Hereditary Punctate Palmoplantar Keratoderma (PPK) (Brauer‐Buschke‐Fischer Syndrome)

Gupta, Ritika; Mehta, Shilpa; Pandhi, Deepika; Singal, Archana

doi:10.1111/j.1346-8138.2004.tb00691.x

Cited by 27 publications

(29 citation statements)

References 11 publications

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“…We found that trachyonychia and twenty-nail dystrophy have been misdiagnosed in the literature in several cases [5,35,41,48,49,50,51,52](table 1). The diagnosis is often incorrectly based on the presence of dystrophic nail changes on all twenty nails, despite the fact that the nails do not show specific signs of trachyonychia.…”

Section: Resultsmentioning

confidence: 99%

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Jacobsen

Tosti

2016

Skin Appendage Disord

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Background/Aims: The term trachyonychia, also known as twenty-nail dystrophy, is used to describe thin, brittle nails with excessive longitudinal ridging. The term twenty-nail dystrophy has been incorrectly applied to other conditions that can affect all twenty nails. Therefore, we have conducted a comprehensive review of the clinical features of trachyonychia and have included a discussion regarding the diagnostic accuracy of this condition in the literature. Methods: In November and December 2015, we conducted a thorough literature search using the following search terms: ‘trachyonychia', ‘twenty nail dystrophy', and ‘sandpaper nails'. Articles that reported the epidemiology, disease associations, clinical presentation, histopathology, and treatment options for trachyonychia were included. Particular attention was given to case reports to identify misdiagnosed cases of twenty-nail dystrophy. Results: Our preliminary search yielded 184 results with 72 unique articles ultimately selected for review. Excluded articles included 27 articles in languages other than English, 18 commentaries or reviews, and 67 irrelevant articles. Twelve additional articles described nail abnormalities clinically different from trachyonychia. Conclusion: Many other conditions can cause widespread nail dystrophy. The specific characteristics of trachyonychia need to be considered to make the diagnosis of twenty-nail dystrophy.

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Section: Resultsmentioning

confidence: 99%

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Jacobsen

Tosti

2016

Skin Appendage Disord

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“…[5] Trachyonychia may present as an idiopathic disorder of the nails with no other cutaneous or systemic findings or it can be caused by a variety of other disorders. [2,10,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] It has been reported in association with several diseases such as vitiligo [32] and atopic dermatitis, [31] which are also seen in association with alopecia areata (AA). [10] It is the opinion of the reviewer that these cases most likely represent alopecia areata of the nails.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Alopecia areata [10] Atopic dermatitis [31] Autoimmune hemolytic anemia [18] Bart syndrome [19] Congential cutaneous candidiasis [19] Dyskeratosis congenita (Zinsser-Engman-Cole syndrome) [19] Graft-versus host disease [20] Hereditary punctuate palmoplantar keratoderma (Brauer-Buschke-Fischer syndrome) [19] Hidrotic ectodermal dysplasia (Clouston syndrome) [19] Ichthyosis vulgaris [21] Idiopathic thrombocytopenic purpura [18] Immunoglobulin A deficiency [22] Incontinentia pigmenti [23] Koilonychia [24] Lichen planus [25] Nail-Patella syndrome [19] Onychodysplasia of the index fingers [19] Pachyonychia congenita [19] Pemphigus vulgaris [26] Primary biliary cirrhosis [27] Psoriasis [28] Sarcoidosis [29] Trauma [30] Vitiligo [32] acanthosis, focal parakeratosis, and the accumulation of polymorphonuclear cells along the dorsal nail plate. [2] From a morphological point of view, patients who develop trachyonychia in the setting of psoriasis have more thickening of the nail plate as opposed to the thinning seen in lichen planus.…”

Section: Clinical Featuresmentioning

confidence: 99%

Trachyonychia: A comprehensive review

Gordon¹,

Vega²,

Tosti³

2011

Indian J Dermatol Venereol Leprol

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Trachyonychia or rough nails, may present as an idiopathic disorder of the nails or it can be associated with other dermatological conditions. The dystrophic nail findings seen in trachyonychia are characterized by brittle, thin nails, with excessive longitudinal ridging. The most common histopathologic features associated with trachyonychia are spongiosis and exocytosis of inflammatory cells into the nail epithelia; typical features of lichen planus or psoriasis can also be detected. Determining the cause of trachyonychia is challenging. Treatment is often unsatisfactory, although in general it should be aimed at the underlying cause, if found. In most cases, the nail abnormalities improve spontaneously.

