Hereditary structural defects in the descendants of mice exposed to roentgen ray irradiation

Nature of Renal Involvement in the Acro-Renal-Ocular Syndrome

“…Bagg and Little [7] and Bagg [8] reported congenital anomalies in the urinary system and the limbs in the offspring of irradiated mice. From these facts, it is not impossible to consider that anomalies in the present case were caused by an exogenous factor such as viral infection in the course of embryonic development.…”

On the Relationship between Maternal Conditions during Pregnancy and Congenital Malformations

“…In a survey of 4,446 children born to mothers with placenta praevia, Greenhill (1939) reported that the incidence of foetal abnormalities was approximately three times higher than under ordinary conditions. Before attaching importance to this disorder as a prinmary cause of congenital malformations, it is necessary to emphasize that according to Penrose (1939) Hanson (1923), Bagg and Little (1924), Murphy and Renyi (1930), Hertwig (1939), Raynaud and Friley (1943), and Warkany and Schraffenberger (1947). Two different methods have been employed.…”

Phenytoin Administration to Pregnant Mice: a Mutagenic Action?

“…The observed lesions resemble the abnor malities described in the offspring of X-ray treated mice [2,7], Comparable lesions have also been described in the br/br rabbits by Greene and Saxton [4], In this rabbit stock, it was reported that the primary defect is a blood abnormality, and that it is possible to prevent the amputations by several types of appropriate treatments administered to the pregnant females [16][17][18],…”