1997
DOI: 10.1139/y97-149
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Herbicide-induced experimental variegate prophyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs

Abstract: Administration of oxadiazon or oxyfluorfen (1000 ppm in the diet) to male BALB/c mice for 9 days resulted in experimental porphyria, resembling the acute phase of human variegate porphyria. Urinary concentrations of 5-aminolevulinic acid and porphobilinogen reached 1500 and 3000 mumol/L, respectively. Both herbicides caused a decrease of protoporphyrinogen oxidase activity in liver and kidney. Brain protoporphyrinogen oxidase activity was not altered. Liver and kidney porphyrin content increased to 11 and 17 n… Show more

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Cited by 17 publications
(10 citation statements)
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“…The model is based on administration of the peroxidizing herbicide oxadiazon, a potent inhibitor of hepatic and renal protoporphyrinogen oxidase (Krijt et al 1997). The porphyrin excretion pattern in oxadiazontreated rodents, i.e.…”
Section: Discussionmentioning
confidence: 99%
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“…The model is based on administration of the peroxidizing herbicide oxadiazon, a potent inhibitor of hepatic and renal protoporphyrinogen oxidase (Krijt et al 1997). The porphyrin excretion pattern in oxadiazontreated rodents, i.e.…”
Section: Discussionmentioning
confidence: 99%
“…After extraction the samples were centrifuged, a part of the supernatant was diluted with methanol (1:20) and the porphyrin content was measured on a Perkin Elmer 203 spectrofluorimeter. Tissue porphyrin profiles were determined after solid phase extraction (Krijt et al 1997) of the porphyrin methyl esters by isocratic (n-heptane: ethylacetate: methanol, 60:40:2) high performance liquid chromatography on a 5 mm LiChrosorb NH2 column (150¿3.3 mm, Merck, Germany) with fluorescence detection (Shimadzu RF 530, 405 and 635 nm). Liver cytochrome P450 content, ethoxyresorufin-O-dealkylase and pentoxyresorufin-O-dealkylase were determined according to Rutten et al (1992), coumarin hydroxylase according to Aitio (1978).…”
Section: Methodsmentioning
confidence: 99%
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“…In addition, the ferric ferricyanide reduction reaction was carried out to detect PCT-speci®c cytoplasmic inclusions. 18 Total porphyrins were determined¯uorimetrically by methanol/sulphuric acid extraction and esteri®ca-tion, 9 porphyrin methyl esters were separated by isocratic HPLC. 9 Liver ethoxyresoru®n-O-dealkylase and methoxyresoru®n-O-demethylase were determined according to Rutten et al 19 on a Perkin Elmer 203 spectro¯uorimeter.…”
Section: Methodsmentioning
confidence: 99%
“…The interaction of porphyrins and metalloporphyrins with DNA has attracted considerable interest due to two main reasons. First, the two basic modes of porphyrin binding to DNA (intercalation and outside binding) can be used as models for the DNA binding of anti-cancer drugs [12][13][14][15]. Also, some porphyrins exhibit unique anti-viral and anti-bacterial activity [16][17][18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%