Heredity of Low Back Pain in a Young Population: A Classical Twin Study

Hestbæk, Lise; Iachine, Ivan A.; Leboeuf‐Yde, Charlotte; Kyvik, Kirsten Ohm; Manniche, Claus

doi:10.1375/13690520460741408

Cited by 89 publications

(34 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there are no directly comparable studies in the literature on the role of heredity on LBP in such young age. Nevertheless, our results concur with results of Hestbaek et al [16] who demonstrated a minor genetic influence on the aetiology of LBP in adolescents aged 12-15. The genetic predisposition to health problems might vary considerably with age.…”

Section: Discussionsupporting

confidence: 93%

“…Genetic predisposition of LBP in adults has also been demonstrated by other studies [5,15,26]. Studying younger twins, Hestbaek et al [16] documented a considerable genetic contribution on lifetime prevalence LBP in those aged 15-41 years, but a similar genetic influence was not evident in twins aged 12-15 years. This finding suggests that genetic factors start to play a role in LBP only after middle adolescence, but age of onset of LBP was not evaluated in this large Danish study.…”

Section: Introductionmentioning

confidence: 66%

“…The genetic predisposition to health problems might vary considerably with age. This might be the case with LBP, as almost all twin studies conducted on adults have shown an important genetic influence on adulthood LBP [5,6,15,16,26], and that such influence shows a linear trend, especially in males, from age 16-18 till age 33-41 with an overall age-adjusted heritability estimate of 40% in females and 44% in males [16].…”

Section: Discussionmentioning

confidence: 95%

See 2 more Smart Citations

Genetic and environmental influences on non-specific low back pain in children: a twin study

et al. 2008

View full text Add to dashboard Cite

Aggregation of low back symptoms in families of children with low back pain (LBP) has been described. However, this may be due to genetic factors or common exposure to environmental factors. The aim of this study was to evaluate the relative contribution of genetic and environmental factors to childhood LBP by comparing the pairwise similarity of LBP in pairs of monozygotic (MZ) and dizygotic (DZ) twin children. Data was collected from 1995 to 1998 from a national sample of Finnish 11-year-old twins born between 1984 and 1987. This study sample constituted of 1,790 twin pairs: 610 MZ pairs, 598 same-sex DZ pairs, 582 opposite-sex DZ pairs. LBP pain was determined by using a validated pain questionnaire designed to assess musculoskeletal pains during the preceding 3 months. The outcome measure, LBP, was considered in three categories: none, once a month and at least once a week. Twin similarity in the report of LBP was quantified by correlations. Variance components for genetic and environmental factors were estimated by using biometric structural equation modelling techniques. The prevalence of LBP at least once a month was 15.7%, and at least once a week was 6.6%. The prevalence of frequent LBP in boys was significantly higher than that in girls (P = 0.04). In both genders, there were no differences in LBP reporting by zygosity (P [ 0.2). There were no statistically significant differences between polychoric correlations in male MZ and DZ pairs and between polychoric correlations in female MZ and DZ pairs, suggesting little genetic influence. Results obtained from the best-fitting genetic model suggests that, of the total variance in LBP, 41% (95% CI 34-48) could be attributed to shared environmental factors within families; and 59% (52-66) to unique (unshared) environmental factors. Our results suggest that genetic factors play, at most, a minor role in LBP in children; instead, symptoms seem to be related to a mixture of shared and unshared environmental factors. This study underscore the need for further highquality research, preferably prospective studies, to identify important modifiable risk factors in order to guide interventions that may prevent LBP in childhood.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Genetic and environmental influences on non-specific low back pain in children: a twin study

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The finding of this study displays that a (70%) hadn't family members with this disease, this for the study group while for control group; (83.3%) hadn't it yet. To support this study result, Hestbaeksuggested that there is a role of genetic influences on liability to LDP.Also, Beckstein disagrees with this study when concluded that the genetic factors of this disease appears to have a dominant role [23,24] . This study results show that (93.3%) of the study group having no disk surgery previously, and (100%) of the control group haven't it yet, too.…”

