2008
DOI: 10.1111/j.1365-2265.2008.03173.x
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Heritability of blood concentrations of sex‐steroids in relation to body composition in young adult male siblings

Abstract: Both sex steroid serum levels and body composition are under strong genetic control. Their interrelation is in part underlied by a genetic correlation, indicative of the action of shared genes.

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Cited by 45 publications
(54 citation statements)
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References 44 publications
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“…(GGT) 3 GGG(GGT)) 3 (GGC) n ; (GGT) 3 GGG(GGT) 4 (GGC) 16 ; (GGT) 3 GGG(GGT) 2 GGG(GGT) 2 (GGC) 18 and (GGT) 3 GGG(GGT) 2 GGC(GGT) 2 (GGC) 18 .…”
Section: Population Characteristicsunclassified
See 1 more Smart Citation
“…(GGT) 3 GGG(GGT)) 3 (GGC) n ; (GGT) 3 GGG(GGT) 4 (GGC) 16 ; (GGT) 3 GGG(GGT) 2 GGG(GGT) 2 (GGC) 18 and (GGT) 3 GGG(GGT) 2 GGC(GGT) 2 (GGC) 18 .…”
Section: Population Characteristicsunclassified
“…Young men (24-45 years) were included from the Siblos study (4,18), a population-based observational study designed to investigate genetic contribution to the determination of sex steroid levels and bone mass using a sib-pair design. For this study, we included a group of 358 unrelated men, i.e.…”
Section: Study Populationmentioning
confidence: 99%
“…4,53 These genetic findings in CYP19A1 , together with the aforementioned higher estrogen levels and aromatase activity in Black men, demonstrate that genetic variations in aromatase are major determinants of serum E2 levels and suggest that these variations indirectly might influence male bone health via altered E2 activity. Serum T. Studies in male twins indicate that there is a strong heritability of serum T. 66 However, the genetic determinants of serum T and the genetic risk factors for low concentrations are poorly understood. In an international consortium, we therefore recently performed a large-scale meta-analysis of genome-wide association studies to examine the effects of common genetic variants on serum T concentrations.…”
Section: Bmi-dependent Elevation In Asian Men Living In Asia Lower Lementioning
confidence: 99%
“…Although testosterone is the major precursor of estradiol in men (21), the ultimate concentrations of the latter are largely dependent on interindividual variation in several endogenous [enzymatic activity of aromatase (18) and estrogen degrading catechol-Omethyltransferase (17)] as well as exogenous factors. Consistently, estimates of phenotypic correlation between estradiol and testosterone differ across studies (22). In addition, the biological actions exerted by testosterone and estradiol on cardiovascular system are mediated by different types of receptors (23).…”
Section: Discussionmentioning
confidence: 89%
“…Indeed, a number of genetic and environmental determinants contribute to the overall phenotypic variation in cholesterol levels (24) and sex hormones (22) and the majority of the effects exerted by each individual factor is modest. Nevertheless, the demonstrated associations are likely to have a clinical significance.…”
Section: Discussionmentioning
confidence: 99%