2020
DOI: 10.1038/s41598-020-71388-x
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Heritability estimates of the novel trait ‘suppressed in ovo virus infection’ in honey bees (Apis mellifera)

Abstract: Honey bees are under pressure due to abnormal high colony death rates, especially during the winter. the infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally considered as the bees' most important biological threats. Almost all efforts to remedy this dual infection have so far focused on the control of the Varroa mite alone and not on the viruses it transmits. In the present study, the sanitary control of breeding queens was conducted on eggs taken from drone… Show more

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Cited by 19 publications
(48 citation statements)
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“…In the absence of significant effects of resident viruses and other confounding factors, our IAPV-inoculated worker survival differences among and within stocks can be interpreted as genetic differences in IAPV susceptibility, which has also been reported in the egg stage [ 25 ]. We chose 3–5 day-old workers to conduct our experiments in workers with a fully-developed immune system because newly-emerged individuals have been shown to be particularly susceptible to disease [ 72 ].…”
Section: Discussionmentioning
confidence: 68%
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“…In the absence of significant effects of resident viruses and other confounding factors, our IAPV-inoculated worker survival differences among and within stocks can be interpreted as genetic differences in IAPV susceptibility, which has also been reported in the egg stage [ 25 ]. We chose 3–5 day-old workers to conduct our experiments in workers with a fully-developed immune system because newly-emerged individuals have been shown to be particularly susceptible to disease [ 72 ].…”
Section: Discussionmentioning
confidence: 68%
“…However, it also can cause sublethal infections [ 21 , 22 ] and persists asymptomatically at low quantities in honey populations, although it is far from ubiquitous [ 18 , 19 ]. Even though RNA interference (RNAi)-based vaccines against IAPV and other viruses are under development [ 23 , 24 ], selectively improving the existing honey bee immune defenses presents a practical and sustainable solution for improving honey bee health [ 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…This trait is described by the absence of virus infections in 10 pooled drone eggs and was the first study to show that the potential of honey bees to suppress virus infections is heritable (R ≈ 0.25). In addition, colonies headed by a SOV-positive queen have fewer and less severe DWV infections in almost all developmental phases of both worker bees and drones [27] indicating the beneficial implications for the health status of the colony. The underlying mechanisms of the SOV trait are yet to be discovered; possible hypotheses could be an increase in the expression [30] or effectivity [17] of the RNA interference pathway, transgenerational effects [31] or increased expression levels of Toll-6 which has been linked with survival after artificial infection with Israeli acute paralysis virus (IAPV) [32].…”
Section: Introductionmentioning
confidence: 99%
“…As the sole responsible for egg laying, honey bee queens play an important role in vertical transmission. This is reflected by the high presence of DWV encountered in the reproductive tissues, ovaries, spermatheca, and eggs, [23][24][25][26][27] which may be an adaptation to enhance vertical transmission [22]. Transmission from the queen's ovaries to her eggs occurs predominantly by virus particles adhering to the surface of the eggs (transovum) [22].…”
Section: Introductionmentioning
confidence: 99%
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