Section: Discussion Of the Clinical Characteristics Of The Study Sampmentioning

confidence: 72%

Effectiveness of an Instructional Program on Knowledge for Patients with Lumbar Disk Prolapse at Baghdad Teaching Hospitals

Hussein¹,

Atiyah²

2016

IOSR

View full text Add to dashboard Cite

show abstract

“…Details of all protocols are described below. Ethical approval for this study was granted by The institutional Human Research Committees of Curtin University and Edith Cowan University, and all participants gave written, informed consent structure, 21 and spinal range of motion. 2 From the lifestyle domain, activity levels 13 and time spent watching television 55 have been shown to be influenced by the family environment, and, psychologically, a strong link between family environment and offspring depressive and anxiety disorders has been demonstrated.…”

mentioning

confidence: 99%

An Exploration of the Relationship Between Back Muscle Endurance and Familial, Physical, Lifestyle, and Psychosocial Factors in Adolescents and Young Adults

Campbell

Briggs²,

O’Sullivan³

et al. 2011

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

Low back pain (LBP) is currently the most prevalent and costly musculoskeletal pain disorder, with increasing incidence throughout adolescence. 59 Adolescent LBP has also been linked to LBP in adulthood. 6 Therefore, clinical strategies have been investigated to prevent and rehabilitate LBP, including addressing back muscle endurance (BME). This previous research has identified that BME, as determined by the Beiring-Sorenson test, is predictive of LBP in specific populations, 3,31 and that reduced BME is a characteristic of some adult and adolescent populations with LBP. 1,23,37 Improving BME has, therefore, become a common focus for the prevention and rehabilitation of LBP in sporting groups, manual workers, and the general population, 42,44,50 with some evidence in sporting populations that BME improvements are associated with a reduced incidence of LBP. 44,50 However, there is little understanding of the association between factors (particularly, familial factors) believed to be predictive of BME performance in adolescents and young adults.A number of individual factors have been shown to be associated with BME. Body mass index (BMI) is frequently reported to be associated with BME in both adult 25,28,33,34 and adolescent 54 T T STUDY DESIGN: Cross-sectional investigation. T T OBJECTIVE:To explore the relationship between back muscle endurance (BME) and a range of familial, physical, lifestyle, and psychosocial variables in adolescents and young adults. T T BACKGROUND:There is evidence that low back pain interventions which focus on improved BME are effective. However, the mechanisms associated with BME performance in adolescents and young adults are largely unclear. In particular, the potential familial relationship between parents and their children remains unexplored. T T METHODS:This study utilized a subset of participants from the Joondalup Spinal Health Study cohort. One hundred nine children (47 boys, 62 girls) and 101 parents (39 fathers, 62 mothers) completed a series of physical, lifestyle, and psychosocial assessments. The univariable relationship between each covariate and BME was explored. Those found to have an association with child BME (P<.2) were included in an initial multivariable model and sequentially removed, until all remaining covariates were statistically significant (P<.05). T T RESULTS:Mothers' BME performance was related to children's performance, accounting for 14.4% of the variance in the children's BME. Fathers' BME performance had a similar, albeit nonsignificant effect. Children's sitting trunk angle, pain sensitivity, percent trunk fat, waist girth, and body mass index were associated with their BME performance, accounting for between 5.2% and 20.9% of BME. T T CONCLUSIONS:The final multivariable model, including mother's BME, percent trunk fat, and sitting trunk angle, explained 28% of the variance in BME performance, suggesting that for successful BME intervention a range of multidimensional variables should be considered.

show abstract

Heredity of Low Back Pain in a Young Population: A Classical Twin Study

Cited by 89 publications

References 23 publications

Genetic and environmental influences on non-specific low back pain in children: a twin study

Genetic and environmental influences on non-specific low back pain in children: a twin study

Effectiveness of an Instructional Program on Knowledge for Patients with Lumbar Disk Prolapse at Baghdad Teaching Hospitals

An Exploration of the Relationship Between Back Muscle Endurance and Familial, Physical, Lifestyle, and Psychosocial Factors in Adolescents and Young Adults

Contact Info

Product

Resources

About