Herbs and their bioactive ingredients in cardio-protection: Underlying molecular mechanisms and evidences from clinical studies

Kumar, Gaurav; Dey, Sanjay Kumar; Kundu, Suman

doi:10.1016/j.phymed.2021.153753

Cited by 10 publications

(7 citation statements)

References 185 publications

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“…This is a new finding that JWXYS can prevent new-onset HF in hypertensive patients. CHM contains numerous active components or phytochemicals that may have multifaceted mechanisms of cardioprotective effects, including antioxidant, vasorelaxant, anti-inflammatory, anti-proliferative, or diuretic effects ( 29 ). Five frequently used single herbs, namely, Ge Gen, Huang Qi, Du Zhong, Huang Qin, and Chuan Xiong, were found to reduce the risk of HF in hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

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Chinese Herbal Medicine Reduces the Risk of Heart Failure in Hypertensive Patients: A Nationwide, Retrospective, Cohort Study

Liu

Hung

Hsu

et al. 2022

Front. Cardiovasc. Med.

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BackgroundHypertension (HTN) is the leading preventable risk factor for cardiovascular disease worldwide. Patients with HTN are at higher risk for heart failure (HF). The currently available therapeutic approaches for HTN do not always optimally control blood pressure or are not suitable for hypertensive patients who have a higher number of comorbidities. This study aimed to determine whether Chinese herbal medicine (CMH)-based interventions could reduce the risk of HF in hypertensive patients.MethodsThis retrospective study randomly selected 2 million enrollees from the National Health Insurance Research Database and identified 507,608 patients who were newly diagnosed with HTN in 2000–2017. After 1:1 frequency-matching by age, sex, index year, income, urbanization, duration of HTN, comorbidities and antihypertensive medications, we selected 8,912 eligible patients in each group. During 16 years of follow-up, 380 CHM users and 426 CHM non-users developed HF, representing incidence rates of 6.29 and 7.43 per 1,000 person-years, respectively.ResultsCHM users had significantly lower HF risk compared with CHM non-users (adjusted HR = 0.85, 95% CI 0.74–0.98). The markedly predominant effect was observed in those receiving CHM products for more than 180 days (adjusted HR = 0.65). The frequently prescribed formula, Jia-Wei-Xiao-Yao-San, and the single herbs Ge Gen, Huang Qi, Du Zhong, Huang Qin, and Chuan Xiong were significantly associated with lower risk of HF.ConclusionsThis population-based study revealed decreased HF risk in hypertensive patients with CHM use. These findings may provide a reference for HF prevention strategies and support the integration of CHM into clinical intervention programs that provide a favorable prognosis for hypertensive patients.

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Section: Discussionmentioning

confidence: 99%

“…Five frequently used single herbs, namely, Ge Gen, Huang Qi, Du Zhong, Huang Qin, and Chuan Xiong, were found to reduce the risk of HF in hypertensive patients. The possible mechanisms involved in preventing HF at least include inhibition of angiotensin converting enzyme or angiotensin II receptor (29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine Reduces the Risk of Heart Failure in Hypertensive Patients: A Nationwide, Retrospective, Cohort Study

Liu

Hung

Hsu

et al. 2022

Front. Cardiovasc. Med.

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“…Moreover, it increased the transcript level of MnSOD and GSS, the protein levels of B-cell lymphoma-2 (Bcl-2) and MnSOD, and the nuclear levels of Nrf-2 and FOXO3A (ALTamimi et al, 2021). Curcumin also lowered adenine-induced high blood pressure, urinary albumin, the inflammatory cytokines interleukins 1 (IL-1) and 6 (IL-6), tumor necrosis factor α (TNF-α), cystatin C (CST3), and adiponectin (ADIPOQ) (Kumar et al, 2021). In addition, it increased sclerostin levels in the blood and reduced oxidative stress in kidney homogenates (Ali et al, 2018).…”

Section: Diabetic Nephropathymentioning

confidence: 98%

“…Endothelial NO is an important vasodilator involved in various cardiovascular diseases (CVDs) and CKDs (Kumar et al, 2021). Renovascular hypertension is a leading cause of secondary hypertension, induced by atherosclerotic renovascular stenosis or fibromuscular dysplasia.…”

Section: Mitochondrial Dysfunction Mechanisms In Kidney Diseasesmentioning

confidence: 99%

Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction

Rahman

Akter²,

Dorotea

et al. 2022

Front. Pharmacol.

