Herbicidal activity of phosphonic, phosphinic, and phosphonous acid analogues of phenylglycine and phenylalanine

Solvent‐ and catalyst‐free reaction of (aminomethyl)phosphonates with epoxides: Synthesis of novel {[(2‐hydroxyethyl)amino]methyl}phosphonates

“…The synthesis of α-substituted phosphoryl derivatives (phosphonic and phosphinic acids) has attracted significant attention because of their biological activities, with broad application as enzyme inhibitors, antimetabolites, and antibiotics [15]. Among α-functionalized phosphonic acids, (aminomethyl)phosphonic acids have biological activities such as antibacterial, herbicidal, and fungicidal [16][17][18]. (Aminomethyl)phosphonic acids, the phosphonic acid analogues of 1-amino carboxylic acids, are an important class of compounds that exhibit a variety of interesting and useful properties.…”

Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase

“…In recent years, the synthesis of α-substituted phosphoryl derivatives (phosphonic and phosphinic acids) have attracted significant attentions, due to their biological activities with broad application as enzyme inhibitors, antimetabolites and antibiotics 2 . Among α-functionalized phosphonic acids, α-hydroxyphosphonic derivatives have potential biological activities such as anti-bacterial 4 , herbicidal 5 and fungicidal 6 . Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine (ACh) and is the most widely used target enzyme in studies with the purpose to synthesize new and more effective therapeutic agents to treat patients with diseases such as Alzheimer's disease (AD) or myasthenia gravis [7][8][9] .…”

A convenient and general procedure for the synthesis of α-ureidophosphonates under catalyst-free conditions

“…1 The synthesis of α-substituted phosphoryl derivatives (phosphonic and phosphinic acids) has attracted significant attention due to their biological activities with broad application as enzyme inhibitors, antimetabolites and antibiotics. 2 Among α-functionalized phosphonic acids, α-aminoalkylphosphonic derivatives have biological activities such as anti-bacterial, 3 herbicidal 4 and fungicidal. 5 Aminoalkylphosphonic acids, the phosphonic acid analogues of 1-amino carboxylic acids, are important class of compounds that exhibit a variety of interesting and useful properties.…”