Herbicide Sulcotrione

Wu, Nanxiang

doi:10.5772/13284

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…One strategy that can be used in the search and development of new compounds to control weeds is the use of natural products. − This strategy has afforded compounds that can be used directly as herbicides. , In addition, natural products may serve as lead compounds (prototype bioactive molecules) that can be modified by either semisynthesis or synthesis to afford new active ingredients. , …”

Section: Introductionmentioning

confidence: 99%

Synthetic Analogues of the Natural Compound Cryphonectric Acid Interfere with Photosynthetic Machinery through Two Different Mechanisms

Teixeira

Pereira

Tomaz

et al. 2013

J. Agric. Food Chem.

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A series of isobenzofuran-1(3H)-ones (phthalides), analogues of the naturally occurring phytotoxin cryphonectric acid, were designed, synthesized, and fully characterized by NMR, IR, and MS analyses. Their synthesis was achieved via condensation, aromatization, and acetylation reactions. The measurement of the electron transport chain in spinach chloroplasts showed that several derivatives are capable of interfering with the photosynthetic apparatus. Few of them were found to inhibit the basal rate, but a significant inhibition was brought about only at concentrations exceeding 50 μM. Some other analogues acted as uncouplers or energy transfer inhibitors, with a remarkably higher effectiveness. Isobenzofuranone addition to the culture medium inhibited the growth of the cyanobacterium Synechococcus elongatus , with patterns consistent with the effects measured in vitro upon isolated chloroplasts. The most active derivatives, being able to completely suppress algal growth at 20 μM, may represent structures to be exploited for the design of new active ingredients for weed control.

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