2017
DOI: 10.1039/c6ra27883c
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Herbicide exposure induces apoptosis, inflammation, immune modulation and suppression of cell survival mechanism in murine model

Abstract: The lymphatic organ, the spleen, is of immense immunological importance as it is the largest blood filter in the mammalian system. The objective of the current study is to explore the detrimental cellular and subcellular effects in the spleen, mediated by the widely used herbicide, paraquat (PQ). PQ is an uncoupling agent for the electron transport chain complex in the mitochondria, which promulgates serious alterations in the intracellular oxidative microenvironment. This leads to the activation of a cascade … Show more

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Cited by 13 publications
(8 citation statements)
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“…Polyclonal antibodies were used for TNF-α and IL-6 (Imegenex, San Diego, CA, USA) and monoclonal for β-actin, GAPDH, LDH-A (Cell Signalling Technology, Danvers, MA, USA), BDNF (Abcam, Cambridge, United Kingdom). GAPDH was used as loading control 47,48 .…”
Section: Methodsmentioning
confidence: 99%
“…Polyclonal antibodies were used for TNF-α and IL-6 (Imegenex, San Diego, CA, USA) and monoclonal for β-actin, GAPDH, LDH-A (Cell Signalling Technology, Danvers, MA, USA), BDNF (Abcam, Cambridge, United Kingdom). GAPDH was used as loading control 47,48 .…”
Section: Methodsmentioning
confidence: 99%
“…The cells treated with control and CU-NPs exhibited cell cycle arrest to be 3.75± 0.94 % and 20.36±2.01 % in the sub-G1 phase, respectively. Thus, cell cycle arrest was significantly more in the NPs treated group than in the control group (p <0.05) [48][49][50].…”
mentioning
confidence: 90%
“…It was assumed that a single exposure to herbicide could induce oxidative stress. The significant increase in ROS levels and lipid peroxidation was found in mice injected intraperitoneally with paraquat at a sublethal dose [ 14 ]. Glyphosate-induced ROS accumulation has been reported to be associated with the oxidation and antioxidation system imbalance as well as lipid peroxidation [ 15 ].…”
Section: Introductionmentioning
confidence: 99%