Hereditary Tremor in Ducks

Dyrendahl, S.

doi:10.1093/oxfordjournals.jhered.a106808

Cited by 5 publications

(3 citation statements)

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“…Segregation ratios of 1/8 and 1/4 give grossly aberrant results which cannot be explained by incomplete penetrance. Manifestation of the disease in terms of mean number of muscle contractions per second in affected Leghorn chicks was very similar to that observed by Dyrendahl (1958) in affected young of the common duck. Few segregating families of ducks were studied, but in these hereditary tremor appeared to be caused by only one pair of autosomal recessive genes (Dyrendahl, 1958).…”

Section: Analysis and Discussionsupporting

confidence: 73%

Penetrance of a rare genetic defect

Sittmann

1967

Genet. Res.

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Contrary to the conclusion of earlier workers, penetrance of a very rare genetic defect, congenital tremor in White Leghorn chicks, was found to be complete. By appropriate correction of the original data for small family size it is shown that the defect is determined not by one but two pairs of autosomal recessive genes. In the terminology of human genetics, ascertainment of affected individuals corresponded to conditions of ‘truncate’ selection in the case of maternal sibships and more nearly to ‘single’ selection in the case of paternal sibships.

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Section: Analysis and Discussionsupporting

confidence: 73%

Penetrance of a rare genetic defect

Sittmann

1967

Genet. Res.

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“…In our experiments, the prevention of testicular damage by cadmium through administration of large amounts of zinc salts was shown [Païizek, 1956]. Many authors have noted a high concentration of zinc compounds within the sperm cells and prostate, although its physiological significance is not yet clear [Bertrand & Vladesco, 1921;Mann, 1945;Mawson & Fischer, 1952, 1953Dyrendahl, 1954]. Recently, it was stated that the metabolic turnover of this metal is higher in the testis than in any other organ studied [Mawson, Fischer & Riedel, 1955].…”

Section: Discussionmentioning

confidence: 60%

The Destructive Effect of Cadmium Ion on Testicular Tissue and Its Prevention by Zinc

Parízek¹

1957

Journal of Endocrinology

358

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SUMMARY The subcutaneous administration of cadmium salts (cadmium chloride or lactate) to male rats and mice leads to acute destruction of the testes, with destruction of the seminiferous epithelium and interstitial tissue. These changes in turn evoke castration phenomena, but the atrophied accessory sex organs retain the ability to react to testosterone propionate. Within 20 days after the injection of cadmium, proliferation of fibroblasts in the interstitial spaces under the albuginea begins and is accompanied by an extensive formation of new blood vessels. Later, new Leydig cells appear; this is followed by a gradual return of the endocrine function of the testes. The spermatogenic epithelium of the seminiferous tubules, on the other hand, does not regenerate even 133 days after the injection of cadmium. The simultaneous administration of a large dose of zinc salts protects the testes completely against cadmium damage. The mechanism of interaction between these physico-chemically related metals and the theoretical and practical significance of these observations will be studied further.

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“…A few cases of mammary growth in non-pregnant cows following administration of iodinated casein have been reported [Dyrendahl, 1946;McQuillan, Trikojas, Camp¬ bell & Turner, 1948], but in one instance treatment with L-thyroxine during the first 6 months of pregnancy led to a depression in subsequent lactation [Hancock, Brumby & Turner, 1955]. The effect of thyroxine in the last experiment was not clear since subsequent lactational performance may not have been proportional to mammary gland growth.…”

Section: Resultsmentioning

confidence: 99%

THE GROWTH-STIMULATING EFFECT OF GROWTH HORMONE AND l-THYROXINE ON THE MAMMARY GLANDS AND UTERUS OF THE MOUSE

Flux¹

1957

Journal of Endocrinology

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Ovariectomized mice, treated with a preparation of growth hormone (GH) containing thyrotrophic hormone (TSH), showed increased mammary duct growth and increased uterine weight.The effect of the amount of GH used was similar in mice treated either with or without oestrone. Similar mice, treated with l-thyroxine, showed increased uterine weight but no significant effect on mammary duct growth.It appears that TSH may have been responsible for the effect of GH on uterine weight but not for its effect on mammary duct growth.Although growth hormone (GH) has been shown to be necessary for stimulation of growth of the mammary glands induced by steroid hormones in the rat [Lyons, Li, Cole & Johnson, 1953;Lyons, Li, Johnson & Cole, 1954], the effect of exogenous GH on steroid-induced mammary growth in animals with intact pituitaries does not appear to have been investigated.In the present study the effects of GH on oestrone-induced growth of the mammary duct systems and uteri of ovariectomized female mice were observed. Because the GH preparation used contained thyrotrophin as a contaminant, further experiments were carried out to establish the effect of hyperthyroidism in these mice. Organs other than the mammary glands and uteri were examined to provide information about the effectiveness of the dose-levels of hormones used and of the presence of other contaminants.

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Hereditary Tremor in Ducks

Cited by 5 publications

References 0 publications

Penetrance of a rare genetic defect

Penetrance of a rare genetic defect

The Destructive Effect of Cadmium Ion on Testicular Tissue and Its Prevention by Zinc

THE GROWTH-STIMULATING EFFECT OF GROWTH HORMONE AND l-THYROXINE ON THE MAMMARY GLANDS AND UTERUS OF THE MOUSE

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