It has long been claimed that native people were conservationists who had little or no impact on wildlife populations. More recently, though, it has been suggested that native people were keystone predators, who lacked any effective conservation strategies and instead routinely overexploited large mammal populations. To test these hypotheses, I performed a continuous-time analysis of wildlife observations made by Lewis and Clark because their journals are often cited as an example of how western North America teemed with wildlife before that area was despoiled by advancing European civilization. This included Bison, Elk, Mule Deer, Whitetailed Deer, Blacktailed Deer, Moose, Pronghorn Antelope, Bighorn Sheep, Grizzly Bears, Black Bears, and Grey Wolves. I also recorded all occasions on which Lewis and Clark met native peoples. Those data show a strong inverse relationship between native people and wildlife. The only places Lewis and Clark reported an abundance of game were in aboriginal buffer zones between tribes at war, but even there, wildlife populations were predator, not food-limited. Bison, Grizzly Bears, Bighorn Sheep, Mule Deer, and Grey Wolves were seldom seen except in aboriginal buffer zones. Moose were most susceptible to aboriginal hunting followed by Bison and then Elk, while Whitetailed Deer had a more effective escape strategy. If it had not been for aboriginal buffer zones, Lewis and Clark would have found little wildlife anywhere in the West. Moreover, prior to the 1780 smallpox and other earlier epidemics that decimated native populations in advance of European contact, there were more aboriginal people and even less wildlife. The patterns observed by Lewis and Clark are consistent with optimal foraging theory and other evolutionary ecology predictions.