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Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have become critical clinical, socioeconomic, and public health concerns worldwide. The kidney requires a lot of energy, and mitochondria act as the central organelle for the proper functioning of the kidney. Mitochondrial dysfunction has been associated with the pathogenesis of AKI and CKD. Natural products and their structural analogs have been sought as an alternative therapeutic strategy despite the challenges in drug discovery. Many studies have shown that small-molecule natural products can improve renal function and ameliorate kidney disease progression. This review summarizes the nephroprotective effects of small-molecule natural products, such as berberine, betulinic acid, celastrol, curcumin, salidroside, polydatin, and resveratrol. Treatment with small-molecule natural products was shown to attenuate renal oxidative stress and mitochondrial DNA (mtDNA) damage and restore mitochondrial biogenesis and dynamics in the kidneys against various injury stimuli. Therefore, small-molecule natural products should be recognized as multi-target therapeutics and promising drugs to prevent kidney diseases, particularly those with mitochondrial dysfunction.

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“…At the same time, an increase in adiponectin, HDL, and lipoprotein lipase activity was observed [ 130 ]. Benefits of curcumin have also been found for the cardiovascular system, through inhibition of the JAK/STAT signaling pathway and the inhibition of atheroma plaque formation [ 131 ]. Another vascular effect of curcumin administration is to decrease pulse wave velocity [ 132 ].…”

Section: Potential Role Of Nutrition In Prevention Of Cardiovascular ...mentioning

confidence: 99%

Can Bioactive Food Substances Contribute to Cystic Fibrosis-Related Cardiovascular Disease Prevention?

Trandafir

Frăsinariu²,

Ţarcă³

et al. 2023

Nutrients

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Advances in cystic fibrosis (CF) care have significantly improved the quality of life and life expectancy of patients. Nutritional therapy based on a high-calorie, high-fat diet, antibiotics, as well as new therapies focused on CFTR modulators change the natural course of the disease. They do so by improving pulmonary function and growing BMI. However, the increased weight of such patients can lead to unwanted long-term cardiovascular effects. People with CF (pwCF) experience several cardiovascular risk factors. Such factors include a high-fat diet and increased dietary intake, altered lipid metabolism, a decrease in the level of fat-soluble antioxidants, heightened systemic inflammation, therapeutic interventions, and diabetes mellitus. PwCF must pay special attention to food and eating habits in order to maintain a nutritional status that is as close as possible to the proper physiological one. They also have to benefit from appropriate nutritional counseling, which is essential in the evolution and prognosis of the disease. Growing evidence collected in the last years shows that many bioactive food components, such as phytochemicals, polyunsaturated fatty acids, and antioxidants have favorable effects in the management of CF. An important positive effect is cardiovascular prevention. The possibility of preventing/reducing cardiovascular risk in CF patients enhances both quality of life and life expectancy in the long run.

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Herbs and their bioactive ingredients in cardio-protection: Underlying molecular mechanisms and evidences from clinical studies

Cited by 10 publications

References 185 publications

Chinese Herbal Medicine Reduces the Risk of Heart Failure in Hypertensive Patients: A Nationwide, Retrospective, Cohort Study

Chinese Herbal Medicine Reduces the Risk of Heart Failure in Hypertensive Patients: A Nationwide, Retrospective, Cohort Study

Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction

Can Bioactive Food Substances Contribute to Cystic Fibrosis-Related Cardiovascular Disease Prevention?

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