The application of zircon dating to the reconstruction of orogenic systems is invaluable since time constraints of the geological evolution of orogens are crucial for the proposal of geodynamic and paleogeographic models. Zircon is one of the most promising accessory minerals in geochronology of crystalline basements because of its high-closure temperature. Moreover, U-Pb data of relict and recrystallized grains indicate the maximum sedimentation age as well as the timing of metamorphism in metasediments. In addition, the U-Pb ages of magmatic zircons constrain the timescale of magmatism. The Calabria–Peloritani terrane (CPT) represents a key area in the Southern Variscan Belt, whose reconstruction is still unresolved. Therefore, a review of literature zircon age data accompanied with new data from six samples of orthogneisses, paragneisses, amphibolites, and actinolite schists, helps to constrain the evolution of this Cadomian fragment, affected by metamorphic and magmatic Variscan events. A revisiting of the timing of the geological events from Paleo-proterozoic to Permian is revealed by comparing the internal textures of zircons and their U-Pb age clusters. The detected age peaks at 2500 Ma, 1600 Ma, and 1000 Ma in the CPT were related to a provenance from West and East Gondwana realms. A sedimentation age around 630 Ma emerges for the middle-deep crust terranes of the CPT, affected by Ediacaran (579–540 Ma) intrusions, accompanied by metamorphism dated at 556–509 Ma in the host metasediments. In the following, during Ordovician–Silurian extensional tectonics, the former Cadomian terranes were at least locally affected by fluid-assisted metamorphism (around 450 Ma) whereas the upper extensional basins that formed, were infilled by sediments along with interspersed volcanic to subvolcanic products. All these pre-Silurian terranes were involved in the subduction process of the Palaeotethys–Gondwana margin beneath Laurussia. The compressive phase began around 347 Ma, with under-thrusting of the formerly Gondwana substrate that was subjected to middle-high grade metamorphism, while the Ordovician–Silurian sediments were scraped off along the front of the Southern Variscan Belt and affected by low-grade metamorphism. Decompression of the whole Variscan orogenic system started around 320 Ma, together with uplifting of the chain and emplacement of widespread granitic intrusions which ended around 280 Ma and completed the Variscan orogenic cycle in the CPT.