Heritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12

Rietveld, M.J.H.; Hudziak, James J.; Bartels, Meike; Beijsterveldt, Catharina E. M. van; Boomsma, Dorret I.

doi:10.1111/j.1469-7610.2004.00247.x

Cited by 199 publications

(161 citation statements)

References 73 publications

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“…The relevance of genetic influences across age groups was previously reported for attention problems and hyperactivity [45] and for aggressive behaviours [25,53].…”

Section: Discussionmentioning

confidence: 92%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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To cite this version:Chiara A. M. Spatola, Richard Rende, Marco Battaglia. Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges. European child & adolescent psychiatry, 2010, 19 (8), pp.647-658. <10.1007/s00787-010-0102-z>. ORIGINAL CONTRIBUTIONGenetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges Abstract Inasmuch as the newly established DSM-oriented CBCL/6-18 scales are to be increasingly employed to assess clinical/high-risk populations, it becomes important to explore their aetiology both within the normal-and the extreme range of variation in general population samples and to compare the results obtained in different age groups. We investigated by the Quantitative Maximum Likelihood, the De Fries-Fulker, and the Ordinal Maximum Likelihood methods the genetic and environmental influences upon the five DSM-oriented CBCL/6-18 scales in 796 twins aged 8-17 years belonging to the general population-based Italian Twin Registry. When children were analysed together regardless of age, most best-fitting solutions yielded genetic and non-shared environmental factors as the sole influences for DSMoriented CBCL/6-18 behaviours, both for the normal and the extreme variations. When analyses were conducted separately for two age groups, shared environmental influences emerged consistently for Affective and Anxiety Problems in children aged 8-11. Oppositional-Defiant, Attention Deficit/Hyperactivity, and Conduct Problems appeared-with few exceptions-influenced only by genetic and non-shared environmental factors in both age groups, according to all three computational approaches. The De Fries-Fulker method appeared to be more sensitive in detecting shared environmental effects. Analysing the same set of data with different analytic approaches leads to better-balanced views on the aetiology of psychopathological behaviours in the developmental years.

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“…The relevance of genetic influences across age groups was previously reported for attention problems and hyperactivity [45] and for aggressive behaviours [25,53].…”

Section: Discussionmentioning

confidence: 92%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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“…If these contrast effects are not accounted for in the analysis, mother ratings will result in lower DZ concordance rates and successively in an overestimation of heritability. Rater contrast effects were described for the Rutter-A scale, the DBRS, parental interview data obtained by the CAPA (Table 1) and for the CBCL at age 3 only but not for children aged 7-12 years old [47,89,90].…”

Section: Rater Effectsmentioning

confidence: 99%

“…A third twin study assessed stability and change of CBCL-derived attention problems (AP) from age 3 to 12 years [90]. Correlation of age 3 measures with age 7,10, and 12 year old measures was between 35 and 40%; correlation of age 7 measures with age 10 and age 12 year measures was between 67 and 75%.…”

Section: Longitudinal Coursementioning

confidence: 99%

Phenotypic and measurement influences on heritability estimates in childhood ADHD

Freitag

Rohde

Lempp

et al. 2010

Eur Child Adolesc Psychiatry

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Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature review reports findings from population-based twin studies regarding the influence of subtypes, assessment instruments, rater effects, sex differences, and comorbidity rates on ADHD heritability estimates. In addition, genetic effects on the persistence of ADHD are discussed. By reviewing relevant factors influencing heritability estimates more homogeneous subtypes relevant for molecular genetic studies can be elicited. A systematic search of population-based twin studies in ADHD was performed, using the databases PubMed and PsycInfo. Results of family studies were added in case insufficient or contradictory findings were obtained in twin studies. Heritability estimates were strongly influenced by rater effects and assessment instruments. Inattentive and hyperactiveimpulsive symptoms were likely influenced by common as well as specific genetic risk factors. Besides persistent ADHD, ADHD accompanied by symptoms of conduct or antisocial personality disorder might be another strongly genetically determined subtype, however, family environmental risk factors have also been established for this pattern of comorbidity.

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“…Here, twin studies have all shown that it is genetic factors that mainly account for continuity of ADHD symptoms over time. 28,[68][69][70] However, there is some additional genetic contribution specific to symptoms at the later time point in longitudinal studies. 28,68 This suggests that susceptibility genes for ADHD may also influence its continuity over time but that there may be additional genetic modifier loci that specifically influence the presence of symptoms at later ages.…”

Section: Persistence and Continuitymentioning

confidence: 99%

Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies

et al. 2006

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It is well established that attention deficit hyperactivity disorder (ADHD) is a familial and highly heritable disorder. Consequently, much effort is being directed towards searching for specific susceptibility genes. There is a growing trend, across the field of complex disease genetics, towards undertaking secondary analyses based on refined phenotypic definitions and in testing whether specific susceptibility genes modify the phenotypic presentation of the disorder in question. It is crucial that good, empirically derived arguments are made before undertaking multiple analyses on different phenotype refinements. In this review article, we consider the evidence from genetic epidemiological studies as well as key clinical studies that provide guidance on examining the ADHD phenotype for the purpose of molecular genetic studies. Specifically, findings on categorical versus dimensional conceptualisations of ADHD, reporter effects, comorbidity, ADHD subtypes and persistence are reviewed. Current evidence suggests that for the purpose of identifying susceptibility genes for ADHD, parent and teachers should be used as informants and that focusing on the clinical diagnosis of ADHD is useful. There is also good empirical support in favour of examining antisocial behaviour in ADHD. Genetic studies of dimensional ADHD are useful for other complementary purposes.

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Heritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12

Cited by 199 publications

References 73 publications

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Phenotypic and measurement influences on heritability estimates in childhood ADHD

Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies

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