Hereditary determinants of gynecological cancer and recommendations

Carvalho, Jesus Paula; Carvalho, Filomena Marino; Chami, Anisse Marques; Filho, Agnaldo Lopes da Silva; Primo, Walquíria Quida Salles Pereira

doi:10.1055/s-0041-1736211

Rev Bras Ginecol Obstet

2021

DOI: 10.1055/s-0041-1736211

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Hereditary determinants of gynecological cancer and recommendations

Jesus Paula Carvalho

Filomena Marino Carvalho

Anisse Marques Chami

et al.

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2023

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The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Ran,

Xiao,

Tang

et al. 2023

Sci Rep

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Gynecological cancers are a leading cause of mortality for women, including ovarian cancer (OC), cervical squamous cell carcinoma (CESC), and uterine corpus endometrial carcinoma (UCEC). Nevertheless, these gynecological cancer types have not elucidated the role of cuproptosis and the correlated tumor microenvironment (TME) infiltration features. CRGs had important potential molecular functions and prognostic significance in gynecological cancers, especially in UCEC. Hub CRG, FDX1, was correlated with the CD8+ T cell immune infiltration in UCEC and CESC. FDX1 OE could significantly repress the proliferation ability in UCEC cells by MTT, EdU, and clone formation. High levels of FDX1 could repress ATP and lactic acid but enhance ROS and glucose levels by metabolism assay. The xenograft tumor model indicated that FDX1 OE significantly inhibited the growth of UCEC and attenuated the PCNA, HK2, PKM2, and Ki-67 expression. These CRGs are significant roles that could be potential markers and treatment targets to optimize the TME immune cell infiltration features for gynecological cancer types. FDX1 is a hub CRGs in UCEC to promote immune infiltration and attenuate proliferation and metabolism.

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The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Ran,

Xiao,

Tang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

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Hereditary determinants of gynecological cancer and recommendations

Cited by 1 publication

References 41 publications

The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

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