Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo

Abstract

Background Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety. Hericium erinaceus mycelium has been widely investigated in both the in vivo studies and clinical trials for its neuroprotective functions because the mycelium contains hericenones and erinacines, which synthesize the nerve growth factor and brain-derived neurotrophic factor (BDNF). Recent in vivo reports have shown showed that erinacine A-enriched Hericium erinaceus mycelium can modulate BDNF/TrkB/PI3K/Akt/GSK-3β pathways to induce an antidepressant-like effect. A large body of evidence indicates that erinacine can pass the blood-brain barrier and suggests its neuroprotective function in both peripheral and central nervous systems. Thus, Hericium erinaceus mycelium may be a dual-function supplement for sleep disruption improvement while sustaining anxiolytic effects. Method To simulate the condition of sleep disruption, the mice were subjected to the tail suspension test (TST) for 15 min every day during the same period for nine consecutive days. Two different doses (75 and 150 mg/kg) of Hericium erinaceus mycelium were administered orally 20 min prior to the TSTs before entering the light period of 12:12 h L:D cycle. All sleep-wake recording was recorded for 24 h using electroencephalogram and electromyogram. The elevated-plus-maze and open-field tests were conducted to record the behavior activities. Results Consecutive TSTs prior to the light period could cause significant sleep disturbance and anxiety behavior in the elevated-plus-maze experiments. Results showed that administration with Hericium erinaceus mycelium at 150 mg/kg ameliorated the rodent anxiety (p < 0.05) and reversed the TST-induced NREM sleep disturbance in the dark period. Conclusion This is the first in vivo study suggesting that Hericium erinaceus mycelium has a dual potential role for anxiety relief through improving sleep disruptions.

Lion’s Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model

“…Additionally, mice given H. erinaceus traveled a greater distance in the center of the OFT compared to control mice. These results are consistent with studies using WT mice and the OFT to assess the effects of H. erinaceus [ 30 , 31 ]. These studies showed that mice consuming H. erinaceus spent more time in the center of the OFT.…”

“…This is an important finding, showing that H. erinaceus has anxiolytic effects in the rTg4510 tau mouse model. A recent study [ 30 ] also indicated that WT mice supplemented with H. erinaceus spent more time in the open arms of the EPM than control mice. Additionally, it has been shown that H. erinaceus significantly increased entries into the open arm and time spent in the open arm of the EPM in WT mice [ 41 ].…”

Therapeutic potential of Lion's Mane (Hericium erinaceus) in neurological and cognitive disorders - a review of the literature

“…Najnowsze badania skupiają się także na jego działaniu przeciwdepresyjnym 4 . Co więcej, stosowanie H. erinaceus w poprawie jakości życia pacjentów z neurodegeneracją jest uznawane za bezpieczne i skuteczne 5 .…”

Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging

“…Hericium erinaceus ( He ), also known as Lion’s mane and Monkey Head Mushroom [ 12 , 13 ] is an edible medicinal mushroom with many health properties [ 13 ], including antioxidant, anti-inflammatory, antisenescence, and nootropic effects in the Central Nervous System (CNS) [ 14 , 15 , 16 , 17 , 18 , 19 ]. Moreover, previous findings in mice demonstrated neuroprotective and anti-inflammatory action of H. erinaceus.…”