Heritability and genetic correlations of obesity-related phenotypes among Roma people

Poveda, Alaitz; Ibáñez, Ma Eugenia; Rebato, Esther

doi:10.3109/03014460.2012.669794

Cited by 12 publications

(10 citation statements)

References 36 publications

(54 reference statements)

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“…Although already used for nearly a century, the extended pedigree design is still utilized to estimate the effect of genetic factors on BMI. This approach is useful when studying populations where twin data or large GWA studies are not available, such as the Spanish Roma people (Poveda et al, 2012) or the Omani Arabs (Bayoumi et al, 2007). Additionally, increasing the possibilities to link pedigree information with medical records allows for collecting very large datasets with modest costs, allowing not only the estimation of the heritability of BMI and other obesity indicators but also how much they share a genetic background with other traits (Polubriaginof et al, 2018).…”

Section: Extended Pedigree Studiesmentioning

confidence: 99%

Obesity and eating behavior from the perspective of twin and genetic research

Silventoinen

Konttinen

2020

Neuroscience & Biobehavioral Reviews

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Obesity has dramatically increased during the last decades and is currently one of the most serious global health problems. We present a hypothesis that obesity is a neuro-behavioral disease having a strong genetic background mediated largely by eating behavior and is sensitive to the macro-environment; we study this hypothesis from the perspective of genetic research. Genetic family and genome-wide-association studies have shown well that body mass index (BMI, kg/m 2) is a highly heritable and polygenic trait. New genetic variation of BMI emerges after early childhood. Candidate genes of BMI notably express in brain tissue, supporting that this new variation is related to behavior. Obesogenic environments at both childhood family and societal levels reinforce the genetic susceptibility to obesity. Genetic factors have a clear influence on macro-nutrient intake and appetiterelated eating behavior traits. Results on the gene-by-diet interactions in obesity are mixed, but emerging evidence suggests that eating behavior traits partly mediate the effect of genes on BMI. However, more rigorous prospective study designs controlling for measurement bias are still needed.

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Section: Extended Pedigree Studiesmentioning

confidence: 99%

Obesity and eating behavior from the perspective of twin and genetic research

Silventoinen

Konttinen

2020

Neuroscience & Biobehavioral Reviews

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“…Heritability estimates for visceral fat range from 40% to 90% . Monogenic syndromic, monogenic nonsyndromic, and polygenic forms of abdominal obesity have been reported in literature .…”

Section: Introductionmentioning

confidence: 99%

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

et al. 2018

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We conducted a hypothesis-free cross-trait analysis for waist-to-hip ratio adjusted for body mass index (WHR adjBMI ) loci derived through genome-wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHR adjBMI single-nucleotide polymorphisms (SNPs), and their proxy SNPs were identified. These SNPs were used to extract cross-trait associations between WHR adjBMI SNPs and other traits through the NHGRI-EBI GWAS Catalog. Pathway analysis was conducted for pleiotropic WHR adjBMI SNPs. We found 160 WHR adjBMI SNPs and 3675 proxy SNPs. Cross-trait analysis identified 239 associations, of which 100 were for obesity traits. The remaining 139 associations were filtered down to 101 unique linkage disequilibrium block associations, which were grouped into 13 categories: lipids, red blood cell traits, white blood cell counts, inflammatory markers and autoimmune diseases, type 2 diabetes-related traits, adiponectin, cancers, blood pressure, height, neuropsychiatric disorders, electrocardiography changes, urea measurement, and others. The highest number of cross-trait associations were found for triglycerides (n = 10), high-density lipoprotein cholesterol (n = 9), and reticulocyte counts (n = 8). Pathway analysis for WHR adjBMI pleiotropic SNPs found immune function pathways as the top canonical pathways. Results from our original methodology indicate a novel genetic association between WHR adjBMI and reticulocyte counts and highlight the pleiotropy between abdominal obesity, immune pathways, and other traits.

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“…The Roma, isolated and persecuted throughout history, are still forced to live on the margins of society, thus maintaining and developing their own identity. It can be assumed that the maintenance of a traditional way of life within closed communities together with a shift to a more sedentary lifestyle and unhealthy eating patterns (transition to a Westernized lifestyle according to Poveda et al (33) ) have been decisive in the increased health risk of this group in Italy. It is also likely that their worse access to health services is partially responsible for their poorer health in comparison to non-Roma (34) .…”

Section: Discussionmentioning

confidence: 99%

Anthropometric parameters in relation to glycaemic status and lipid profile in a multi-ethnic sample in Italy

Gualdi‐Russo

Zaccagni

Dallari³

et al. 2014

Public Health Nutr.

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Objective: To examine the health status of ethnic minorities in Italy. Furthermore, we aimed to assess the association between anthropometric and blood parameters connected with health status. Design: A cross-sectional study. Anthropometric data were collected by direct measurements and blood glucose, total cholesterol and TAG were analysed. Setting: Bologna, northern Italy. Subjects: A multi-ethnic sample of adult immigrants and Roma. Results: Significant correlations between anthropometric and blood parameters were found. Among the ethnic groups, Roma males had the highest values of glucose, total cholesterol and TAG. In the females the situation was more balanced among ethnic groups. Conclusions: The data from this survey indicate that poor health status is a very common problem among ethnic groups living in Italy, especially the Roma. The use of anthropometric parameters as rapid indicators of health status in screenings of a large number of subjects could be an effective and cheap method to provide preliminary indications on individuals or ethnic groups at greater risk of poor health.

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Heritability and genetic correlations of obesity-related phenotypes among Roma people

Cited by 12 publications

References 36 publications

Obesity and eating behavior from the perspective of twin and genetic research

Obesity and eating behavior from the perspective of twin and genetic research

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

Anthropometric parameters in relation to glycaemic status and lipid profile in a multi-ethnic sample in Italy

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