2012
DOI: 10.1016/j.sder.2012.08.005
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Hereditary Nonmelanoma Skin Cancer

Abstract: Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer predisposition, such as basal cell nevus syndrome, xeroderma pigmentosum, epidermolysis bullosa, or oculocutaneous albinism. Different genes and signaling pathways have been shown to play a central ro… Show more

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Cited by 60 publications
(53 citation statements)
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“…those with cancer-predisposing syndromes (26,27). Recent studies suggest that genetic predisposition to reduced DNA repair capacity may be an underlying susceptibility factor for NMSC and other cancers (28)(29)(30)(31).…”
mentioning
confidence: 99%
“…those with cancer-predisposing syndromes (26,27). Recent studies suggest that genetic predisposition to reduced DNA repair capacity may be an underlying susceptibility factor for NMSC and other cancers (28)(29)(30)(31).…”
mentioning
confidence: 99%
“…Transporting proteins to the melanosome, stabilizing the melanosomal protein complex, and in regulating melanosomal pH are controlled by p protein. 7,8 Other types of OCA are OCA3, OCA4 and OCA5 which are not seen very commonly. Recently OCA5 was detected in members of a Pakistan family due to consanguinity.…”
Section: Discussionmentioning
confidence: 99%
“…Though SCC is the most common malignancy reported, [1] we saw a patient presenting with 3 lesions which were diagnosed as BCC of the nodular and keratotic types and BSCC, respectively [Case 2 - Figure 2a-d]. The patient underwent wide excision of all lesions with margin clearance but was lost to follow-up.…”
Section: Discussionmentioning
confidence: 99%
“…Commonly encountered neoplasms include SCC, BCC, rarely malignant melanoma which develops at a younger age when compared to patients of BCC without any predisposing genetic diseases. [1][2][3][4] …”
Section: Introductionmentioning
confidence: 99%