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“…Клиническая карти-на характеризуется множественными участками ороговения желто-коричневого цвета, расположен-ными симметрично на коже ладоней, подошв и сги-бательной поверхности пальцев. Очаги поражения не сливаются между собой, потоотделение не нару-шено [27,28].…”

Section: клиническая дерматология и венерология 2 2015unclassified

Pathogenetic aspects underlying palmoplantar keratodermas. Current therapies

Круглова¹,

Жукова²,

Fineshina³

2015

Klin. dermatol. venerol.

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Ладонно-подошвенные кератодермии (ЛПК) (кератоз ладонно-подошвенный) составляют доста-точно гетерогенную группу болезней наследствен-ного или приобретенного характера, в клинической картине которых присутствуют диффузные или оча-говые утолщения рогового слоя эпидермиса пре-имущественно в области ладоней и подошв, реже в сочетании с кератозами другой локализации. Харак-терна эктодермальная дисплазия и воспаление [1][2][3]. Ладонно-подошвенные кератодермии представляют собой гетерогенную группу болезней наследственного или приобретенного характера, в клинической картине которых присутствуют диффузные или очаговые утолщения рогового слоя эпидермиса преимущественно в области ладоней и подошв, реже в сочетании с кератозами другой локализации. Для них характерны эктодермальная дисплазия и воспаление. В статье представлены общие сведения об эпидемиологии, этиологии и патогенезе данной патологии; дана классификация наследственных кератодермий, представлена связь генетических мутаций с проявлениями основных синдромов. Описаны клинические проявления кератодермий как приобретенного, так и наследственного характера. Авторы обращают внимание на то, что терапевтические мероприятия при кератодермиях чаще носят симптоматический характер. Для общего лечения всех форм кератодермий показано применение ретиноидов, предпринимаются попытки применения заместительной гормональной терапии. Наружное лечение кератодермий включает бальнеолечение, использование кератолитических и увлажняющих топических средств. В комплексе с наружной терапией с успехом применяются физиотерапевтические методы. Учитывая, что кератодермии в ряде случаев могут выступать симптомами паранеопластических процессов и других заболеваний, необходимо продолжить диагностический поиск и дифференцированный подход к терапевтическим мероприятиям. Ключевые слова: ладонно-подошвенные кератодермии, этиология, патогенез, клиника, лечение.Palmoplantar keratodermas are a heterogeneous group of diseases of the hereditary or acquired nature whose clinical picture includes diffuse or focal thickening of the horny layer of the epidermis, mainly in the palms and soles and sometimes in combination with keratoses in other areas. They are characterized by ectodermal dysplasia and inflammation. This article presents general information on the epidemiology, etiology, and pathogenesis of this disease, provides a classification of hereditary keratodermas, and shows the relationship between genetic mutations and manifestations of basic syndromes. The clinical manifestations of keratodermas of both acquired and hereditary nature are described. The authors point out at the fact that therapeutic procedures for keratodermas are usually aimed at treating symptoms. Application of retinoids is recommended for general treatment of all forms of keratoderma. Hormone replacement therapy is also used. Topical treatment of keratodermas includes balneotherapy and the use of keratolytic and moiorsturizing topical agents. Physiotherapy techniques are successfully used in combination with topical treatment. G...

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Hereditary Punctate Palmoplantar Keratoderma (PPK) (Brauer‐Buschke‐Fischer Syndrome)

Cited by 27 publications

References 11 publications

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Trachyonychia: A comprehensive review

Pathogenetic aspects underlying palmoplantar keratodermas. Current therapies

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