Hereditary neurological tumor syndromes: clues to glioma oncogenesis?

Chen, Zhongping; Yarosh, Daniel B.; Garcia, Yesenia; Tampieri, Donatella; Mohr, Gérard; Langleben, Adrian; Panasci, Lawrence C.

doi:10.3171/foc.1998.4.4.4

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…These findings indicated that the malignant phenotype of astrocytomas is at least partially regulated by β-catenin signaling and that the molecular mechanisms underlying the activation of astrocytes are closely related to the mechanisms of pathogenesis and the progression of growth of astrocytomas. Patients with Turcot syndrome highlight the involvement of β-catenin signaling in tumorigenesis within the CNS, where mutations of the APC gene, an important regulator of β-catenin signaling, cause the formation of brain tumors (29).…”

Section: Discussionmentioning

confidence: 99%

β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

Yang

Iyer²,

Yu³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Astrocytes are the most abundant cell of the CNS and demonstrate contact inhibition in which a nonproliferative, nonmotile cellular state is achieved once stable intercellular contacts are formed between mature cells. Cellular injury disrupts these intercellular contacts, causing a loss of contact inhibition and the rapid initiation of healing. Dysregulation of the molecular pathways involved in this process is thought to lead to an aggressive cellular state associated with neoplasia. We investigated whether a comparable correlation exists between the response of astrocytes to injury and the malignant phenotype of astrocytomas. We discovered that the loss of contact inhibition plays a critical role in the initiation and regulation of reactive astrocytes in the healing of wounds. In particular, injury of the astrocytes interrupts and destabilizes the cadherin-catenin complexes at the cell membrane leading to nuclear translocation of β-catenin and characteristic changes associated with the activation of astrocytes. Similar signaling pathways are found to be active—but dysregulated—in astrocytomas. Inhibition of β-catenin signaling diminished both the response of astrocytes to injury and induction of the malignant phenotype of astrocytomas. The findings shed light on a unique mechanism associated with the pathogenesis of astrocytomas and provide a model for the loss of contact inhibition that may broadly apply to understanding the mechanisms of tissue repair and tumorigenesis in the brain.

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Section: Discussionmentioning

confidence: 99%

β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

Yang

Iyer²,

Yu³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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“…Prior experience with submucosal tunneling [8] and peroral endoscopic myotomy (POEM) has suggested safety of such an approach [11, 12]. Access strategies for surgical interventions in the thoracic spine most commonly include thoracotomy, costovertebral, posterolateral, and transpedicular percutaneous approaches [13–16]. Open surgical techniques to expose the spine require the separation of musculoskeletal structures and traction of nerve roots to create an access large enough to accommodate surgical tools.…”

Section: Discussionmentioning

confidence: 99%

Natural Orifice Translumenal Endoscopic Surgery for Anterior Spinal Procedures

Magno

Khashab

Mas

et al. 2012

Minimally Invasive Surgery

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Background. NOTES techniques allow transesophageal access to the mediastinum. The aim of this study was to assess the feasibility of transesophageal biopsy of thoracic vertebrae. Methods. Nonsurvival experiments on four 50-kg porcine animals were performed. Transesophageal access to the mediastinum was attained using submucosal tunneling technique. Results. The posterior mediastinum was successfully accessed and navigated in all animals. Vertebral bodies and intervertebral spaces were easily approached while avoiding damage to adjacent vessels. Bone biopsy was successfully performed without complications, but the hardness of bone tissue resulted in small and fragmented samples. Conclusions. Peroral transesophageal access into the posterior mediastinum and thoracic vertebral bone biopsy was feasible and safe. The proximity of the esophagus to the vertebral column provides close and direct access to the thoracic spine and opens up new ground for the performance of multilevel anterior spine procedures using NOTES techniques.

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“…Neurofibromatosis type 1 (NF-1), von Hippel-Lindau disease, tuberous sclerosis, Li-Fraumeni and Turcot's neoplasia syndrome patients have an increased incidence of brain tumors, including brainstem neoplasms (Chen 1998;Albers & Gutmann 2009;Farrell & Plotkin 2009). Neurofibromatosis type 1 (NF-1), von Hippel-Lindau disease, tuberous sclerosis, Li-Fraumeni and Turcot's neoplasia syndrome patients have an increased incidence of brain tumors, including brainstem neoplasms (Chen 1998;Albers & Gutmann 2009;Farrell & Plotkin 2009).…”

Section: Etiologymentioning

confidence: 99%