Areca nut has source of complex carbohydrates and natural fiber for humans. Almost all parts of this plant can be utilized. This plant is a commodity with high economic value in Indonesia. Moreover, the daily consumption of areca nut is passed down from generation to generation, a tradition is known as ‘chew Pinang’. The seeds of this plant are always present in the completeness of several traditional events in Indonesia. The development of this plant encountered challenges such as decreased productivity levels due to infection with pathogenic microorganisms. Pathogens that attack areca nut commodities can be in the form of bacteria and fungi. Leaf midrib rot is caused by the mycelia of the pathogenic fungus Athelia rolfsii, in addition to infection with Penicillium sp. during plant growth also results in losses. Phytophthora arecae, Micoplasm-like Organism (MLO), Ganoderma lucidu, Colletotrichum gloeosporioides, Curvularia sp., Pestalotia palmarum Cooke., Cephaleuros sp., Ganoderma lucidum, Fusarium sp., Rhizoctonia sp., Xanthomonas campestris, Ceralostomelia paradox.