Heritabilities of Lipids in Young European American and African American Twins

Iliadou, Anastasia; Snieder, Harold; Wang, Xiaoling; Treiber, Frank A.; Davis, Catherine L.

doi:10.1375/183242705774310187

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…Beekman et al (2002) found heritability estimates in a younger twin sample (aged 13−22) were higher (71%−82%) than in an adult sample (aged 34−92, 48%−77%). Similarly high heritabilities (69%−75%) have been reported in a recent study of young European American twins (mean age 17.9 ± 3.2 years; Iliadou et al, 2005).…”

supporting

confidence: 80%

A Longitudinal Genetic Study of Plasma Lipids in Adolescent Twins

2007

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P lasma lipids such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol and triglyceride levels contribute to variation in the risk of cardiovascular disease. The early stages of atherosclerosis in childhood have also been associated with changes in triglycerides, LDL and HDL. Heritability estimates for lipids and lipoproteins for adolescents are in the range .71 to .82, but little is known about changes of genetic and environmental influences over time in adolescence. We have investigated the contribution of genetic and environmental influences to variation in lipids in adolescent twins and their nontwin siblings using longitudinal twin and family data. Plasma HDL and LDL cholesterol, total cholesterol and triglycerides data from 965 twin pairs at 12, 14 and 16 years of age and their siblings have been analyzed.

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supporting

confidence: 80%

A Longitudinal Genetic Study of Plasma Lipids in Adolescent Twins

2007

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“…Beekman et al (2002) found that heritability estimates in a younger twin sample (aged 13−22) were higher (71%−82%) than in an adult sample (aged 34−92, 48%−77%). Similarly high heritabilities (69%−75%) have been reported in a recent study of young European American twins (mean age 17.9 ± 3.2 years) (Iliadou, Snieder et al, 2005). These findings suggest that lipid levels in adolescence are strongly influenced by genetic factors.…”

supporting

confidence: 83%

Linkage and Association Analyses of Longitudinally Measured Lipid Phenotypes in Adolescence

Middelberg

Gordon²,

Zhu³

et al. 2008

Twin Res Hum Genet

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The genetic basis of cardiovascular disease (CVD) is complex and still largely elusive. Plasma lipid concentrations are well-established risk factors for cardiovascular disease (CVD), and have adult heritabilities ranging from 0.48 to 0.87. Estimates for adolescents are slightly higher (range 0.71 to 0.82). To identify loci affecting lipid concentrations across adolescence, we analyzed longitudinal lipid data in a sample of 134 monozygotic and 626 dizygotic twin pairs at ages twelve, fourteen and sixteen, and their siblings, from 760 Australian families. Univariate linkage analysis for each phenotype and time point was supplemented by multivariate analysis across the time points. A genome-wide association scan was also performed on a subset of the subjects (N= 441). The strongest linkage was seen for triglycerides on chromosome 6p24.3 (multivariate –log10p= 6.81; equivalent LOD = 6.13;p= 1.55 × 10–7). Significant linkage was also found for LDL cholesterol on chromosome 2q35 (multivariate –log10p= 5.59; equivalent LOD = 4.53;p= 2.57 × 10–6). In the association analysis, rs10503840 on 8p21.1 was significantly associated with total cholesterol levels at age fourteen (p= 8.24 × 10–7, estimated significance threshold 2.45 × 10–6). Association atp< 2.25 × 10–6was also found between triglycerides at age 12 and rs10507266, in an intron ofTHRAP2(MIM 608771) on 12q24.21; and between HDL-C at age 14 and rs10506325 in an intergenic region of 12q13.13. Suggestive evidence of association at ages twelve and fourteen was found between HDL-C and rs10492859 on 16q23 (p= 2.42 × 10–5and 2.77 × 10–4, respectively). Further longitudinal genetic studies of cardiovascular risk factors, focused on critical periods of development or change, are needed.

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“…There was a high level of intra-pair agreement on contact frequency for the 4317 pairs in which both twins responded (rho = 0.81). The average level of contact frequency within the pair was used for (Fenger et al, 2007) e (Goode et al,2007) f (Henneman et al, 2008) g (Isaacs et al, 2007) h (McQueen et al, 2003) i (Snieder et al, 1999) j (Souren et al, 2007) k (VelasquezMelendez et al, 2007) l (Chien et al, 2007) m (Iliadou et al,2005) n (Hokanson et al, 2003) o (Beekman et al, 2002) p (Iliadou et al, 2001) q (Middelberg et al, 2002) r (Santos et al, 2006) s (Snieder et al, 2001) t (Simonis-Bik et al, 2008) u (Berrahmoune et al, 2007) v (Fox et al, 2008) w (Lange et al, 2006) x (Su et al, 2008) y (Wessel et al, 2007) z (Worns et al, 2006) https://www. these pairs.…”

Section: Twin Contact and Age At Separationmentioning

confidence: 99%

Genetic Dominance Influences Blood Biomarker Levels in a Sample of 12,000 Swedish Elderly Twins

et al. 2009

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In twin studies of cardiovascular disease biomarkers the dizygotic correlations are often estimated to be less than half of monozygotic correlations indicating a potential influence of nonadditive genetic factors. Using a large and homogenous sample, we estimated the additive and dominance genetic influences on levels of high density lipoprotein, low density lipoprotein, apolipoprotein A-I, apolipoprotein B, total cholesterol, triglycerides, glucose, hemoglobin Alc and c-reactive protein, all of which are biomarkers associated with cardiovascular disease. The blood biomarkers were measured on 12,000 Swedish twins born between 1911 and 1958. The large sample allowed us to obtain heritability estimates with considerable precision and provided adequate statistical power for estimation of dominance genetic components. Our study showed complete absence of the shared environment component for the investigated traits. Dominant genetic component was shown to be significant for low density lipoprotein (0.18), glucose (0.31), Hemoglobin Alc (0.55), and c-reactive protein (0.27). To our knowledge, this is the first statistically significant evidence for dominance genetic variance found for low density lipoprotein, glucose, hemoglobin Alc, and c-reactive protein in a population based twin sample. The study highlights the importance of acknowledging nonadditive genes underlying the risk of developing cardiovascular diseases.

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Heritabilities of Lipids in Young European American and African American Twins

Cited by 17 publications

References 24 publications

A Longitudinal Genetic Study of Plasma Lipids in Adolescent Twins

A Longitudinal Genetic Study of Plasma Lipids in Adolescent Twins

Linkage and Association Analyses of Longitudinally Measured Lipid Phenotypes in Adolescence

Genetic Dominance Influences Blood Biomarker Levels in a Sample of 12,000 Swedish Elderly Twins

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