Hereditary angioedema and thyroid autoimmunity.

Abstract

SUMMARY Sera from 91 patients with hereditary angioedema were screened for thyroid antibodies. The results for the 77 patients more than 17 years old were compared with previously published data for the prevalence of thyroid disease in a large community (Whickham). Of the female patients with hereditary angioedema, the prevalence of thyroglobulin antibodies (TGA) was 14-0%, higher than the expected 3% (p < 0 001). The prevalence of thyroid microsomal antibodies (TMA) was 20%, also higher than the expected 7-6% (p < 0-01). The age distributions of the females in both groups differed: in the group with hereditary angioedema there was a greater proportion of younger patients which should have resulted in a lower prevalence of thyroid antibodies. Adjusting for related patients with hereditary angioedema, there was still an increased prevalence of TGA (p < 0 01) and TMA (p < 0 01).

Chronic urticaria and thyroid autoimmunity markers

“…The level of TPO in our CU patients was considerably higher than that in the total population. The prevalence of thyroid antibodies that we and other investigators have detected in CU patients is similar [15][16][17][18][19]. Our study confi rms the apparent association between CU and thyroid autoimmunity.…”

“…The frequency of anti-thyroid peroxidase (TPO) or anti-thyroglobulin antibodies indicated by other authors is 12% to 33%. The TPOs are found more often [15][16][17][18][19]. O'Donnell at al.…”

Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

“…did not find higher CU severity levels in the presence of ATD, 26 which was in agreement with Feibelmann et al 15 Other studies have reported high prevalence of ATD in patients with hereditary angioedema 30 and improvement of isolated angioedema in patients treated with thyroxin, thus suggesting that there may be an association between ATD and angioedema. 31 Nonetheless, neither of these studies included any CIU cases, and therefore they cannot be properly compared with ours.…”

Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency

“…17,28,29 On the other hand, we cannot rule out the possibility that high anti-TPO level might predict the future development of an autoimmune disorder. 16 In patients with C1-INH-HAE, above-median FT 4 and FT 3 levels were associated with a reduced number of edematous episodes. Our study found above-median C1-INH f activity in a greater proportion of patients with above-median FT 4 levels.…”

“…12e15 Only a few publications provide data on the association between C1-INH-HAE and thyroid hormone (TH) levels. 16,17 These articles focus on immunoregulatory disorders (including thyroiditis) or patients with hypothyroidism or hyperthyroidism. Through the activation of the classic pathway of the complement system, C1-INH deficiency may predispose patients to the onset of autoimmune disorders, and these disorders may worsen the symptoms of C1-INH-HAE.…”