Heritability and confirmation of genetic association studies for childhood asthma in twins

Ullemar, Vilhelmina; Magnusson, Patrik K. E.; Lundholm, Cecilia; Zettergren, Anna; Melén, Erik; Lichtenstein, Paul; Almqvist, Catarina

doi:10.1111/all.12783

Cited by 86 publications

(73 citation statements)

References 46 publications

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“…It is well known that a parental history of allergy is an important risk factor for asthma, allergic symptoms, and sensitization. 32,33 In this study, we found that parental asthma increased the risk of asthma in the children, while parental hay fever increased their risk of hay fever, cat allergy, and for paternal hay fever even dog allergy.…”

Section: Discussionsupporting

confidence: 47%

Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13

Al-Tamprouri

Barman

Hesselmar

et al. 2019

Immunity Inflam & Disease

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Background Avoidance of pets as a strategy for preventing atopic diseases has been questioned. This study aimed to identify the risk of sensitization and allergic symptoms at age 13 in relation to dog‐ and cat‐keeping during and after the first year of life. Methods The study included all children born at Östersund Hospital in Northern Sweden between February 1996 and January 1997 (n = 1231). At inclusion, parents were asked to answer questionnaires about lifestyle, including cat‐ and dog‐keeping. Dog allergy, cat allergy, hay fever, and asthma were diagnosed based on parental reported allergic symptoms at 13 years of age (n = 834). The risks of sensitization or allergy in relation to dog‐ and cat‐keeping during and after the first year of life were analyzed with logistic regression. To adjust for reverse causation, all subjects that had reported avoidance of pets due to allergic symptoms of the child or allergy in the family (n = 177) were excluded. Results Dog‐ or cat‐keeping during the first year of life reduced the risk of sensitization to dog or cat allergens, respectively, and to birch and to at least one of the 10 allergens tested. Cat‐keeping, both during and after the first year of life, reduced the risk of cat allergy and hay fever. Having a dog at home during the first year of life reduced the risk of dog and cat allergy, whereas dog‐keeping after the first year of life did not affect allergic symptoms. Conclusions Cat ownership, either during or after the first year of life, may be a strategy for preventing the development of cat allergy and hay fever later in life. Dog ownership reduced the risk of sensitization to dog and birch allergen, and also the risk of cat and dog allergy, but had no effect on hay fever.

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Section: Discussionsupporting

confidence: 47%

Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13

Al-Tamprouri

Barman

Hesselmar

et al. 2019

Immunity Inflam & Disease

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“…We have previously validated the register-based comparison variable "register-based ever asthma" against medical records with high positive predictive values (0.89 95% CI: 0.85-0.92) for clinical asthma diagnosis. 21 This definition of asthma has been applied in several studies as a proxy for ever/incident asthma [29][30][31][32][33] as well as for current/prevalent asthma. 30 Another study investigating "reported doctor's diagnosis" found a moderate PPV of 0.57 when the question of parental-reported doctor's diagnosis was validated against asthma medication reimbursement in a younger cohort.…”

Section: Discussionmentioning

confidence: 99%

Agreement between asthma questionnaire and health care register data

Hedman

Gong

Lundholm

et al. 2018

Pharmacoepidemiology and Drug

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“…A study in twins with childhood asthma showed that allergic diseases of childhood are highly heritable. 14 In this study, the authors found that the SNP rs3771180 in IL1RL1 is associated both with asthma and with AR. 14 Kurakula et al 15 found that the SNP rs4851765 in FHL2 shows an association with the severity of bronchial hyper-responsiveness, identifying FHL2 as a novel gene associated with asthma severity in humans.…”

mentioning

confidence: 67%

Recent developments and highlights in allergic rhinitis

Meng

Wang

Zhang

2019

Allergy

135

105

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Allergic rhinitis (AR) is a disease with high prevalence all over the world and therefore needs to be thoroughly investigated and treated accordingly. The mechanisms underlying the pathology and treatment of AR have been widely studied, but many aspects remain unclear and warrant further investigations. This review presents an overview of recently published papers highlighting the risk factors, mechanisms, and treatment of AR. Additionally, recent studies discussing the role of single nucleotide polymorphism, DNA methylation, regulatory B cells, group 2 innate lymphoid cells, immunotherapy, and biologics in AR are also covered. K E Y W O R D Sallergic rhinitis, biologics, epigenetics, risk factors, treatment | 2321 MENG Et al.

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Heritability and confirmation of genetic association studies for childhood asthma in twins

Abstract: Asthma and allergic diseases of childhood are highly heritable, and these high-risk genetic variants associated specifically with childhood asthma, except for one SNP shared with hay fever.

Cited by 86 publications

References 46 publications

Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13

Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13

Agreement between asthma questionnaire and health care register data

Recent developments and highlights in allergic rhinitis

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