Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci

Brown, W. Mark; Lange, Ethan M.; Chen, H; Zheng, S. Lilly; Chang, Bao Li; Wiley, Katherine E.; Isaacs, Sarah D.; Walsh, Patrick C.; Isaacs, William B.; Xu, Jianfeng; Cooney, Kathleen A.

doi:10.1038/sj.bjc.6601417

Cited by 28 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, family members from prostate cancer pedigrees in the United States, Finland, and Sweden were genotyped. Later, the prostate cancer linkage at this region was confirmed by independent replication studies (Lange et al 1999;Xu et al 2003;Brown et al 2004;Gillanders et al 2004;Farnham et al 2005) and by the analysis of 104 German prostate cancer families (Bochum et al 2002).…”

mentioning

confidence: 52%

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

Kouprina¹,

Pavlı́ček²,

Noskov

et al. 2005

Genome Res.

View full text Add to dashboard Cite

Genetic linkage studies indicate that germline variations in a gene or genes on chromosome Xq27-28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer overlies a region of ∼750 kb containing five SPANX genes (SPANX-A1, -A2, -B, -C, and -D) encoding sperm proteins associated with the nucleus; their expression was also detected in a variety of cancers. SPANX genes are >95% identical and reside within large segmental duplications (SDs) with a high level of similarity, which confounds mutational analysis of this gene family by routine PCR methods. In this work, we applied transformation-associated recombination cloning (TAR) in yeast to characterize individual SPANX genes from prostate cancer patients showing linkage to Xq27-28 and unaffected controls. Analysis of genomic TAR clones revealed a dynamic nature of the replicated region of linkage. Both frequent gene deletion/duplication and homology-based sequence transfer events were identified within the region and were presumably caused by recombinational interactions between SDs harboring the SPANX genes. These interactions contribute to diversity of the SPANX coding regions in humans. We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster.

show abstract

mentioning

confidence: 52%

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

Kouprina¹,

Pavlı́ček²,

Noskov

et al. 2005

Genome Res.

View full text Add to dashboard Cite

show abstract

“…Prostate cancer loci on both arms of the X chromosome have been identiWed, including the HPCX locus at Xq27-28 (Bochum et al 2002;Brown et al 2004;Chang et al 2005;Cunningham et al 2003;Farnham et al 2005;Gillanders et al 2004;Gudmundsson et al 2008;Lange et al 1999;Schleutker et al 2000;Xu et al 1998). The »14 Mb linkage interval of HPCX was originally delineated within US, Swedish, and Finnish hereditary prostate cancer pedigrees (Xu et al 1998).…”

Section: Introductionmentioning

confidence: 97%

A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer

et al. 2008

View full text Add to dashboard Cite

We conducted an association study to identify risk variants for familial prostate cancer within the HPCX locus at Xq27 among Americans of Northern European descent. We investigated a total of 507 familial prostate cancer probands and 507 age-matched controls without a personal or family history of prostate cancer. The study population was subdivided into a set of training subjects to explore genetic variation of the locus potentially impacting risk of prostate cancer, and an independent set of test subjects to confirm the association and to assign significance, addressing multiple comparisons. We identified a 22.9 kb haplotype nominally associated with prostate cancer among training subjects (292 cases, 292 controls; chi(2) = 5.08, P = 0.020), that was confirmed among test subjects (215 cases, 215 controls; chi(2) = 3.73, P = 0.040). The haplotype predisposed to prostate cancer with an odds ratio of 3.41 (95% CI 1.04-11.17, P = 0.034) among test subjects. The haplotype extending from rs5907859 to rs1493189 is concordant with a prior study of the region within the Finnish founder population, and warrants further independent investigation.

show abstract

“…[16][17][18] Definitive evidence that this occurs in vivo has not yet been presented, although there are experiments suggesting that this might be the case. 19 …”

Section: A Protein Preamblementioning

confidence: 99%

The genetics of the amyloidoses: interactions with immunity and inflammation

Buxbaum

2006

Genes Immun

View full text Add to dashboard Cite

Historically, the amyloidoses have been associated with inflammation and the immune response. From Virchow's original description in human pathologic inflammatory states through their identification in horses used to produce antitoxin to their frequent occurrence in the course of multiple myeloma and a somewhat abortive designation as 'gammaloid', the disorders were felt to have an inflammatory origin. These presumptive associations antedated the availability of a reliable method for tissue extraction that would allow chemical analysis of the major deposited molecules. With the identification of the multiple precursors and the realization that most were not intrinsic elements of immune/inflammatory pathways, the investigative emphasis shifted to the analysis of the biophysical events involved in aggregation and fibril formation. As more in vivo models and better tools for examination of tissues have become available, it appears as if inflammation may participate as both a response to, and an amplifier of, the effects of the fibrillar aggregates. Hence, while only a limited number of amyloid protein precursors are involved in immunity and inflammation per se, host defense, in its broadest sense, is likely to be involved in the clinically relevant amyloidoses. Further it now appears that harnessing the immune respone in an appropriate fashion may be able to play a role in treatment.

show abstract

Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci

Cited by 28 publications

References 19 publications

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer

The genetics of the amyloidoses: interactions with immunity and inflammation

Contact Info

Product

Resources

About