Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase

“…The analogs described here (7,8,9,12,13, and 14) helped elucidate the biosynthetic route to hemiketal formation as well as confirmed the positive contributions of the C-4 hydroxy and epoxide groups for cytotoxic potency. Because compounds 2 and 3 are desirable drug leads, the dioxygenase mutant generated in this study sets the stage for further strain development.…”

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

“…Recently, three bacterial natural products, pladienolides [12–14], FR901464 [15–17], and herboxidiene [18, 19] (Figure 2), have all been shown to modulate the function of the spliceosome (Figure 1) [20–22]. Since pladienolide B and FR901464 are structurally distinct, and derived from distantly related bacterial genera ( Streptomyces and Pseudomonas , respectively), convergent evolution has led to divergent prokaryotes producing spliceosome modulators that share a common pharmacophore.…”

Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982

“…Herboxidiene (compound 1, Fig. 1A) was isolated from Streptomyces chromofuscus A7847 (ATCC 49982) as a novel polyketide which selectively and effectively controls several annual weed species (10,16). Later, compound 1 was found to effectively reduce plasma cholesterol and possess stronger low-density lipoprotein receptor upregulation activity than tricholstatin A and TMC-49A, representing a new type of anticholesterol molecule (13).…”