Let X be a class of left R-modules, Y be a class of right R-modules. In this paper, we introduce and study Gorenstein (X , Y)-flat modules as a common generalization of some known modules such as Gorenstein flat modules [9], Gorenstein n-flat modules [22], Gorenstein B-flat modules [7], Gorenstein AC-flat modules [2], Ω-Gorenstein flat modules [10] and so on. We show that the class of all Gorenstein (X , Y)-flat modules have a strong stability. In particular, when (X , Y) is a perfect (symmetric) duality pair, we give some functorial descriptions of Gorenstein (X , Y)-flat dimension, and construct a hereditary abelian model structure on R-Mod whose cofibrant objects are exactly the Gorenstein (X , Y)-flat modules. These results unify the corresponding results of the aforementioned modules.