as conveyed by the term "nutraceuticals" [76].…”

Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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The Kingdom of Plantae is considered the main source of human food, and includes several edible and medicinal plants, whereas mushrooms belong to the Kingdom of fungi. There are a lot of similar characteristics between mushrooms and higher plants, but there are also many differences among them, especially from the human health point of view. The absences of both chlorophyll content and the ability to form their own food are the main differences between mushrooms and higher plants. The main similar attributes found in both mushrooms and higher plants are represented in their nutritional and medicinal activities. The findings of this review have a number of practical implications. A lot of applications in different fields could be found also for both mushrooms and higher plants, especially in the bioenergy, biorefinery, soil restoration, and pharmaceutical fields, but this study is the first report on a comparative photographic review between them. An implication of the most important findings in this review is that both mushrooms and plants should be taken into account when integrated food and energy are needed. These findings will be of broad use to the scientific and biomedical communities. Further investigation and experimentation into the integration and production of food crops and mushrooms are strongly recommended under different environmental conditions, particularly climate change.

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Herbal wound healing agents

Cited by 14 publications

References 53 publications

Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival

Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

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